STRINGSTRING
mat mat AFK50449.1 AFK50449.1 AFK50455.1 AFK50455.1 eno eno AFK50495.1 AFK50495.1 rpiA rpiA AFK50525.1 AFK50525.1 AFK50529.1 AFK50529.1 AFK50538.1 AFK50538.1 ubiX ubiX AFK50596.1 AFK50596.1 AFK50602.1 AFK50602.1 AFK50603.1 AFK50603.1 AFK50604.1 AFK50604.1 AFK50605.1 AFK50605.1 AFK50630.1 AFK50630.1 AFK50687.1 AFK50687.1 AFK50688.1 AFK50688.1 fbp fbp AFK50732.1 AFK50732.1 AFK50733.1 AFK50733.1 AFK50735.1 AFK50735.1 AFK50785.1 AFK50785.1 rbcL rbcL AFK50826.1 AFK50826.1 AFK50889.1 AFK50889.1 AFK50894.1 AFK50894.1 AFK50924.1 AFK50924.1 AFK50936.1 AFK50936.1 fni fni gltX gltX ndk ndk AFK50983.1 AFK50983.1 AFK51076.1 AFK51076.1 AFK51094.1 AFK51094.1 adk adk AFK51115.1 AFK51115.1 sucC sucC sucD sucD AFK51165.1 AFK51165.1 AFK51176.1 AFK51176.1 AFK51198.1 AFK51198.1 leuC leuC leuD leuD AFK51201.1 AFK51201.1 AFK51202.1 AFK51202.1 AFK51203.1 AFK51203.1 AFK51204.1 AFK51204.1 AFK51205.1 AFK51205.1 AFK51206.1 AFK51206.1 thrB thrB prs prs AFK51223.1 AFK51223.1 gcvH gcvH glyA glyA AFK51227.1 AFK51227.1 gcvPA gcvPA AFK51229.1 AFK51229.1 AFK51230.1 AFK51230.1 AFK51266.1 AFK51266.1 AFK51271.1 AFK51271.1 AFK51279.1 AFK51279.1 AFK51296.1 AFK51296.1 AFK51323.1 AFK51323.1 AFK51337.1 AFK51337.1 AFK51356.1 AFK51356.1 AFK51357.1 AFK51357.1 AFK51358.1 AFK51358.1 AFK51366.1 AFK51366.1 AFK51367.1 AFK51367.1 AFK51414.1 AFK51414.1 hisD hisD AFK51500.1 AFK51500.1 pckG pckG AFK51519.1 AFK51519.1 AFK51520.1 AFK51520.1 AFK51521.1 AFK51521.1 AFK51528.1 AFK51528.1 panB panB AFK51530.1 AFK51530.1 AFK51541.1 AFK51541.1 AFK51580.1 AFK51580.1 AFK51583.1 AFK51583.1 proC proC AFK51653.1 AFK51653.1 AFK51654.1 AFK51654.1 AFK51655.1 AFK51655.1 AFK51656.1 AFK51656.1 AFK51657.1 AFK51657.1 AFK51658.1 AFK51658.1 AFK51659.1 AFK51659.1 AFK51660.1 AFK51660.1 trpB trpB AFK51708.1 AFK51708.1 AFK51729.1 AFK51729.1 AFK51735.1 AFK51735.1 AFK51764.1 AFK51764.1 AFK51773.1 AFK51773.1 mvk mvk argF argF pgk pgk gap gap AFK51800.1 AFK51800.1 AFK51829.1 AFK51829.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
matMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP; Belongs to the AdoMet synthase 2 family. (413 aa)
AFK50449.1Pyridoxal-dependent decarboxylase. (384 aa)
AFK50455.1Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; Belongs to the phosphohexose mutase family. (458 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (441 aa)
AFK50495.1Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family. (286 aa)
rpiARibose 5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (243 aa)
AFK50525.1D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding protein. (309 aa)
AFK50529.1Fructose-1,6-bisphosphatase. (260 aa)
AFK50538.1Sugar-phosphate isomerase, RpiB/LacA/LacB family. (155 aa)
ubiX3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (201 aa)
AFK50596.1Cysteine synthase. (394 aa)
AFK50602.1dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (186 aa)
AFK50603.1dTDP-4-dehydrorhamnose reductase. (298 aa)
AFK50604.1dTDP-glucose 4,6-dehydratase. (333 aa)
AFK50605.1Glucose-1-phosphate thymidylyltransferase. (354 aa)
AFK50630.1Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (360 aa)
AFK50687.1Pyruvate kinase; Belongs to the pyruvate kinase family. (473 aa)
AFK50688.1Triosephosphate isomerase; Belongs to the triosephosphate isomerase family. (203 aa)
fbpFructose-1,6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (384 aa)
AFK50732.1Pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma. (190 aa)
AFK50733.1Pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit delta. (91 aa)
AFK50735.1Pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit beta. (297 aa)
AFK50785.1Nucleotidyl transferase. (258 aa)
rbcLRibulose bisophosphate carboxylase; Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase. Belongs to the RuBisCO large chain family. Type III subfamily. (444 aa)
AFK50826.1Nucleotidyl transferase. (424 aa)
AFK50889.1SPP-like hydrolase; Catalyzes the dephosphorylation of 2-phosphoglycolate. (242 aa)
AFK50894.1Glucose-6-phosphate isomerase; Carbohydrate transport and metabolism. (332 aa)
AFK50924.1Nucleotidyl transferase. (394 aa)
AFK50936.1Nucleotide kinase-like protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (198 aa)
fniIsopentenyl-diphosphate delta-isomerase, type 2; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (355 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (579 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. (143 aa)
AFK50983.1Pullulanase. (673 aa)
AFK51076.1Pyridoxal-5'-phosphate-dependent enzyme, beta subunit. (335 aa)
