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NME6 NME6 LOC103088404 LOC103088404 IMPDH2 IMPDH2 GMPR2 GMPR2 LOC103072071 LOC103072071 AK9 AK9 ENTPD3 ENTPD3 NT5C3A NT5C3A PDE11A PDE11A AMPD2 AMPD2 PDE7B PDE7B AK8 AK8 LOC103072730 LOC103072730 NT5C1A NT5C1A ENTPD6 ENTPD6 GDA GDA AK3 AK3 NME3 NME3 NME4 NME4 CTPS1 CTPS1 ATIC ATIC ENPP3 ENPP3 LOC103081310 LOC103081310 CTPS2 CTPS2 ADSSL1 ADSSL1 ENTPD1 ENTPD1 ENPP1 ENPP1 ENTPD4 ENTPD4 GMPS GMPS RRM2 RRM2 LOC103091485 LOC103091485 AK4 AK4 AK5 AK5 LOC103077831 LOC103077831 PDE4C PDE4C ENTPD2 ENTPD2 PDE1A PDE1A GMPR GMPR ENTPD8 ENTPD8 LOC103086466 LOC103086466 NUDT16 NUDT16 ENTPD5 ENTPD5 PDE4B PDE4B CANT1 CANT1 AMPD1 AMPD1 LOC103074627 LOC103074627 LOC103079615 LOC103079615 LOC103080154 LOC103080154 RRM2B RRM2B LOC103076117 LOC103076117 HPRT1 HPRT1 LOC103090598 LOC103090598 NME2 NME2 LOC103081163 LOC103081163 PDE1C PDE1C APRT APRT NTPCR NTPCR LOC103091609 LOC103091609 PDE1B PDE1B ADK ADK PDE10A PDE10A IMPDH1 IMPDH1 AK2 AK2 HDDC3 HDDC3 NUDT2 NUDT2 AMPD3 AMPD3 RRM1 RRM1 LOC103084945 LOC103084945 XDH XDH ITPA ITPA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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NME6Nucleoside diphosphate kinase. (186 aa)
LOC103088404Adenine phosphoribosyltransferase 1-like. (182 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (440 aa)
LOC103072071Nucleoside diphosphate kinase. (141 aa)
AK9Adenylate kinase 9. (1810 aa)
ENTPD3LOW QUALITY PROTEIN: ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (530 aa)
NT5C3A5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
PDE11ADual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A-like. (366 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (832 aa)
PDE7BPhosphodiesterase. (453 aa)
AK8Adenylate kinase 8; Belongs to the adenylate kinase family. (479 aa)
LOC103072730Phosphodiesterase. (576 aa)
NT5C1ACytosolic 5'-nucleotidase 1A. (365 aa)
ENTPD6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (456 aa)
GDAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (454 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (227 aa)
NME3Nucleoside diphosphate kinase. (169 aa)
NME4Nucleoside diphosphate kinase. (187 aa)
CTPS1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (591 aa)
ATICBifunctional purine biosynthesis protein PURH. (592 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 isoform X2. (900 aa)
LOC103081310Uncharacterized protein C1683.06c-like. (322 aa)
CTPS2CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (586 aa)
ADSSL1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (479 aa)
ENTPD1Ectonucleoside triphosphate diphosphohydrolase 1 isoform X1; Belongs to the GDA1/CD39 NTPase family. (526 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa)
GMPSGMP synthase [glutamine-hydrolyzing]. (714 aa)
RRM2Ribonucleoside-diphosphate reductase subunit M2 isoform X3. (393 aa)
LOC103091485Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (172 aa)
AK4Adenylate kinase 4, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity. (223 aa)
AK5Adenylate kinase isoenzyme 5; Belongs to the adenylate kinase family. (561 aa)
LOC103077831Adenylate kinase isoenzyme 1-like; Belongs to the adenylate kinase family. (239 aa)
PDE4CPhosphodiesterase. (695 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2; Belongs to the GDA1/CD39 NTPase family. (495 aa)
PDE1APhosphodiesterase. (441 aa)
GMPRGMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8 isoform X1; Belongs to the GDA1/CD39 NTPase family. (494 aa)
LOC103086466Adenylate kinase-like; Belongs to the adenylate kinase family. (219 aa)
NUDT16LOW QUALITY PROTEIN: U8 snoRNA-decapping enzyme. (203 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5; Belongs to the GDA1/CD39 NTPase family. (428 aa)
PDE4BPhosphodiesterase. (739 aa)
CANT1Soluble calcium-activated nucleotidase 1. (401 aa)
AMPD1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (780 aa)
LOC103074627Adenylate kinase-like; Belongs to the adenylate kinase family. (216 aa)
LOC103079615Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (254 aa)
LOC103080154Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
RRM2BRibonucleoside-diphosphate reductase subunit M2 B isoform X2. (351 aa)
LOC103076117Hypoxanthine-guanine-xanthine phosphoribosyltransferase-like. (201 aa)
HPRT1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (176 aa)
LOC103090598Hypoxanthine-guanine-xanthine phosphoribosyltransferase-like. (185 aa)
NME2Nucleoside diphosphate kinase. (152 aa)
LOC103081163Nucleoside diphosphate kinase. (152 aa)
PDE1CPhosphodiesterase. (769 aa)
APRTAdenine phosphoribosyltransferase. (180 aa)
NTPCRCancer-related nucleoside-triphosphatase homolog. (190 aa)
LOC103091609CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (510 aa)
PDE1BPhosphodiesterase. (535 aa)
ADKAdenosine kinase isoform X1. (362 aa)
PDE10APhosphodiesterase. (771 aa)
IMPDH1Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (571 aa)
AK2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (241 aa)
HDDC3guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase MESH1. (179 aa)
NUDT2Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]; Belongs to the Nudix hydrolase family. (147 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (777 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (798 aa)
LOC103084945Adenylosuccinate lyase-like. (385 aa)
XDHXanthine dehydrogenase/oxidase isoform X1. (1334 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (209 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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