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| | glmU | UDP-N-acetylglucosamine pyrophosphorylase / diamine N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (458 aa) |
| | A11Q_2176 | Acyltransferase; COG0204I. (288 aa) |
| | A11Q_2263 | Flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (419 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (271 aa) |
| | A11Q_2331 | Phosphatase; COG0671I. (190 aa) |
| | A11Q_2365 | Hypothetical protein; COG0634F; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (172 aa) |
| | ndk | Hypothetical protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (545 aa) |
| | rsfS | Nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). Belongs to the Iojap/RsfS family. (347 aa) |
| | atpC | ATP synthase epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (134 aa) |
| | atpD | F0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (468 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa) |
| | atpA | F0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (506 aa) |
| | atpH | ATP synthase, delta (OSCP) subunit, ATP synthase, delta (OSCP) subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (180 aa) |
| | A11Q_1810 | Hypothetical protein; COG0204I. (256 aa) |
| | A11Q_1827 | Hypothetical protein; COG0157H; Belongs to the NadC/ModD family. (274 aa) |
| | A11Q_1846 | Acyltransferase family protein; COG0204I. (266 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa) |
| | A11Q_1925 | Hypothetical protein. (173 aa) |
| | A11Q_1928 | Orotidine 5'-phosphate decarboxylase; COG0284F. (234 aa) |
| | A11Q_1978 | L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (523 aa) |
| | A11Q_198 | Quinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (325 aa) |
| | coaE | Hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa) |
| | nadK | Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (298 aa) |
| | A11Q_2006 | UDP-2,3-diacylglucosamine hydrolase; COG2908S. (249 aa) |
| | A11Q_2034 | Hypoxanthine-guanine phosphoribosyltransferase-like protein; COG0634F; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (178 aa) |
| | A11Q_683 | Hypothetical protein. (373 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (168 aa) |
| | A11Q_745 | Aspartate carbamoyltransferase; COG0540F; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (312 aa) |
| | carA | Carbamoyl phosphate synthase small subunit; COG0505EF; Belongs to the CarA family. (373 aa) |
| | A11Q_748 | Carbamoyl-phosphate synthase; COG0458EF; Belongs to the CarB family. (1058 aa) |
| | A11Q_758 | Hypothetical protein; COG0662G. (100 aa) |
| | A11Q_782 | UDP glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (333 aa) |
| | A11Q_794 | 3-methyl-2-oxobutanoate dehydrogenase; COG1071C. (346 aa) |
| | A11Q_800 | Hypothetical protein. (376 aa) |
| | pyrE | Hypothetical protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (173 aa) |
| | tmk | Hypothetical protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (211 aa) |
| | cmk | Hypothetical protein; COG0283F. (217 aa) |
| | A11Q_896 | Hypothetical protein. (611 aa) |
| | atpB | ATP synthase F0, A subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (228 aa) |
| | A11Q_918 | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (269 aa) |
| | A11Q_920 | Lipid A disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (383 aa) |
| | lpxK | Tetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (325 aa) |
| | A11Q_927 | Riboflavin kinase / FAD synthase ribC; COG0196H; Belongs to the ribF family. (311 aa) |
| | pdxH | Pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (196 aa) |
| | A11Q_943 | Hypothetical protein. (464 aa) |
| | folE | GTP cyclohydrolase I; COG0302H. (227 aa) |
| | lpxC | UDP-3-O-acyl-N-acetylglucosamine deacetylase lpxC; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (300 aa) |
| | A11Q_990 | Phenol 2-monooxygenase; COG0543HC. (241 aa) |
| | A11Q_997 | Deoxycytidine triphosphate deaminase; COG0717F. (178 aa) |
| | atpF | ATP synthase B chain; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (187 aa) |
| | A11Q_2611 | ATP synthase B chain; COG0711C; Belongs to the ATPase B chain family. (145 aa) |
| | A11Q_263 | Hypothetical protein. (197 aa) |
| | A11Q_341 | Hypothetical protein. (406 aa) |
| | A11Q_355 | Hypothetical protein. (443 aa) |
| | A11Q_515 | Hypothetical protein. (410 aa) |
| | A11Q_542 | Hypothetical protein; COG1183I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (276 aa) |
| | A11Q_554 | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (164 aa) |
| | A11Q_555 | CinA-like protein; COG1546R; Belongs to the CinA family. (177 aa) |
| | A11Q_573 | Hypothetical protein. (228 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (278 aa) |
| | A11Q_674 | Dihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (339 aa) |
| | A11Q_1791 | Hypothetical protein. (218 aa) |
| | A11Q_1749 | Hypothetical protein; COG0035F; Belongs to the UPRTase family. (210 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa) |
| | A11Q_1748 | Uridine kinase; COG0572F; Belongs to the uridine kinase family. (217 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa) |
| | A11Q_1690 | Nucleotide-utilizing enzyme; COG1058R. (377 aa) |
| | A11Q_1634 | Acetyl coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (646 aa) |
| | purK | Hypothetical protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (373 aa) |
| | dut | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (147 aa) |
| | gmk | Hypothetical protein; Essential for recycling GMP and indirectly, cGMP. (185 aa) |
| | A11Q_1498 | Diphosphomevalonate decarboxylase; COG3407I. (326 aa) |
| | A11Q_1496 | Hypothetical protein. (230 aa) |
| | A11Q_1470 | Hypothetical protein. (308 aa) |
| | A11Q_1381 | Hypothetical protein; COG0558I; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (180 aa) |
| | dacA | Hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria. (271 aa) |
| | A11Q_1356 | Hypothetical protein; COG0015F; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (429 aa) |
| | pyrH | Hypothetical protein; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa) |
| | A11Q_1334 | Ribonucleotide-diphosphate reductase small chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (332 aa) |
| | A11Q_131 | Phosphatidate cytidylyltransferase; COG0575I. (270 aa) |
| | guaA | Bifunctional GMP synthase/glutamine amidotransferase protein; Catalyzes the synthesis of GMP from XMP. (515 aa) |
| | guaB | Inosine-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (495 aa) |
| | A11Q_1245 | Hypothetical protein. (223 aa) |
| | A11Q_12 | Pyridoxal phosphate biosynthetic protein; COG1995H; Belongs to the PdxA family. (335 aa) |
| | A11Q_1190 | Hypothetical protein. (489 aa) |
| | A11Q_1151 | Hypothetical protein. (578 aa) |
| | A11Q_1101 | Phosphatidylserine decarboxylase proenzyme; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (274 aa) |
| | A11Q_1093 | Putative lysophosphatidic acid acyltransferase; COG0204I. (244 aa) |
| | A11Q_1090 | Adenylate cyclase; COG2114T. (801 aa) |
| | A11Q_1038 | Hypothetical protein. (257 aa) |
| | A11Q_1018 | Hypothetical protein. (476 aa) |
| | atpE | ATP synthase subunit C; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (111 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | coaD | Hypothetical protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (160 aa) |
| | A11Q_2143 | Flagellum-specific ATP synthase; COG1157NU. (439 aa) |
| | tdk | Thymidine kinase; COG1435F. (196 aa) |
