STRINGSTRING
mttB1 mttB1 glyA glyA pta pta ackA1 ackA1 fba fba serA1 serA1 ttuD1 ttuD1 serA2 serA2 sgaA1 sgaA1 AFL50468.1 AFL50468.1 pucG pucG mtkB mtkB mtkA mtkA mcl1 mcl1 sgaA2 sgaA2 adhI1 adhI1 dhaK3 dhaK3 adhI2 adhI2 fghA1 fghA1 xoxF1 xoxF1 gfa1 gfa1 cbbA cbbA fbp fbp fghA2 fghA2 eno eno AFL52049.1 AFL52049.1 ackA2 ackA2 mttB2 mttB2 gfa2 gfa2 AFL52976.1 AFL52976.1 mttB3 mttB3 ytcI ytcI serA4 serA4 serC serC AFL53756.1 AFL53756.1 gfa3 gfa3 adhI3 adhI3 AFL53951.1 AFL53951.1 xoxF2 xoxF2 fdsD fdsD yrhE yrhE nuoF3 nuoF3 fdsG fdsG mdh2 mdh2 ttuD2 ttuD2 acsA2 acsA2 gpmA gpmA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
mttB1Trimethylamine methyltransferase MttB; Belongs to the trimethylamine methyltransferase family. (516 aa)
glyAPyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
ptaPhosphate acetyltransferase Pta. (323 aa)
ackA1Acetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (394 aa)
fbaFructose-bisphosphate aldolase Fba; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (348 aa)
serA1D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (345 aa)
ttuD1Putative hydroxypyruvate reductase TtuD. (422 aa)
serA2D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa)
sgaA1Serine--glyoxylate aminotransferase SgaA. (396 aa)
AFL50468.1Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase. (264 aa)
pucGPurine catabolism protein PucG. (370 aa)
mtkBmalate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (299 aa)
mtkAPutative malate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (394 aa)
mcl1malyl-CoA lyase Mcl; Belongs to the HpcH/HpaI aldolase family. (314 aa)
sgaA2Serine--glyoxylate aminotransferase SgaA. (396 aa)
adhI1Alcohol dehydrogenase class-3; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (396 aa)
dhaK3Dihydroxyacetone kinase DhaK. (547 aa)
adhI2Alcohol dehydrogenase class-3; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa)
fghA1S-formylglutathione hydrolase FghA; Serine hydrolase involved in the detoxification of formaldehyde. (280 aa)
xoxF1Putative dehydrogenase XoxF. (600 aa)
gfa1Glutathione-dependent formaldehyde-activating enzyme Gfa; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (189 aa)
cbbAFructose-bisphosphate aldolase CbbA; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa)
fbpFructose-1,6-bisphosphatase class 1; Belongs to the FBPase class 1 family. (349 aa)
fghA2S-formylglutathione hydrolase FghA; Serine hydrolase involved in the detoxification of formaldehyde. (277 aa)
enoEnolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
AFL52049.1Formate dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (399 aa)
ackA2Acetate kinase AckA; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (510 aa)
mttB2Trimethylamine methyltransferase MttB; Belongs to the trimethylamine methyltransferase family. (524 aa)
gfa2Glutathione-dependent formaldehyde-activating enzyme Gfa; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (191 aa)
AFL52976.1Phosphoserine phosphatase. (337 aa)
mttB3Trimethylamine methyltransferase MttB; Belongs to the trimethylamine methyltransferase family. (512 aa)
ytcIPutative acyl--CoA ligase YtcI. (559 aa)
serA4D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa)
serCPhosphoserine aminotransferase SerC; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (392 aa)
AFL53756.1Putative fructose-bisphosphate aldolase class 1. (341 aa)
gfa3Glutathione-dependent formaldehyde-activating enzyme Gfa; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (191 aa)
adhI3Alcohol dehydrogenase class-3; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (375 aa)
AFL53951.1Extracellular solute-binding protein family 3. (286 aa)
xoxF2Putative dehydrogenase XoxF. (634 aa)
fdsDNAD-dependent formate dehydrogenase delta subunit FdsD. (76 aa)
yrhEPutative formate dehydrogenase YrhE. (959 aa)
nuoF3NADH-quinone oxidoreductase subunit F. (518 aa)
fdsGPutative NAD-dependent formate dehydrogenase gamma subunit FdsG. (159 aa)
mdh2Malate dehydrogenase Mdh; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
ttuD2Putative hydroxypyruvate reductase TtuD. (491 aa)
acsA2Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (649 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa)
Your Current Organism:
Sinorhizobium fredii USDA257
NCBI taxonomy Id: 1185652
Other names: S. fredii USDA 257, Sinorhizobium fredii USDA 257, Sinorhizobium fredii str. USDA 257, Sinorhizobium fredii strain USDA 257
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