STRINGSTRING
BMP4 BMP4 ACVR1C ACVR1C INHA INHA SKI SKI ACVR1 ACVR1 SMAD3 SMAD3 BMP7 BMP7 GDF5 GDF5 SMAD6 SMAD6 SMURF1 SMURF1 ACVRL1 ACVRL1 LTBP1 LTBP1 GDF6 GDF6 ACVR1B ACVR1B GDF2 GDF2 SMURF2 SMURF2 ACVR2A ACVR2A TGFBR2 TGFBR2 BMPR1A BMPR1A FST FST TGFB3 TGFB3 LOC103088826 LOC103088826 TGFB1 TGFB1 SMAD5 SMAD5 TGFBR1 TGFBR1 ZFYVE9 ZFYVE9 GREM1 GREM1 GDF7 GDF7 ACVR2B ACVR2B BMP10 BMP10 SMAD9 SMAD9 BMPR1B BMPR1B NOG NOG SMAD4 SMAD4 SKIL SKIL BMP6 BMP6 SMAD7 SMAD7 MSTN MSTN INHBE INHBE GDF11 GDF11 SMAD2 SMAD2 INHBA INHBA INHBC INHBC SMAD1 SMAD1 BMPR2 BMPR2 CHRD CHRD TGFBR3 TGFBR3 BMP2 BMP2 INHBB INHBB TGFB2 TGFB2 BMP5 BMP5 ZFYVE16 ZFYVE16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa)
SKISki oncogene. (731 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
GDF5Growth/differentiation factor 5. (499 aa)
SMAD6Mothers against decapentaplegic homolog. (495 aa)
SMURF1E3 ubiquitin-protein ligase SMURF1. (720 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
LTBP1Latent-transforming growth factor beta-binding protein 1 isoform X1. (1713 aa)
GDF6Growth/differentiation factor 6. (461 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
GDF2Growth/differentiation factor 2. (431 aa)
SMURF2E3 ubiquitin-protein ligase. (747 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (513 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FSTFollistatin isoform X1. (344 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
LOC103088826Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (143 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
ZFYVE9Zinc finger FYVE domain-containing protein. (1420 aa)
GREM1Gremlin. (184 aa)
GDF7Growth/differentiation factor 7. (457 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (512 aa)
BMP10Bone morphogenetic protein 10. (421 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
SKILSki-like protein isoform X1. (683 aa)
BMP6Bone morphogenetic protein 6. (495 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
MSTNGrowth/differentiation factor 8. (366 aa)
INHBEInhibin beta E chain. (351 aa)
GDF11Growth/differentiation factor 11. (404 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (430 aa)
INHBCInhibin beta C chain. (352 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (958 aa)
TGFBR3Transforming growth factor beta receptor type 3. (851 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
INHBBInhibin beta B chain. (511 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (454 aa)
ZFYVE16Zinc finger FYVE domain-containing protein 16 isoform X1. (1546 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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