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argB argB argD1 argD1 argF1 argF1 AFL48770.1 AFL48770.1 hisD hisD dadA1 dadA1 hisS hisS hisZ hisZ AFL49116.1 AFL49116.1 AFL49117.1 AFL49117.1 aroC aroC hisC1 hisC1 dapA1 dapA1 arcB1 arcB1 dadA3 dadA3 AFL50721.1 AFL50721.1 melA1 melA1 suhB1 suhB1 pheC pheC vllY vllY aroE1 aroE1 AFL50809.1 AFL50809.1 AFL50981.1 AFL50981.1 aatB1 aatB1 dapAf2 dapAf2 dapA3 dapA3 AFL51354.1 AFL51354.1 argE argE argC argC speB2 speB2 aroQ1 aroQ1 hisI hisI dat dat dapA4 dapA4 trpC trpC trpD trpD argF2 argF2 aroH aroH aatA aatA AFL53253.1 AFL53253.1 lysC lysC argJ argJ argH argH lysA lysA tyrC tyrC hisC2 hisC2 aroB aroB aroK aroK AFL53651.1 AFL53651.1 suhB2 suhB2 yjbG yjbG pabB pabB AFL53791.1 AFL53791.1 hisN hisN cyaB cyaB ldc ldc dadA5 dadA5 maiA maiA AFL53935.1 AFL53935.1 hmgA hmgA AFL53937.1 AFL53937.1 hpd hpd arcB3 arcB3 rocD rocD aroQ2 aroQ2 aroE2 aroE2 hisC3 hisC3 argG argG dapF dapF pheAa pheAa aatB2 aatB2 asd asd aroE3 aroE3 trpF trpF trpB trpB trpA trpA hisE hisE hisF hisF hisA hisA hisH hisH hisB hisB dapB dapB pheA pheA aroA aroA tatA2 tatA2 yhhY yhhY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
argBAcetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa)
argD1Acetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa)
argF1Ornithine carbamoyltransferase ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (305 aa)
AFL48770.1Hypothetical protein. (101 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa)
dadA1D-amino acid dehydrogenase small subunit DadA; Oxidative deamination of D-amino acids. (415 aa)
hisShistidine--tRNA ligase HisS. (507 aa)
hisZATP phosphoribosyltransferase regulatory subunit HisZ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (379 aa)
AFL49116.1Inositol monophosphatase family protein. (272 aa)
AFL49117.1Hypothetical protein. (78 aa)
aroCChorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa)
hisC1Histidinol-phosphate aminotransferase. (373 aa)
dapA1Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa)
arcB1Ornithine cyclodeaminase ArcB. (349 aa)
dadA3D-amino acid dehydrogenase small subunit DadA; Oxidative deamination of D-amino acids. (416 aa)
AFL50721.1Shikimate 5-dehydrogenase. (277 aa)
melA1Protein MelA. (629 aa)
suhB1Inositol-1-monophosphatase SuhB. (266 aa)
pheCCyclohexadienyl dehydratase PheC. (256 aa)
vllYHemolysin VllY. (629 aa)
aroE1Shikimate dehydrogenase AroE. (291 aa)
AFL50809.1Transcriptional regulator, TetR/ArcR family. (255 aa)
AFL50981.1Uncharacterized protein y4yA. (457 aa)
aatB1Aspartate aminotransferase B. (403 aa)
dapAf2Dihydrodipicolinate synthase protein; Belongs to the DapA family. (315 aa)
dapA3Dihydrodipicolinate synthase DapA; Belongs to the DapA family. (292 aa)
AFL51354.1Dihydrodipicolinate synthase; Belongs to the DapA family. (297 aa)
argEAcetylornithine deacetylase ArgE. (375 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa)
speB2Agmatinase SpeB; Belongs to the arginase family. (318 aa)
aroQ13-dehydroquinate dehydratase AroQ; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa)
hisIphosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (150 aa)
datD-alanine aminotransferase Dat. (287 aa)
dapA4Dihydrodipicolinate synthase DapA; Belongs to the DapA family. (296 aa)
trpCIndole-3-glycerol phosphate synthase TrpC; Belongs to the TrpC family. (271 aa)
trpDAnthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa)
argF2Ornithine carbamoyltransferase ArgF. (341 aa)
aroHPhospho-2-dehydro-3-deoxyheptonate aldolase AroH. (457 aa)
aatAAspartate aminotransferase A. (456 aa)
AFL53253.1trpE(G): anthranilate synthase. (729 aa)
lysCAspartokinase LysC; Belongs to the aspartokinase family. (424 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa)
argHArgininosuccinate lyase ArgH. (467 aa)
lysADiaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa)
tyrCProtein TyrC. (308 aa)
hisC2Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa)
aroB3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (376 aa)
aroKShikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (195 aa)
AFL53651.1Uncharacterized protein. (367 aa)
suhB2Inositol-1-monophosphatase SuhB. (266 aa)
yjbGOligoendopeptidase F. (673 aa)
pabBPara-aminobenzoate synthase component 1. (385 aa)
AFL53791.1Putative aminotransferase, class IV. (208 aa)
hisNHistidinol-phosphatase HisN. (258 aa)
cyaBAdenylate cyclase 2. (1086 aa)
ldcLysine/ornithine decarboxylase Ldc; Belongs to the Orn/Lys/Arg decarboxylase class-II family. (377 aa)
dadA5D-amino acid dehydrogenase small subunit DadA. (411 aa)
maiAMaleylacetoacetate isomerase MaiA. (213 aa)
AFL53935.1Fumarylacetoacetate hydrolase family protein. (338 aa)
hmgAHomogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (453 aa)
AFL53937.1Putative transcriptional regulator, MarR family. (149 aa)
hpd4-hydroxyphenylpyruvate dioxygenase Hpd. (372 aa)
arcB3Arginase ArcB; Belongs to the arginase family. (307 aa)
rocDOrnithine aminotransferase RocD; Catalyzes the interconversion of ornithine to glutamate semialdehyde. (401 aa)
aroQ23-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
aroE2Shikimate dehydrogenase AroE; Belongs to the shikimate dehydrogenase family. (286 aa)
hisC3Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa)
argGArgininosuccinate synthase ArgG; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa)
dapFDiaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (300 aa)
pheAaPutative chorismate mutase. (112 aa)
aatB2Aspartate aminotransferase B. (410 aa)
asdAspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
aroE3Shikimate dehydrogenase AroE; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase TrpF; Belongs to the TrpF family. (224 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa)
hisEphosphoribosyl-ATP pyrophosphatase HisE. (107 aa)
hisFImidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. (245 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa)
hisBImidazoleglycerol-phosphate dehydratase HisB. (202 aa)
dapBDihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (272 aa)
pheAP-protein PheA. (316 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (448 aa)
tatA2Tyrosine aminotransferase TatA. (389 aa)
yhhYPutative N-acetyltransferase YhhY. (167 aa)
Your Current Organism:
Sinorhizobium fredii USDA257
NCBI taxonomy Id: 1185652
Other names: S. fredii USDA 257, Sinorhizobium fredii USDA 257, Sinorhizobium fredii str. USDA 257, Sinorhizobium fredii strain USDA 257
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