STRINGSTRING
dcd dcd rbcL rbcL cmk cmk AFK50733.1 AFK50733.1 AFK50732.1 AFK50732.1 AFK50688.1 AFK50688.1 AFK50687.1 AFK50687.1 AFK50661.1 AFK50661.1 AFK50657.1 AFK50657.1 AFK50643.1 AFK50643.1 AFK50600.1 AFK50600.1 AFK50560.1 AFK50560.1 pyrG pyrG tmk tmk AFK50495.1 AFK50495.1 eno eno nadE nadE AFK51556.1 AFK51556.1 AFK51829.1 AFK51829.1 AFK51828.1 AFK51828.1 gap gap pgk pgk AFK51795.1 AFK51795.1 mvk mvk AFK51773.1 AFK51773.1 AFK51769.1 AFK51769.1 AFK51752.1 AFK51752.1 AFK51670.1 AFK51670.1 upp upp AFK51658.1 AFK51658.1 AFK51657.1 AFK51657.1 AFK51654.1 AFK51654.1 AFK51653.1 AFK51653.1 AFK51637.1 AFK51637.1 AFK51554.1 AFK51554.1 atpA atpA atpB atpB AFK51551.1 AFK51551.1 AFK51542.1 AFK51542.1 AFK51540.1 AFK51540.1 AFK51539.1 AFK51539.1 AFK51532.1 AFK51532.1 AFK51531.1 AFK51531.1 AFK51530.1 AFK51530.1 panB panB AFK51528.1 AFK51528.1 AFK51499.1 AFK51499.1 pyrE pyrE AFK51492.1 AFK51492.1 pyrB pyrB AFK51488.1 AFK51488.1 AFK51474.1 AFK51474.1 AFK51462.1 AFK51462.1 AFK51461.1 AFK51461.1 rbsK rbsK AFK51404.1 AFK51404.1 AFK51374.1 AFK51374.1 pyrD pyrD deoC deoC AFK51305.1 AFK51305.1 AFK51239.1 AFK51239.1 AFK51226.1 AFK51226.1 AFK51221.1 AFK51221.1 prs prs AFK51192.1 AFK51192.1 AFK51191.1 AFK51191.1 AFK51145.1 AFK51145.1 AFK51144.1 AFK51144.1 AFK51140.1 AFK51140.1 nnrE nnrE adk adk AFK51088.1 AFK51088.1 AFK51025.1 AFK51025.1 AFK51019.1 AFK51019.1 AFK50993.1 AFK50993.1 AFK50980.1 AFK50980.1 AFK50975.1 AFK50975.1 ndk ndk AFK50936.1 AFK50936.1 AFK50922.1 AFK50922.1 AFK50911.1 AFK50911.1 thyX thyX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (175 aa)
rbcLRibulose bisophosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (444 aa)
cmkCytidylate kinase. (187 aa)
AFK50733.1Pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit delta. (91 aa)
AFK50732.1Pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma. (190 aa)
AFK50688.1Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (203 aa)
AFK50687.1Pyruvate kinase; Belongs to the pyruvate kinase family. (473 aa)
AFK50661.1Adenine phosphoribosyltransferase. (288 aa)
AFK50657.1Histidine triad (HIT) protein. (159 aa)
AFK50643.1Nicotinamide-nucleotide adenylyltransferase. (175 aa)
AFK50600.1Thymidylate kinase-like protein. (202 aa)
AFK50560.1Phosphoribosyltransferase. (174 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (532 aa)
tmkThymidylate kinase. (205 aa)
AFK50495.1Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (286 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (441 aa)
nadENAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (281 aa)
AFK51556.1V-type ATP synthase subunit E. (197 aa)
AFK51829.1Fructose-1,6-bisphosphate aldolase. (270 aa)
AFK51828.1ATP-dependent phosphofructokinase; Belongs to the carbohydrate kinase PfkB family. (309 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase. (340 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (415 aa)
AFK51795.1Dihydroorotate dehydrogenase family protein. (408 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (321 aa)
AFK51773.1hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (428 aa)
AFK51769.1Phosphoribosyltransferase. (215 aa)
AFK51752.1Cytidyltransferase-related domain protein. (175 aa)
AFK51670.1AMP phosphorylase / thymidine phosphorylase. (509 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (222 aa)
AFK51658.1Pyruvate ferredoxinoxidoreductase subunit delta. (90 aa)
AFK51657.1Pyruvate ferredoxinoxidoreductase subunit gamma. (186 aa)
AFK51654.12-oxoglutarate ferredoxin oxidoreductase subunit beta. (275 aa)
AFK51653.12-oxoglutarate ferredoxin oxidoreductase subunit gamma. (179 aa)
AFK51637.1Metal-dependent phosphohydrolase, HD region. (496 aa)
