STRINGSTRING
WDHD1 WDHD1 ATM ATM ATRIP ATRIP NBN NBN TOP3A TOP3A RBBP8 RBBP8 RAD51D RAD51D LOC103076219 LOC103076219 ATR ATR HUS1 HUS1 RAD51C RAD51C WRN WRN RAD9B RAD9B RAD51B RAD51B RPA3 RPA3 MRE11A MRE11A BRCA1 BRCA1 PALB2 PALB2 RAD9A RAD9A TOP3B TOP3B SLX4 SLX4 DMC1 DMC1 SLX1A SLX1A EME2 EME2 MEIOB MEIOB CLSPN CLSPN BARD1 BARD1 RPA1 RPA1 RPA4 RPA4 XRCC3 XRCC3 RAD17 RAD17 DNA2 DNA2 TOPBP1 TOPBP1 RPA2 RPA2 RAD50 RAD50 MUS81 MUS81 CHEK2 CHEK2 RAD51 RAD51 LOC103075745 LOC103075745 EXO1 EXO1 RTEL1 RTEL1 BRCA2 BRCA2 GEN1 GEN1 RMI2 RMI2 EME1 EME1 RECQL4 RECQL4 BRIP1 BRIP1 TP53BP1 TP53BP1 RMI1 RMI1 LOC103073470 LOC103073470 RAD1 RAD1 RHNO1 RHNO1 FANCM FANCM XRCC2 XRCC2 ANKRD32 ANKRD32 RAD52 RAD52 BLM BLM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WDHD1WD repeat and HMG-box DNA-binding protein 1. (1130 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ATRIPLOW QUALITY PROTEIN: ATR-interacting protein. (794 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1003 aa)
RBBP8DNA endonuclease RBBP8. (892 aa)
RAD51DDNA repair protein RAD51 homolog 4. (350 aa)
LOC103076219DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2633 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
RAD51CDNA repair protein RAD51 homolog 3. (337 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (413 aa)
RAD51BDNA repair protein RAD51 homolog 2. (252 aa)
RPA3Replication protein A 14 kDa subunit. (121 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa)
PALB2Partner and localizer of BRCA2. (1192 aa)
RAD9ACell cycle checkpoint control protein; Belongs to the rad9 family. (419 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (861 aa)
SLX4LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4. (1776 aa)
DMC1Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (340 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (271 aa)
EME2LOW QUALITY PROTEIN: probable crossover junction endonuclease EME2. (377 aa)
MEIOBMeiosis-specific with OB domain-containing protein isoform X1. (471 aa)
CLSPNClaspin isoform X1. (1335 aa)
BARD1BRCA1-associated RING domain protein 1 isoform X1. (776 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
RPA4Replication protein A 30 kDa subunit. (259 aa)
XRCC3DNA repair protein XRCC3. (346 aa)
RAD17Cell cycle checkpoint protein RAD17. (709 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa)
TOPBP1DNA topoisomerase 2-binding protein 1. (1471 aa)
RPA2Replication protein A 32 kDa subunit. (270 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
MUS81Crossover junction endonuclease MUS81. (551 aa)
CHEK2Serine/threonine-protein kinase Chk2 isoform X1. (547 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
LOC103075745Tudor domain-containing protein 3-like isoform X1. (651 aa)
EXO1Exonuclease 1. (835 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1249 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa)
GEN1Flap endonuclease GEN homolog 1. (905 aa)
RMI2recQ-mediated genome instability protein 2. (149 aa)
EME1Crossover junction endonuclease EME1 isoform X1. (589 aa)
RECQL4ATP-dependent DNA helicase Q4. (1224 aa)
BRIP1LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1241 aa)
TP53BP1Tumor suppressor p53-binding protein 1 isoform X1. (1975 aa)
RMI1recQ-mediated genome instability protein 1 isoform X1. (626 aa)
LOC103073470Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa)
RAD1Cell cycle checkpoint protein RAD1. (279 aa)
RHNO1RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 isoform X1. (240 aa)
FANCMLOW QUALITY PROTEIN: Fanconi anemia group M protein. (2076 aa)
XRCC2DNA repair protein XRCC2-like. (280 aa)
ANKRD32Ankyrin repeat domain-containing protein 32 isoform X2. (1055 aa)
RAD52LOW QUALITY PROTEIN: DNA repair protein RAD52 homolog. (407 aa)
BLMBloom syndrome protein isoform X1. (1430 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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