STRINGSTRING
A11Q_1021 A11Q_1021 A11Q_1082 A11Q_1082 A11Q_1084 A11Q_1084 A11Q_1095 A11Q_1095 A11Q_1096 A11Q_1096 A11Q_1230 A11Q_1230 A11Q_1271 A11Q_1271 A11Q_1274 A11Q_1274 A11Q_1325 A11Q_1325 glyA glyA A11Q_1453 A11Q_1453 fumC fumC A11Q_1634 A11Q_1634 A11Q_1653 A11Q_1653 A11Q_1710 A11Q_1710 A11Q_1752 A11Q_1752 A11Q_1773 A11Q_1773 prs prs gpmA gpmA A11Q_1815 A11Q_1815 A11Q_1816 A11Q_1816 A11Q_1817 A11Q_1817 A11Q_1822 A11Q_1822 A11Q_1833 A11Q_1833 A11Q_1843 A11Q_1843 A11Q_19 A11Q_19 A11Q_1968 A11Q_1968 A11Q_20 A11Q_20 A11Q_21 A11Q_21 A11Q_2102 A11Q_2102 pfkA pfkA A11Q_2216 A11Q_2216 A11Q_2327 A11Q_2327 A11Q_237 A11Q_237 mdh mdh sucC sucC sucD sucD A11Q_2561 A11Q_2561 A11Q_2562 A11Q_2562 A11Q_286 A11Q_286 A11Q_331 A11Q_331 A11Q_440 A11Q_440 A11Q_474 A11Q_474 A11Q_489 A11Q_489 tal tal folD folD gcvH gcvH gcvT gcvT gcvP gcvP A11Q_675 A11Q_675 A11Q_696 A11Q_696 A11Q_697 A11Q_697 eno eno A11Q_786 A11Q_786 A11Q_829 A11Q_829 pgk pgk tpiA tpiA A11Q_832 A11Q_832 A11Q_895 A11Q_895
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A11Q_1021Fructose-bisphosphate aldolase; COG1830G. (308 aa)
A11Q_1082NADP-dependent malate dehydrogenase; COG0281C. (774 aa)
A11Q_1084Fatty oxidation complex, alpha subunit; COG1250I; Belongs to the enoyl-CoA hydratase/isomerase family. (716 aa)
A11Q_10953-hydroxybutyryl-CoA dehydrogenase; COG1250I. (296 aa)
A11Q_1096Hypothetical protein; COG1024I; Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa)
A11Q_1230Hypothetical protein; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle. (785 aa)
A11Q_1271Hypothetical protein; COG0469G; Belongs to the pyruvate kinase family. (497 aa)
A11Q_1274acetyl-CoA acetyltransferase; COG0183I; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
A11Q_1325Ribose 5-phosphate isomerase B; COG0698G. (151 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (419 aa)
A11Q_1453Hypothetical protein; COG0031E. (335 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
A11Q_1634Acetyl coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. (646 aa)
A11Q_16533-isopropylmalate dehydrogenase; COG0473CE. (339 aa)
A11Q_1710Phosphoglycerate dehydrogenase; COG0111HE; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (327 aa)
A11Q_1752Methylmalonate-semialdehyde dehydrogenase; COG1012C. (491 aa)
A11Q_1773Hypothetical protein. (412 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa)
gpmAPhosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (249 aa)
A11Q_1815Alpha-ketoglutarate decarboxylase; COG0567C. (903 aa)
A11Q_18162-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (423 aa)
A11Q_1817Dihydrolipoamide dehydrogenase; COG1249C. (471 aa)
A11Q_1822Ribulose-phosphate 3-epimerase; COG0036G; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa)
A11Q_1833Aconitate hydratase; COG1048C. (752 aa)
A11Q_1843D-3-phosphoglycerate dehydrogenase; Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L- serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (402 aa)
A11Q_19Putative cytochrome B subunit. (220 aa)
A11Q_1968Hypothetical protein; COG1045E. (170 aa)
A11Q_20Succinate dehydrogenase flavoprotein subunit; COG1053C. (638 aa)
A11Q_21Succinate dehydrogenase/fumarate reductase iron-sulfur subunit; COG0479C. (263 aa)
A11Q_2102Hypothetical protein; COG0372C; Belongs to the citrate synthase family. (378 aa)
pfkAHypothetical protein; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (327 aa)
A11Q_2216Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (938 aa)
A11Q_2327Hypothetical protein; Belongs to the thiolase-like superfamily. Thiolase family. (426 aa)
A11Q_237Hypothetical protein. (510 aa)
mdhHypothetical protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (314 aa)
sucCsuccinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (387 aa)
sucDsuccinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (289 aa)
A11Q_2561propionyl-CoA carboxylase beta chain; COG4799I. (518 aa)
A11Q_2562Pyruvate carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (502 aa)
A11Q_286Hypothetical protein. (325 aa)
A11Q_331Hypothetical protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (894 aa)
A11Q_440Glycine cleavage system protein H-like protein; COG0509E. (145 aa)
A11Q_474Hypothetical protein; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (408 aa)
A11Q_489Hypothetical protein; COG0021G. (675 aa)
talPutative translaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (215 aa)
folDMethylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (278 aa)
gcvHGlycine cleavage system protein H-like protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
gcvTAminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. (364 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (951 aa)
A11Q_675Glutamate dehydrogenase; COG0334E; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (430 aa)
A11Q_696Dihydrolipoamide dehydrogenase, E3 subunit; COG1249C. (480 aa)
A11Q_697Pyruvate dehydrogenase E2; COG0508C. (550 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (422 aa)
A11Q_786Hypothetical protein; Belongs to the phosphoglycerate mutase family. (203 aa)
A11Q_829Glyceraldehyde-3-phosphate dehydrogenase; COG0057G; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (332 aa)
pgkPhosphoglycerate kinase; COG0126G; Belongs to the phosphoglycerate kinase family. (406 aa)
tpiAHypothetical protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
A11Q_832Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (400 aa)
A11Q_895Pyruvate phosphate dikinase; COG0574G; Belongs to the PEP-utilizing enzyme family. (888 aa)
Your Current Organism:
Bdellovibrio exovorus
NCBI taxonomy Id: 1184267
Other names: B. exovorus JSS, Bdellovibrio exovorus JSS, Bdellovibrio exovorus str. JSS, Bdellovibrio exovorus strain JSS, Bdellovibrio sp. JSS
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