AFK51554.1V-type ATP synthase subunit F. (102 aa)
atpAV-type ATP synthase subunit A; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. Belongs to the ATPase alpha/beta chains family. (591 aa)
atpBV-type ATP synthase subunit B; Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. (462 aa)
AFK51551.1V-type ATP synthase subunit D. (211 aa)
AFK51542.1Ferredoxin:NADP oxidoreductase, small subunit. (269 aa)
AFK51540.1NTPase; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (181 aa)
AFK51539.1Indolepyruvate ferredoxin oxidoreductase subunit beta. (203 aa)
AFK51532.1DUF137 domain containing protein. (232 aa)
AFK51531.1Kinase (sugar kinase superfamily)-like protein. (302 aa)
AFK51530.1Phosphoglycerate mutase. (426 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa)
AFK51528.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (315 aa)
AFK51499.1Putative allantoinase. (444 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (197 aa)
AFK51492.1Orotidine-5'-phosphate decarboxylase. (224 aa)
pyrBAspartate carbamoyltransferase. (310 aa)
AFK51488.1Putative molybdenum utilization protein ModD; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (282 aa)
AFK51474.1[NiFe] hydrogenase, gamma subunit. (275 aa)
AFK51462.1Bifunctional GMP synthase/glutamine amidotransferase protein. (600 aa)
AFK51461.1Phosphoribosyltransferase. (215 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (314 aa)
AFK51404.1Hypothetical protein. (254 aa)
AFK51374.1Dihydroorotate dehydrogenase, electron transfer subunit. (247 aa)
pyrDDihydroorotate dehydrogenase, catalytic subunit; Catalyzes the conversion of dihydroorotate to orotate. (306 aa)
deoCDeoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (239 aa)
AFK51305.1Amidohydrolase. (449 aa)
AFK51239.1Metal dependent phosphohydrolase. (537 aa)
AFK51226.1ATP-NAD/AcoX kinase. (370 aa)
AFK51221.1Phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase. (404 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (298 aa)
AFK51192.1Molybdopterin binding domain protein. (246 aa)
AFK51191.1Nicotinamide-nucleotide adenylyltransferase (NAD(+) pyrophosphorylase) (NAD(+) diphosphorylase) (NMN adenylyltransferase). (176 aa)
AFK51145.1PfkB domain protein. (325 aa)
AFK51144.1Uridine phosphorylase. (276 aa)
AFK51140.1Nicotinate phosphoribosyltransferase. (391 aa)
nnrECarbohydrate kinase, YjeF related protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow t [...] (535 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (219 aa)
AFK51088.1Indolepyruvate ferredoxin oxidoreductase subunit beta; Energy production and conversion; pfam01558, POR, Pyruvate ferredoxin/flavodoxin oxidoreductase. (209 aa)
AFK51025.1Putative transcription regulator, containing Crp and DUF120 domains; Pfam01982, DUF120, Domain of unknown function DUF120. (124 aa)
AFK51019.1Putative adenylyl cyclase CyaB. (177 aa)
AFK50993.1ATP-NAD/AcoX kinase. (269 aa)
AFK50980.1Non-canonical purine NTP pyrophosphatase, rdgB/HAM1 family. (193 aa)
AFK50975.1Hypothetical protein; Catalyzes the GTP-dependent phosphorylation of the 3'- hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). (158 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (143 aa)
AFK50936.1Nucleotide kinase-like protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (198 aa)
AFK50922.1Uridylate kinase, putative; Catalyzes the reversible phosphorylation of UMP to UDP. (223 aa)
AFK50911.1Phosphoribosyltransferase. (223 aa)
thyXThymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. (305 aa)
Your Current Organism:
Thermogladius calderae
NCBI taxonomy Id: 1184251
Other names: T. calderae 1633, Thermogladius calderae 1633
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