STRINGSTRING
yidC yidC secDF1 secDF1 AFL50728.1 AFL50728.1 AFL50732.1 AFL50732.1 nolT nolT AFL50742.1 AFL50742.1 yscN yscN rhcQ rhcQ AFL50746.1 AFL50746.1 AFL50747.1 AFL50747.1 rhcT rhcT AFL51415.1 AFL51415.1 AFL51423.1 AFL51423.1 AFL51424.1 AFL51424.1 AFL51426.1 AFL51426.1 AFL51431.1 AFL51431.1 clpV clpV AFL51488.1 AFL51488.1 virB2 virB2 virB3 virB3 virB4 virB4 virB5 virB5 virB6 virB6 virB7 virB7 virB8 virB8 virB9 virB9 virB10 virB10 virB11 virB11 virD4 virD4 secY secY AFL52034.1 AFL52034.1 bepC bepC tatA1 tatA1 tatB tatB tatC tatC yajC yajC secDF2 secDF2 secA secA ftsY ftsY ffh ffh secB secB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
yidCMembrane protein insertase YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. (593 aa)
secDF1Protein translocase subunit SecDF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (844 aa)
AFL50728.1Putative translocation protein y4yO. (345 aa)
AFL50732.1Putative translocation protein y4yR. (716 aa)
nolTNodulation protein NolT. (266 aa)
AFL50742.1Putative type III secretion component, YOP proteins translocation protein L. (201 aa)
yscNPutative ATP synthase YscN. (448 aa)
rhcQType III secretion system translocation protein, RhcQ. (348 aa)
AFL50746.1Putative translocation protein y4yL. (217 aa)
AFL50747.1Hypothetical protein. (89 aa)
rhcTType III secretion component, RhcT. (273 aa)
AFL51415.1Hypothetical protein. (768 aa)
AFL51423.1Hypothetical protein. (1176 aa)
AFL51424.1Putative conserved membrane protein. (439 aa)
AFL51426.1Hypothetical protein. (152 aa)
AFL51431.1Hypothetical protein. (149 aa)
clpVProtein ClpV; Belongs to the ClpA/ClpB family. (910 aa)
AFL51488.1Lytic transglycosylase catalytic. (223 aa)
virB2Type IV secretion system protein VirB2. (99 aa)
virB3Type IV secretion system protein VirB3. (113 aa)
virB4Type IV secretion system protein VirB4. (793 aa)
virB5Type IV secretion system protein VirB5. (232 aa)
virB6Type IV secretion system protein VirB6. (310 aa)
virB7Type IV secretion system protein VirB7. (91 aa)
virB8Type IV secretion system protein VirB8. (223 aa)
virB9Type IV secretion system protein VirB9. (284 aa)
virB10Type IV secretion system protein VirB10. (390 aa)
virB11Type IV secretion system protein VirB11; Part of the Type IV secretion system. Belongs to the GSP E family. (330 aa)
virD4Type IV secretion system-coupling protein VirD4. (636 aa)
secYProtein translocase subunit SecY; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (446 aa)
AFL52034.1Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (168 aa)
bepCOuter membrane efflux protein BepC. (455 aa)
tatA1Sec-independent protein translocase protein TatA; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. (68 aa)
tatBSec-independent protein translocase protein TatB; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation. (237 aa)
tatCSec-independent protein translocase protein TatC; Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides. (280 aa)
yajCImmunogenic membrane protein YajC; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. (110 aa)
secDF2Protein translocase subunit SecDF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA; Belongs to the SecD/SecF family. SecD subfamily. (855 aa)
secAProtein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (901 aa)
ftsYCell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components. (351 aa)
ffhSignal recognition particle protein Ffh; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual comp [...] (519 aa)
secBProtein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (210 aa)
Your Current Organism:
Sinorhizobium fredii USDA257
NCBI taxonomy Id: 1185652
Other names: S. fredii USDA 257, Sinorhizobium fredii USDA 257, Sinorhizobium fredii str. USDA 257, Sinorhizobium fredii strain USDA 257
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