STRINGSTRING
SOS2 SOS2 SHC3 SHC3 FGF16 FGF16 SRC SRC LCP2 LCP2 SOS1 SOS1 PTPN1 PTPN1 GRAP GRAP ANGPT1 ANGPT1 NTRK3 NTRK3 CSK CSK ITK ITK TIAM1 TIAM1 SORT1 SORT1 VAV3 VAV3 PDGFRB PDGFRB FGFBP1 FGFBP1 RAC1 RAC1 VEGFC VEGFC TEC TEC KLB KLB KITLG KITLG CRKL CRKL BCR BCR IRS2 IRS2 PDGFD PDGFD FYN FYN KDR KDR PIK3R3 PIK3R3 VAV2 VAV2 RAPGEF1 RAPGEF1 FGF17 FGF17 PIK3CD PIK3CD TXK TXK LOC103091465 LOC103091465 PLCG2 PLCG2 IGF1 IGF1 CRK CRK SH2B1 SH2B1 LAT LAT TGFA TGFA FGF7 FGF7 SHC4 SHC4 PIK3CG PIK3CG PTPRJ PTPRJ PDGFRA PDGFRA NTRK2 NTRK2 BLNK BLNK CBL CBL GRAP2 GRAP2 PDGFB PDGFB GRB2 GRB2 NGF NGF PIK3R1 PIK3R1 TEK TEK CDH5 CDH5 PIK3R6 PIK3R6 GAB2 GAB2 NTRK1 NTRK1 SHC1 SHC1 PECAM1 PECAM1 NRG3 NRG3 KIT KIT KIDINS220 KIDINS220 PIK3R5 PIK3R5 INSRR INSRR YES1 YES1 FRS3 FRS3 FGF22 FGF22 VEGFA VEGFA INSR INSR LOC103076006 LOC103076006 HBEGF HBEGF FGR FGR FGF10 FGF10 SHC2 SHC2 PGF PGF FGF20 FGF20 PIK3R2 PIK3R2 PTPN22 PTPN22 FER FER MATK MATK NRG2 NRG2 VAV1 VAV1 DOK3 DOK3 AREG AREG VEGFB VEGFB EREG EREG NTF4 NTF4 IRS4 IRS4 EGFR EGFR BCAR1 BCAR1 PDGFC PDGFC BTC BTC EPGN EPGN FLT3LG FLT3LG PLCG1 PLCG1 FGFR4 FGFR4 ERBB2 ERBB2 LYN LYN EGF EGF FGF21 FGF21 FRS2 FRS2 FGF9 FGF9 GAB1 GAB1 NGFR NGFR LOC103081170 LOC103081170 KL KL FIGF FIGF PTK2B PTK2B ANGPT4 ANGPT4 PIK3CB PIK3CB PTK2 PTK2 SH2B3 SH2B3 PIK3CA PIK3CA NRG1 NRG1 FLT4 FLT4 PDGFA PDGFA FGF18 FGF18 FGFR3 FGFR3 GP6 GP6 HRAS HRAS INS INS IRS1 IRS1 FGF1 FGF1 ERBB3 ERBB3 LOC103069787 LOC103069787 FGF6 FGF6 FGF23 FGF23 PAG1 PAG1 FGFRL1 FGFRL1 NTF3 NTF3 ERBB4 ERBB4 IGF1R IGF1R BTK BTK FGF2 FGF2 FGFR2 FGFR2 ANGPT2 ANGPT2 PTPN11 PTPN11 FGFR1 FGFR1 PLCE1 PLCE1 FGF8 FGF8 FLT3 FLT3 FLT1 FLT1 FGF3 FGF3 NRG4 NRG4 FGF5 FGF5 BDNF BDNF
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SOS2Son of sevenless homolog 2-like. (1272 aa)
SHC3SHC-transforming protein 3. (588 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
SRCTyrosine-protein kinase. (548 aa)
LCP2Lymphocyte cytosolic protein 2. (532 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
GRAPGRB2-related adapter protein. (217 aa)
ANGPT1Angiopoietin-1 isoform X1. (498 aa)
NTRK3Tyrosine-protein kinase receptor. (839 aa)
CSKTyrosine-protein kinase. (450 aa)
ITKTyrosine-protein kinase. (620 aa)
TIAM1T-lymphoma invasion and metastasis-inducing protein 1 isoform X1. (1592 aa)
SORT1Sortilin. (831 aa)
VAV3Guanine nucleotide exchange factor VAV3 isoform X1. (875 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1103 aa)
FGFBP1Fibroblast growth factor-binding protein 1. (237 aa)
RAC1Ras-related C3 botulinum toxin substrate 1 isoform X1. (201 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
TECTyrosine-protein kinase. (633 aa)
KLBLOW QUALITY PROTEIN: beta-klotho. (1042 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
CRKLCrk-like protein. (303 aa)
BCRBreakpoint cluster region protein isoform X2. (1272 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
PDGFDPlatelet-derived growth factor D-like isoform X1. (370 aa)
FYNTyrosine-protein kinase. (537 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
VAV2Guanine nucleotide exchange factor VAV2 isoform X1. (878 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1133 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
PIK3CDPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1003 aa)
TXKTyrosine-protein kinase. (525 aa)
LOC103091465Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
CRKAdapter molecule crk isoform X1. (304 aa)
SH2B1SH2B adapter protein 1 isoform X1. (760 aa)
LATLinker for activation of T-cells family member 1. (260 aa)
TGFAProtransforming growth factor alpha. (145 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
SHC4SHC-transforming protein 4 isoform X1. (631 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1126 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta-like. (1155 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
NTRK2Tyrosine-protein kinase receptor. (366 aa)
BLNKB-cell linker protein isoform X1. (459 aa)
CBLE3 ubiquitin-protein ligase CBL. (910 aa)
GRAP2GRB2-related adapter protein 2. (317 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