AFK51094.1Myo-inositol-1-phosphate synthase. (381 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (219 aa)
AFK51115.1Methionine synthase II (cobalamin-independent)-like protein. (317 aa)
sucCsuccinyl-CoA synthetase, beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (377 aa)
sucDsuccinyl-CoA synthetase, alpha subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (265 aa)
AFK51165.1Polyprenyl synthetase; Belongs to the FPP/GGPP synthase family. (359 aa)
AFK51176.1Aspartate/glutamate/uridylate kinase. (259 aa)
AFK51198.1Pyruvate carboxyltransferase. (427 aa)
leuC3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (404 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (171 aa)
AFK51201.1Isocitrate dehydrogenase. (341 aa)
AFK51202.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (346 aa)
AFK51203.1Cystathionine gamma-synthase. (386 aa)
AFK51204.1Aspartate-semialdehyde dehydrogenase. (354 aa)
AFK51205.1Aspartate kinase. (372 aa)
AFK51206.1Homoserine dehydrogenase. (339 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (314 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P). (298 aa)
AFK51223.1Aminotransferase. (405 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (146 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (437 aa)
AFK51227.1Glycine cleavage system aminomethyltransferase T. (371 aa)
gcvPAGlycine dehydrogenase subunit alpha; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (455 aa)
AFK51229.1Glycine dehydrogenase subunit beta. (519 aa)
AFK51230.1Dihydrolipoamide dehydrogenase. (456 aa)
AFK51266.1Nucleotidyl transferase. (836 aa)
AFK51271.1Glycerol-3-phosphate cytidylyltransferase. (234 aa)
AFK51279.1Hexokinase; Galactose metabolism Glycolysis / Gluconeogenesis Starch and sucrose metabolism Streptomycin biosynthesis; pfam00480, ROK, ROK family. (318 aa)
AFK51296.1Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (425 aa)
AFK51323.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (838 aa)
AFK51337.1Peptidase T2, asparaginase 2. (318 aa)
AFK51356.1Biotin/lipoyl attachment domain-containing protein. (171 aa)
AFK51357.1Carboxyl transferase. (520 aa)
AFK51358.1Thiolase. (391 aa)
AFK51366.1Nucleotidyl transferase. (373 aa)
AFK51367.1Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I. (409 aa)
AFK51414.1Sulfide dehydrogenase subunit SudA. (367 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa)
AFK51500.1Aminotransferase, class I and II. (399 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle. (633 aa)
AFK51519.1Glycosyl transferase, group 1. (520 aa)
AFK51520.1Glycoside hydrolase, family 57. (640 aa)
AFK51521.1Glycoside hydrolase, family 57. (513 aa)
AFK51528.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (315 aa)
panB3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (273 aa)
AFK51530.1Phosphoglycerate mutase. (426 aa)
AFK51541.1Ferredoxin:NADP oxidoreductase, large subunit. (470 aa)
AFK51580.1Putative transcriptional regulator, GntR family. (404 aa)
AFK51583.1hydroxymethylglutaryl-CoA synthase; Belongs to the thiolase-like superfamily. UPF0219 family. (352 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa)
AFK51653.12-oxoglutarate ferredoxin oxidoreductase subunit gamma. (179 aa)
AFK51654.12-oxoglutarate ferredoxin oxidoreductase subunit beta. (275 aa)
AFK51655.12-oxoglutarate ferredoxin oxidoreductase subunit alpha. (374 aa)
AFK51656.12-oxoglutarate ferredoxin oxidoreductase subunit delta. (83 aa)
AFK51657.1Pyruvate ferredoxinoxidoreductase subunit gamma. (186 aa)
AFK51658.1Pyruvate ferredoxinoxidoreductase subunit delta. (90 aa)
AFK51659.1Pyruvate ferredoxinoxidoreductase subunit alpha. (422 aa)
AFK51660.1Pyruvate ferredoxin oxidoreductase subunit beta. (355 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (437 aa)
AFK51708.1Alpha amylase. (693 aa)
AFK51729.1Phosphatases-like protein. (231 aa)
AFK51735.1Phosphoserine phosphatase. (221 aa)
AFK51764.1Threonine synthase. (433 aa)
AFK51773.1hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (428 aa)
mvkMevalonate kinase; Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)- mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (321 aa)
argFOrnithine carbamoyltransferase. (314 aa)
pgkPhosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (415 aa)
gapGlyceraldehyde-3-phosphate dehydrogenase. (340 aa)
AFK51800.1Glycosyl transferase, group 1. (507 aa)
AFK51829.1Fructose-1,6-bisphosphate aldolase. (270 aa)
Your Current Organism:
Thermogladius calderae
NCBI taxonomy Id: 1184251
Other names: T. calderae 1633, Thermogladius calderae 1633
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