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| | metK | S-adenosylmethionine synthase MetK; Belongs to the AdoMet synthase family. (422 aa) |
| | dapE | Succinyl-diaminopimelate desuccinylase DapE; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (398 aa) |
| | dapD-2 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (285 aa) |
| | argB | Acetylglutamate kinase ArgB; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (295 aa) |
| | argD1 | Acetylornithine aminotransferase ArgD; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (399 aa) |
| | argF1 | Ornithine carbamoyltransferase ArgF; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (305 aa) |
| | ilvB1 | Acetolactate synthase isozyme 1 large subunit IlvB; Belongs to the TPP enzyme family. (537 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (434 aa) |
| | tdcB1 | Threonine dehydratase catabolic. (325 aa) |
| | puuA | Gamma-glutamylputrescine synthetase PuuA; Belongs to the glutamine synthetase family. (478 aa) |
| | hisZ | ATP phosphoribosyltransferase regulatory subunit HisZ; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (379 aa) |
| | aroC | Chorismate synthase AroC; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa) |
| | thrB | Homoserine kinase ThrB; Belongs to the pseudomonas-type ThrB family. (326 aa) |
| | thrC | Threonine synthase ThrC. (465 aa) |
| | ilvE1 | Putative branched-chain-amino-acid aminotransferase IlvE. (293 aa) |
| | hisC1 | Histidinol-phosphate aminotransferase. (373 aa) |
| | dapA1 | Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (294 aa) |
| | AFL49432.1 | Putative AIPM/hcit synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (538 aa) |
| | glyA | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa) |
| | fba | Fructose-bisphosphate aldolase Fba; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (348 aa) |
| | AFL49856.1 | Putative DAPA-like lyase; Belongs to the DapA family. (331 aa) |
| | serA1 | D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (345 aa) |
| | arcB1 | Ornithine cyclodeaminase ArcB. (349 aa) |
| | asnB1 | Asparagine synthetase; Glutamine-hydrolyzing. (665 aa) |
| | AFL50073.1 | Putative transketolase N-terminal section. (269 aa) |
| | AFL50074.1 | Putative transketolase C-terminal section. (322 aa) |
| | gln | Glutamine synthetase. (344 aa) |
| | AFL50152.1 | Putative citrate synthase; Belongs to the citrate synthase family. (263 aa) |
| | serA2 | D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (324 aa) |
| | psdht | Phenylserine dehydratase. (337 aa) |
| | ilvE2 | Putative branched-chain-amino-acid aminotransferase IlvE. (314 aa) |
| | tal1 | Putative transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | tktA | Transketolase TktA; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (675 aa) |
| | tpiA2 | Triosephosphate isomerase TpiA; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (236 aa) |
| | AFL50451.1 | Putative transketolase N-terminal section. (273 aa) |
| | AFL50452.1 | Putative transketolase C-terminal section. (322 aa) |
| | AFL50468.1 | Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase. (264 aa) |
| | dapA2 | Dihydrodipicolinate synthase DapA; Belongs to the DapA family. (302 aa) |
| | AFL50721.1 | Shikimate 5-dehydrogenase. (277 aa) |
| | pheC | Cyclohexadienyl dehydratase PheC. (256 aa) |
| | aroE1 | Shikimate dehydrogenase AroE. (291 aa) |
| | AFL50980.1 | Putative cysteine synthase. (336 aa) |
| | AFL50981.1 | Uncharacterized protein y4yA. (457 aa) |
| | AFL51091.1 | Hypothetical protein; Belongs to the DapA family. (319 aa) |
| | ilvB2 | Acetolactate synthase large subunit IlvB; Belongs to the TPP enzyme family. (611 aa) |
| | aatB1 | Aspartate aminotransferase B. (403 aa) |
| | dapAf2 | Dihydrodipicolinate synthase protein; Belongs to the DapA family. (315 aa) |
| | proC1 | Pyrroline-5-carboxylate reductase ProC. (255 aa) |
| | dapA3 | Dihydrodipicolinate synthase DapA; Belongs to the DapA family. (292 aa) |
| | mdeA2 | Methionine gamma-lyase MdeA. (425 aa) |
| | acnA1 | Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (878 aa) |
| | AFL51354.1 | Dihydrodipicolinate synthase; Belongs to the DapA family. (297 aa) |
| | ilvB3 | Putative acetolactate synthase large subunit IlvB; Belongs to the TPP enzyme family. (570 aa) |
| | argE | Acetylornithine deacetylase ArgE. (375 aa) |
| | cbbE1 | Ribulose-phosphate 3-epimerase CbbE; Belongs to the ribulose-phosphate 3-epimerase family. (229 aa) |
| | cbbA | Fructose-bisphosphate aldolase CbbA; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (359 aa) |
| | cbbT1 | Transketolase CbbT; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (681 aa) |
| | AFL51705.1 | Putative threonine dehydratase. (334 aa) |
| | ocd1 | Ornithine cyclodeaminase 1. (329 aa) |
| | asnB2 | Asparagine synthetase [glutamine-hydrolyzing] 1. (653 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase ArgC; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (310 aa) |
| | aroQ1 | 3-dehydroquinate dehydratase AroQ; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (148 aa) |
| | sdaA | L-serine dehydratase SdaA; Belongs to the iron-sulfur dependent L-serine dehydratase family. (466 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase HisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (150 aa) |
| | tpiA3 | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (256 aa) |
| | eno | Enolase Eno; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa) |
| | metC | Putative cystathionine beta-lyase MetC. (395 aa) |
| | cysE | Serine acetyltransferase CysE. (275 aa) |
| | gltA | Citrate synthase GltA; Belongs to the citrate synthase family. (429 aa) |
| | hom | Homoserine dehydrogenase Hom. (440 aa) |
| | trpC | Indole-3-glycerol phosphate synthase TrpC; Belongs to the TrpC family. (271 aa) |
| | trpD | Anthranilate phosphoribosyltransferase TrpD; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (337 aa) |
| | glnA1 | Glutamine synthetase 1. (469 aa) |
