STRINGSTRING
fadA fadA ttuC ttuC puuA puuA aceA aceA glcD1 glcD1 glcE1 glcE1 glcF1 glcF1 AFL49119.1 AFL49119.1 vraB vraB glyA glyA AFL49629.1 AFL49629.1 purU1 purU1 ttuD1 ttuD1 glxR glxR hyi hyi gcl gcl gln gln pccB pccB accA11 accA11 bhbA bhbA AFL50152.1 AFL50152.1 bccA1 bccA1 purU2 purU2 sgaA1 sgaA1 glcF2 glcF2 glcE2 glcE2 glcD3 glcD3 bccA2 bccA2 lpdA1 lpdA1 thlA thlA pucG pucG mtkB mtkB mtkA mtkA mcl1 mcl1 sgaA2 sgaA2 garR2 garR2 bccA3 bccA3 acnA1 acnA1 ycsA ycsA ghrA1 ghrA1 katE katE cbbS cbbS cbbL cbbL lpd3 lpd3 AFL51879.1 AFL51879.1 AFL51982.1 AFL51982.1 lpdA2 lpdA2 AFL52049.1 AFL52049.1 gltA gltA AFL52175.1 AFL52175.1 glnA1 glnA1 gcvP gcvP gcvH gcvH gcvT3 gcvT3 gph gph glnA2 glnA2 ytcI ytcI eda eda lpdV lpdV atoB atoB purU3 purU3 fdsD fdsD yrhE yrhE nuoF3 nuoF3 fdsG fdsG lpd lpd mdh2 mdh2 phbA phbA phbB phbB acnA2 acnA2 ttuD2 ttuD2 acsA2 acsA2 glcB glcB ghrA2 ghrA2 gyaR3 gyaR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
fadAPutative acyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
ttuCPutative tartrate dehydrogenase/decarboxylase ttuC. (357 aa)
puuAGamma-glutamylputrescine synthetase PuuA; Belongs to the glutamine synthetase family. (478 aa)
aceAIsocitrate lyase AceA. (429 aa)
glcD1Glycolate oxidase subunit GlcD. (479 aa)
glcE1Glycolate oxidase subunit GlcE. (403 aa)
glcF1Glycolate oxidase iron-sulfur subunit GlcF. (431 aa)
AFL49119.1Putative phosphoglycolate phosphatase. (234 aa)
vraBPutative acetyl-CoA C-acetyltransferase VraB; Belongs to the thiolase-like superfamily. Thiolase family. (399 aa)
glyAPyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
AFL49629.1N-formylglutamate amidohydrolase. (268 aa)
purU1Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
ttuD1Putative hydroxypyruvate reductase TtuD. (422 aa)
glxR2-hydroxy-3-oxopropionate reductase GlxR. (294 aa)
hyiHydroxypyruvate isomerase Hyi; Belongs to the hyi family. (271 aa)
gclGlyoxylate carboligase Gcl; Belongs to the TPP enzyme family. (594 aa)
glnGlutamine synthetase. (344 aa)
pccBpropionyl-CoA carboxylase beta chain. (510 aa)
accA11Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (678 aa)
bhbAmethylmalonyl-CoA mutase BhbA. (712 aa)
AFL50152.1Putative citrate synthase; Belongs to the citrate synthase family. (263 aa)
bccA1Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (555 aa)
purU2Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (296 aa)
sgaA1Serine--glyoxylate aminotransferase SgaA. (396 aa)
glcF2Glycolate oxidase iron-sulfur subunit GlcF. (443 aa)
glcE2Glycolate oxidase subunit GlcE. (387 aa)
glcD3Glycolate oxidase subunit GlcD. (485 aa)
bccA2Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (569 aa)
lpdA1Dihydrolipoyl dehydrogenase LpdA. (479 aa)
thlAacetyl-CoA acetyltransferase ThlA; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
pucGPurine catabolism protein PucG. (370 aa)
mtkBmalate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (299 aa)
mtkAPutative malate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
mcl1malyl-CoA lyase Mcl; Belongs to the HpcH/HpaI aldolase family. (314 aa)
sgaA2Serine--glyoxylate aminotransferase SgaA. (396 aa)
garR22-hydroxy-3-oxopropionate reductase GarR. (295 aa)
bccA3Acetyl-/propionyl-coenzyme A carboxylase alpha chain. (592 aa)
acnA1Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (878 aa)
ycsAPutative tartrate dehydrogenase/decarboxylase. (349 aa)
ghrA1Glyoxylate/hydroxypyruvate reductase A. (307 aa)
katECatalase C; Serves to protect cells from the toxic effects of hydrogen peroxide. (705 aa)
cbbSRibulose bisphosphate carboxylase small chain. (129 aa)
cbbLRibulose bisphosphate carboxylase large chain; RuBisCO catalyzes two reactions: the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site; Belongs to the RuBisCO large chain family. Type I subfamily. (486 aa)
lpd3Dihydrolipoyl dehydrogenase 3. (466 aa)
AFL51879.1Putative lactoylglutathione lyase. (134 aa)
AFL51982.1Hydrolase. (221 aa)
lpdA2Dihydrolipoyl dehydrogenase LpdA. (481 aa)
AFL52049.1Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (399 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (429 aa)
AFL52175.1Putative hydroxypyruvate isomerase protein; Belongs to the hyi family. (264 aa)
glnA1Glutamine synthetase 1. (469 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (954 aa)
gcvHGlycine cleavage system H protein GcvH; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (120 aa)
gcvT3Aminomethyltransferase GcvT. (474 aa)
gphPhosphoglycolate phosphatase Gph; Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress. Belongs to the HAD-like hydrolase superfamily. CbbY/CbbZ/Gph/YieH family. (227 aa)
glnA2Glutamine synthetase GlnA. (454 aa)
ytcIPutative acyl--CoA ligase YtcI. (559 aa)
eda2-dehydro-3-deoxy-phosphogluconate aldolase Eda. (212 aa)
lpdVDihydrolipoyl dehydrogenase LpdV. (464 aa)
atoBacetyl-CoA acetyltransferase AtoB; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
purU3Formyltetrahydrofolate deformylase PurU; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
fdsDNAD-dependent formate dehydrogenase delta subunit FdsD. (76 aa)
yrhEPutative formate dehydrogenase YrhE. (959 aa)
nuoF3NADH-quinone oxidoreductase subunit F. (518 aa)
fdsGPutative NAD-dependent formate dehydrogenase gamma subunit FdsG. (159 aa)
lpdDihydrolipoyl dehydrogenase Lpd. (468 aa)
mdh2Malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
phbAacetyl-CoA acetyltransferase PhbA; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
phbBacetoacetyl-CoA reductase PhbB. (241 aa)
acnA2Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa)
ttuD2Putative hydroxypyruvate reductase TtuD. (491 aa)
acsA2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (723 aa)
ghrA2Glyoxylate/hydroxypyruvate reductase A. (319 aa)
gyaR3Glyoxylate reductase GyaR; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (334 aa)
Your Current Organism:
Sinorhizobium fredii USDA257
NCBI taxonomy Id: 1185652
Other names: S. fredii USDA 257, Sinorhizobium fredii USDA 257, Sinorhizobium fredii str. USDA 257, Sinorhizobium fredii strain USDA 257
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.