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argB argB argD1 argD1 ilvB1 ilvB1 ilvE1 ilvE1 AFL49432.1 AFL49432.1 AFL50152.1 AFL50152.1 ilvE2 ilvE2 ilvB2 ilvB2 aatB1 aatB1 acnA1 acnA1 ilvB3 ilvB3 argE argE argC argC gltA gltA icd icd ilvC ilvC ilvH ilvH ilvI ilvI ilvB4 ilvB4 aatA aatA leuA leuA lysC lysC argJ argJ ilvD4 ilvD4 leuD leuD acnA2 acnA2 leuC leuC aatB2 aatB2 leuB leuB asd asd ilvE3 ilvE3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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argBAcetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa)
argD1Acetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa)
ilvB1Acetolactate synthase isozyme 1 large subunit IlvB; Belongs to the TPP enzyme family. (537 aa)
ilvE1Putative branched-chain-amino-acid aminotransferase IlvE. (293 aa)
AFL49432.1Putative AIPM/hcit synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa)
AFL50152.1Putative citrate synthase; Belongs to the citrate synthase family. (263 aa)
ilvE2Putative branched-chain-amino-acid aminotransferase IlvE. (314 aa)
ilvB2Acetolactate synthase large subunit IlvB; Belongs to the TPP enzyme family. (611 aa)
aatB1Aspartate aminotransferase B. (403 aa)
acnA1Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (878 aa)
ilvB3Putative acetolactate synthase large subunit IlvB; Belongs to the TPP enzyme family. (570 aa)
argEAcetylornithine deacetylase ArgE. (375 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa)
gltACitrate synthase GltA; Belongs to the citrate synthase family. (429 aa)
icdIsocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
ilvCKetol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa)
ilvHPutative acetolactate synthase small subunit IlvH. (190 aa)
ilvIAcetolactate synthase isozyme 3 large subunit IlvI. (592 aa)
ilvB4Acetolactate synthase large subunit IlvB; Belongs to the TPP enzyme family. (548 aa)
aatAAspartate aminotransferase A. (456 aa)
leuA2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (569 aa)
lysCAspartokinase LysC; Belongs to the aspartokinase family. (424 aa)
argJArginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa)
ilvD4Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (612 aa)
leuD3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
acnA2Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa)
leuC3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
aatB2Aspartate aminotransferase B. (410 aa)
leuB3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (381 aa)
asdAspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
ilvE3Putative branched-chain-amino-acid aminotransferase IlvE. (364 aa)
Your Current Organism:
Sinorhizobium fredii USDA257
NCBI taxonomy Id: 1185652
Other names: S. fredii USDA 257, Sinorhizobium fredii USDA 257, Sinorhizobium fredii str. USDA 257, Sinorhizobium fredii strain USDA 257
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