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| | DCK | Deoxycytidine kinase. (260 aa) |
| | NME6 | Nucleoside diphosphate kinase. (186 aa) |
| | UPP2 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (320 aa) |
| | LOC103088404 | Adenine phosphoribosyltransferase 1-like. (182 aa) |
| | IMPDH2 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa) |
| | GMPR2 | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (440 aa) |
| | NT5C3B | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (300 aa) |
| | LOC103072071 | Nucleoside diphosphate kinase. (141 aa) |
| | AK9 | Adenylate kinase 9. (1810 aa) |
| | ENTPD3 | LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (530 aa) |
| | NT5C3A | 5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa) |
| | PDE11A | Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like. (366 aa) |
| | LOC103070164 | Probable cytidylate kinase-like. (204 aa) |
| | LOC103078149 | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial-like. (100 aa) |
| | AMPD2 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (832 aa) |
| | UPP1 | Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (309 aa) |
| | PDE7B | Phosphodiesterase. (453 aa) |
| | AK8 | Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa) |
| | LOC103072730 | Phosphodiesterase. (576 aa) |
| | NT5C1A | Cytosolic 5'-nucleotidase 1A. (365 aa) |
| | ENTPD6 | Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (456 aa) |
| | DCTPP1 | dCTP pyrophosphatase 1. (201 aa) |
| | GDA | Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (454 aa) |
| | LOC103077453 | Deoxycytidylate deaminase-like. (178 aa) |
| | AK3 | GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa) |
| | UCK1 | Uridine-cytidine kinase 1. (268 aa) |
| | DUT | Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial. (185 aa) |
| | NME3 | Nucleoside diphosphate kinase. (169 aa) |
| | NME4 | Nucleoside diphosphate kinase. (187 aa) |
| | NT5C | 5'(3')-deoxyribonucleotidase, cytosolic type. (218 aa) |
| | CTPS1 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa) |
| | ATIC | Bifunctional purine biosynthesis protein PURH. (592 aa) |
| | ENPP3 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X2. (900 aa) |
| | LOC103081310 | Uncharacterized protein C1683.06c-like. (322 aa) |
| | CTPS2 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa) |
| | ADSSL1 | Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (479 aa) |
| | ENTPD1 | Ectonucleoside triphosphate diphosphohydrolase 1 isoform X1; Belongs to the GDA1/CD39 NTPase family. (526 aa) |
| | LOC103078662 | Deoxyuridine 5'-triphosphate nucleotidohydrolase-like. (150 aa) |
| | ENPP1 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa) |
| | ENTPD4 | Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa) |
| | GMPS | GMP synthase [glutamine-hydrolyzing]. (714 aa) |
| | RRM2 | Ribonucleoside-diphosphate reductase subunit M2 isoform X3. (393 aa) |
| | CDA | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (146 aa) |
| | DGUOK | Deoxyguanosine kinase, mitochondrial isoform X1. (277 aa) |
| | UCK2 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa) |
| | LOC103091485 | Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa) |
| | TK2 | Thymidine kinase 2, mitochondrial isoform X1. (264 aa) |
| | AK4 | Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa) |
| | AK5 | Adenylate kinase isoenzyme 5; Belongs to the adenylate kinase family. (561 aa) |
| | LOC103077831 | Adenylate kinase isoenzyme 1-like; Belongs to the adenylate kinase family. (239 aa) |
| | PDE4C | Phosphodiesterase. (695 aa) |
| | ENTPD2 | Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa) |
| | PDE1A | Phosphodiesterase. (441 aa) |
| | GMPR | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa) |
| | ENTPD8 | Ectonucleoside triphosphate diphosphohydrolase 8 isoform X1; Belongs to the GDA1/CD39 NTPase family. (494 aa) |
| | LOC103075853 | Uracil phosphoribosyltransferase-like. (212 aa) |
| | LOC103086466 | Adenylate kinase-like; Belongs to the adenylate kinase family. (219 aa) |
| | NUDT16 | LOW QUALITY PROTEIN: U8 snoRNA-decapping enzyme. (203 aa) |
| | ENTPD5 | Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family. (428 aa) |
| | PDE4B | Phosphodiesterase. (739 aa) |
| | CANT1 | Soluble calcium-activated nucleotidase 1. (401 aa) |
| | LOC103087577 | Uncharacterized protein LOC103087577. (378 aa) |
| | AMPD1 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (780 aa) |
| | PNP | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (289 aa) |
| | LOC103074627 | Adenylate kinase-like; Belongs to the adenylate kinase family. (216 aa) |
| | LOC103079615 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (254 aa) |
| | LOC103090327 | Uracil phosphoribosyltransferase-like. (212 aa) |
| | LOC103080154 | Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa) |
| | RRM2B | Ribonucleoside-diphosphate reductase subunit M2 B isoform X2. (351 aa) |
| | UCKL1 | Uridine-cytidine kinase; Belongs to the uridine kinase family. (533 aa) |
| | LOC103076117 | Hypoxanthine-guanine-xanthine phosphoribosyltransferase-like. (201 aa) |
| | TK1 | Thymidine kinase. (237 aa) |
| | NT5C1B | Cytosolic 5'-nucleotidase 1B. (483 aa) |
| | ADA | Adenosine deaminase. (363 aa) |
| | HPRT1 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa) |
| | LOC103090598 | Hypoxanthine-guanine-xanthine phosphoribosyltransferase-like. (185 aa) |
| | CMPK1 | UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (228 aa) |
| | NME2 | Nucleoside diphosphate kinase. (152 aa) |
| | LOC103081163 | Nucleoside diphosphate kinase. (152 aa) |
| | NT5E | 5'-nucleotidase isoform X1; Belongs to the 5'-nucleotidase family. (574 aa) |
| | PDE1C | Phosphodiesterase. (769 aa) |
| | APRT | Adenine phosphoribosyltransferase. (180 aa) |
| | NTPCR | Cancer-related nucleoside-triphosphatase homolog. (190 aa) |
| | LOC103091609 | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (510 aa) |
| | PDE1B | Phosphodiesterase. (535 aa) |
| | ADK | Adenosine kinase isoform X1. (362 aa) |
| | PDE10A | Phosphodiesterase. (771 aa) |
| | LOC103084202 | Deoxycytidylate deaminase-like. (178 aa) |
| | CECR1 | LOW QUALITY PROTEIN: adenosine deaminase CECR1. (510 aa) |
| | IMPDH1 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (571 aa) |
| | AK2 | Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa) |
| | CMPK2 | UMP-CMP kinase 2, mitochondrial. (447 aa) |
| | NT5C2 | Cytosolic purine 5'-nucleotidase isoform X1. (570 aa) |
| | HDDC3 | guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase MESH1. (179 aa) |
| | DTYMK | Thymidylate kinase. (212 aa) |
| | NUDT2 | Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Belongs to the Nudix hydrolase family. (147 aa) |
| | AMPD3 | AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (777 aa) |
| | RRM1 | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (798 aa) |
| | LOC103084945 | Adenylosuccinate lyase-like. (385 aa) |
| | XDH | Xanthine dehydrogenase/oxidase isoform X1. (1334 aa) |
| | TYMP | LOW QUALITY PROTEIN: thymidine phosphorylase. (266 aa) |
| | LOC103076897 | Uracil phosphoribosyltransferase homolog. (307 aa) |
| | ITPA | Inosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (209 aa) |
