STRINGSTRING
AFL50152.1 AFL50152.1 acoC1 acoC1 acoC2 acoC2 lpdA1 lpdA1 pdhC1 pdhC1 pdhA1 pdhA1 acnA1 acnA1 lpd3 lpd3 sucB1 sucB1 pdhA2 pdhA2 pdhB pdhB pdhC2 pdhC2 lpdA2 lpdA2 gltA gltA icd icd fumC fumC lpdV lpdV lpd lpd sucB2 sucB2 sucA sucA sucD sucD sucC sucC mdh2 mdh2 sdhB sdhB sdhA sdhA AFL54101.1 AFL54101.1 AFL54102.1 AFL54102.1 acnA2 acnA2 pyc pyc pckA pckA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AFL50152.1Putative citrate synthase; Belongs to the citrate synthase family. (263 aa)
acoC1Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system. (372 aa)
acoC2Dihydrolipoyllysine-residue acetyltransferase component of acetoin cleaving system. (375 aa)
lpdA1Dihydrolipoyl dehydrogenase LpdA. (479 aa)
pdhC1Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex. (430 aa)
pdhA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (327 aa)
acnA1Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (878 aa)
lpd3Dihydrolipoyl dehydrogenase 3. (466 aa)
sucB1Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex. (409 aa)
pdhA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (348 aa)
pdhBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (455 aa)
pdhC2Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (446 aa)
lpdA2Dihydrolipoyl dehydrogenase LpdA. (481 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (429 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
fumCFumarate hydratase class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (463 aa)
lpdVDihydrolipoyl dehydrogenase LpdV. (464 aa)
lpdDihydrolipoyl dehydrogenase Lpd. (468 aa)
sucB2Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (438 aa)
sucA2-oxoglutarate dehydrogenase E1 componentSucA. (998 aa)
sucDsuccinyl-CoA ligase [ADP-forming] subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (300 aa)
sucCsuccinyl-CoA ligase [ADP-forming] subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (398 aa)
mdh2Malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
sdhBSuccinate dehydrogenase iron-sulfur subunit SdhB; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
sdhASuccinate dehydrogenase flavoprotein subunit SdhA; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (613 aa)
AFL54101.1Putative succinate dehydrogenase hydrophobic membrane anchor protein. (124 aa)
AFL54102.1Putative succinate dehydrogenase membrane anchor subunit. (130 aa)
acnA2Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa)
pycPyruvate carboxylase Pyc. (1079 aa)
pckAPhosphoenolpyruvate carboxykinase; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (536 aa)
Your Current Organism:
Sinorhizobium fredii USDA257
NCBI taxonomy Id: 1185652
Other names: S. fredii USDA 257, Sinorhizobium fredii USDA 257, Sinorhizobium fredii str. USDA 257, Sinorhizobium fredii strain USDA 257
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.