| | ilvA | Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (415 aa) |
| | cbs | Putative cystathionine beta-synthase. (346 aa) |
| | cbbE2 | Ribulose-phosphate 3-epimerase CbbE; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa) |
| | argF2 | Ornithine carbamoyltransferase ArgF. (341 aa) |
| | icd | Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase AroH. (457 aa) |
| | rpiA | Ribose-5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (231 aa) |
| | metH1 | Methionine synthase MetH. (338 aa) |
| | metH2 | Methionine synthase MetH. (320 aa) |
| | ilvC | Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (339 aa) |
| | ilvH | Putative acetolactate synthase small subunit IlvH. (190 aa) |
| | ilvI | Acetolactate synthase isozyme 3 large subunit IlvI. (592 aa) |
| | AFL52976.1 | Phosphoserine phosphatase. (337 aa) |
| | ilvB4 | Acetolactate synthase large subunit IlvB; Belongs to the TPP enzyme family. (548 aa) |
| | glnA2 | Glutamine synthetase GlnA. (454 aa) |
| | aatA | Aspartate aminotransferase A. (456 aa) |
| | proC3 | Pyrroline-5-carboxylate reductase ProC; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (272 aa) |
| | prs | Ribose-phosphate pyrophosphokinase Prs; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | leuA | 2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (569 aa) |
| | AFL53253.1 | trpE(G): anthranilate synthase. (729 aa) |
| | metB | Cystathionine gamma-synthase MetB. (384 aa) |
| | lysC | Aspartokinase LysC; Belongs to the aspartokinase family. (424 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa) |
| | argH | Argininosuccinate lyase ArgH. (467 aa) |
| | lysA | Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (422 aa) |
| | tyrC | Protein TyrC. (308 aa) |
| | hisC2 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (368 aa) |
| | aroB | 3-dehydroquinate synthase AroB; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (376 aa) |
| | aroK | Shikimate kinase AroK; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (195 aa) |
| | serA4 | D-3-phosphoglycerate dehydrogenase SerA; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (531 aa) |
| | serC | Phosphoserine aminotransferase SerC; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (392 aa) |
| | cbbT2 | Transketolase CbbT; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (658 aa) |
| | gap | Glyceraldehyde-3-phosphate dehydrogenase Gap; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | pgk | Phosphoglycerate kinase Pgk; Belongs to the phosphoglycerate kinase family. (399 aa) |
| | AFL53756.1 | Putative fructose-bisphosphate aldolase class 1. (341 aa) |
| | pyk | Pyruvate kinase Pyk; Belongs to the pyruvate kinase family. (479 aa) |
| | gltB1 | Glutamate synthase [NADPH] small chain. (485 aa) |
| | gltB2 | Ferredoxin-dependent glutamate synthase 1. (1574 aa) |
| | ltaE | Low specificity L-threonine aldolase LtaE; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (348 aa) |
| | ilvD4 | Dihydroxy-acid dehydratase IlvD; Belongs to the IlvD/Edd family. (612 aa) |
| | metH3 | Methionine synthase MetH; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1256 aa) |
| | arcB3 | Arginase ArcB; Belongs to the arginase family. (307 aa) |
| | tal2 | Putative transaldolase Tal; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa) |
| | aroQ2 | 3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa) |
| | aroE2 | Shikimate dehydrogenase AroE; Belongs to the shikimate dehydrogenase family. (286 aa) |
| | proB | Glutamate 5-kinase ProB; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (393 aa) |
| | proA | Gamma-glutamyl phosphate reductase ProA; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (434 aa) |
| | metA | Homoserine O-succinyltransferase MetA; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit LeuD; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa) |
| | hisC3 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (351 aa) |
| | argG | Argininosuccinate synthase ArgG; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (405 aa) |
| | acnA2 | Aconitate hydratase AcnA; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (896 aa) |
| | dapF | Diaminopimelate epimerase DapF; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (300 aa) |
| | pheAa | Putative chorismate mutase. (112 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit LeuC; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa) |
| | pyc | Pyruvate carboxylase Pyc. (1079 aa) |
| | aatB2 | Aspartate aminotransferase B. (410 aa) |
| | leuB | 3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (381 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase Asd; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa) |
| | aroE3 | Shikimate dehydrogenase AroE; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (286 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase TrpF; Belongs to the TrpF family. (224 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (406 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (279 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphatase HisE. (107 aa) |
| | hisF | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (258 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HisA. (245 aa) |
| | hisH | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (216 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase HisB. (202 aa) |
| | dapB | Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (272 aa) |
| | gpmA | 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (211 aa) |
| | ilvE3 | Putative branched-chain-amino-acid aminotransferase IlvE. (364 aa) |
| | pheA | P-protein PheA. (316 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase AroA; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (448 aa) |
| | tatA2 | Tyrosine aminotransferase TatA. (389 aa) |
| | AFL54658.1 | Putative 5-methylthioadenosine/S-adenosylhomocysteine nucleosidase. (212 aa) |
| | cysK | O-acetylserine sulfhydrylase CysK. (322 aa) |