TEKAngiopoietin-1 receptor isoform X1. (1125 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
GAB2GRB2-associated-binding protein 2. (640 aa)
NTRK1Tyrosine-protein kinase receptor. (795 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
PECAM1Platelet endothelial cell adhesion molecule. (779 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (613 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
KIDINS220Kinase D-interacting substrate of 220 kDa. (1769 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (873 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
YES1Tyrosine-protein kinase. (541 aa)
FRS3Fibroblast growth factor receptor substrate 3 isoform X1. (495 aa)
FGF22LOW QUALITY PROTEIN: fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (229 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
LOC103076006Fibroblast growth factor 11-like; Belongs to the heparin-binding growth factors family. (174 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
FGRTyrosine-protein kinase. (537 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
SHC2SHC-transforming protein 2. (801 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
PTPN22Tyrosine-protein phosphatase non-receptor type 22 isoform X1. (808 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
MATKTyrosine-protein kinase. (485 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (757 aa)
VAV1Proto-oncogene vav isoform X1. (844 aa)
DOK3Docking protein 3. (449 aa)
AREGAmphiregulin isoform X1. (254 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
EREGProepiregulin. (163 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
BCAR1Breast cancer anti-estrogen resistance protein 1 isoform X1. (867 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
BTCProbetacellulin. (178 aa)
EPGNEpigen isoform X1. (153 aa)
FLT3LGFms-related tyrosine kinase 3 ligand isoform X1. (296 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
FGFR4Fibroblast growth factor receptor. (800 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LYNTyrosine-protein kinase. (516 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
GAB1GRB2-associated-binding protein 1 isoform X1. (723 aa)
NGFRTumor necrosis factor receptor superfamily member 16. (427 aa)
LOC103081170Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (465 aa)
KLKlotho. (1012 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
ANGPT4Angiopoietin-4. (498 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
PTK2Focal adhesion kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1003 aa)
SH2B3SH2B adapter protein 3. (573 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Belongs to the PI3/PI4-kinase family. (1073 aa)
NRG1Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (641 aa)
FLT4Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1594 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
GP6Platelet glycoprotein VI. (365 aa)
HRASGTPase HRas isoform X1. (189 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
LOC103069787BDNF/NT-3 growth factors receptor-like isoform X1. (553 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
PAG1Phosphoprotein associated with glycosphingolipid-enriched microdomains 1. (519 aa)
FGFRL1Fibroblast growth factor receptor-like 1. (545 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (266 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
BTKTyrosine-protein kinase. (659 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
FGFR2Fibroblast growth factor receptor. (839 aa)
ANGPT2Angiopoietin-2. (496 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
PLCE1Phosphoinositide phospholipase C. (2303 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
FLT3Receptor-type tyrosine-protein kinase FLT3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (973 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
NRG4Pro-neuregulin-4, membrane-bound isoform. (116 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (266 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (248 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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