STRINGSTRING
LOC103081641 LOC103081641 ITGAV ITGAV LOC103070824 LOC103070824 CCL3 CCL3 POU4F2 POU4F2 MAP4K1 MAP4K1 MAP3K8 MAP3K8 NPHS1 NPHS1 PTPN6 PTPN6 FGF8 FGF8 MAP3K9 MAP3K9 CCR5 CCR5 SPRY1 SPRY1 MAPKAPK2 MAPKAPK2 FGF2 FGF2 TNFSF11 TNFSF11 ADRA2B ADRA2B LOC103069061 LOC103069061 STRADB STRADB FGF23 FGF23 MAP3K15 MAP3K15 MAPK6 MAPK6 SMAD1 SMAD1 BRAF BRAF MAP4K4 MAP4K4 CDC42EP5 CDC42EP5 PBK PBK ADRA1A ADRA1A NOX1 NOX1 FGFR3 FGFR3 MAPK13 MAPK13 FGF18 FGF18 MEF2C MEF2C MAPK14 MAPK14 LOC103089656 LOC103089656 BRAP BRAP SPRY2 SPRY2 HSF1 HSF1 MAPK4 MAPK4 CTNNB1 CTNNB1 PAK3 PAK3 TLR3 TLR3 DUSP10 DUSP10 ITPKB ITPKB IGFBP4 IGFBP4 NOD1 NOD1 NFKB1 NFKB1 CAV3 CAV3 MAPK10 MAPK10 MAPK9 MAPK9 AVP AVP EGF EGF BANK1 BANK1 TNIK TNIK MAPK15 MAPK15 EPGN EPGN MAP3K11 MAP3K11 MEN1 MEN1 KARS KARS HTR2B HTR2B MYD88 MYD88 RHBDD3 RHBDD3 MAP4K2 MAP4K2 MAP2K2 MAP2K2 FGF10 FGF10 NOD2 NOD2 SCG2 SCG2 PRKCE PRKCE NF2 NF2 PLVAP PLVAP TGFB1 TGFB1 LOC103079692 LOC103079692 MEF2A MEF2A MAP3K10 MAP3K10 DAXX DAXX MAP3K6 MAP3K6 IQGAP3 IQGAP3 PEA15 PEA15 CTSH CTSH STK3 STK3 CARD9 CARD9 MAP3K4 MAP3K4 TF TF TRIB1 TRIB1 CCL2 CCL2 WNT5A WNT5A ASH1L ASH1L MAP3K14 MAP3K14 MYC MYC TLR8 TLR8 MAP2K4 MAP2K4 ZFP36L1 ZFP36L1 PPM1L PPM1L SHANK3 SHANK3 MAPK12 MAPK12 MAPK8IP2 MAPK8IP2 TAOK3 TAOK3 MAPK8IP1 MAPK8IP1 SETX SETX TLR7 TLR7 ANKRD10 ANKRD10 TAOK2 TAOK2 LOC103090748 LOC103090748 NLK NLK RIPK1 RIPK1 MAPK3 MAPK3 SOX9 SOX9 MAP3K7 MAP3K7 YWHAE YWHAE PAFAH1B1 PAFAH1B1 TAOK1 TAOK1 MAPK11 MAPK11 C1QL4 C1QL4 MAP3K13 MAP3K13 ABL1 ABL1 CAV1 CAV1 NENF NENF TMEM248 TMEM248 RAPGEF1 RAPGEF1 SORBS3 SORBS3 ATF2 ATF2 TBC1D10C TBC1D10C ARAF ARAF KDR KDR ZFP36 ZFP36 HESX1 HESX1 NF1 NF1 RET RET MAPK1 MAPK1 MAPK7 MAPK7 WNK4 WNK4 MAP2K1 MAP2K1 MBP MBP FLCN FLCN MAP2K3 MAP2K3 PTPLAD1 PTPLAD1 IGFBP3 IGFBP3 LOC103080627 LOC103080627 MAP2K5 MAP2K5 SMAD3 SMAD3 RIPK2 RIPK2 ERCC6 ERCC6 EDN1 EDN1 GRB10 GRB10 ZFP36L2 ZFP36L2 AR AR LOC103070587 LOC103070587 PTPRC PTPRC LRRK2 LRRK2 IL1B IL1B MAP4K3 MAP4K3 MAP4K5 MAP4K5 MAPK8 MAPK8 LOC103073248 LOC103073248
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
LOC103081641LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa)
ITGAVIntegrin alpha-V; Belongs to the integrin alpha chain family. (1311 aa)
LOC103070824Leucine-rich repeat serine/threonine-protein kinase 2-like. (1609 aa)
CCL3LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 3. (88 aa)
POU4F2POU domain protein. (408 aa)
MAP4K1Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (468 aa)
NPHS1LOW QUALITY PROTEIN: nephrin. (1244 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
MAP3K9Mitogen-activated protein kinase kinase kinase 9 isoform X1. (1125 aa)
CCR5c-C chemokine receptor type 5; Belongs to the G-protein coupled receptor 1 family. (352 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
MAPKAPK2MAP kinase-activated protein kinase 2; Belongs to the protein kinase superfamily. (388 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
ADRA2Balpha-2B adrenergic receptor. (440 aa)
LOC103069061Mitogen-activated protein kinase kinase kinase 5-like. (127 aa)
STRADBSTE20-related kinase adapter protein beta isoform X1. (418 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
MAP3K15Mitogen-activated protein kinase kinase kinase 15. (1193 aa)
MAPK6Mitogen-activated protein kinase 6. (722 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
MAP4K4Mitogen-activated protein kinase kinase kinase kinase 4 isoform X1. (1264 aa)
CDC42EP5Cdc42 effector protein 5. (153 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (323 aa)
ADRA1Aalpha-1A adrenergic receptor. (467 aa)
NOX1LOW QUALITY PROTEIN: NADPH oxidase 1. (562 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
MAPK13Mitogen-activated protein kinase. (366 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
MAPK14Mitogen-activated protein kinase. (360 aa)
LOC103089656Mitogen-activated protein kinase kinase kinase. (1017 aa)
BRAPBRCA1-associated protein. (592 aa)
SPRY2Protein sprouty homolog 2 isoform X1. (315 aa)
HSF1Heat shock factor protein 1 isoform X1. (553 aa)
MAPK4Mitogen-activated protein kinase 4. (586 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (579 aa)
TLR3LOW QUALITY PROTEIN: toll-like receptor 3; Belongs to the Toll-like receptor family. (956 aa)
DUSP10Dual specificity protein phosphatase 10 isoform X1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (483 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (942 aa)
IGFBP4Insulin-like growth factor-binding protein 4. (258 aa)
NOD1Nucleotide-binding oligomerization domain-containing protein 1. (953 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
MAPK10Mitogen-activated protein kinase. (464 aa)
MAPK9Mitogen-activated protein kinase. (424 aa)
AVPVasopressin-neurophysin 2-copeptin; Belongs to the vasopressin/oxytocin family. (166 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
BANK1B-cell scaffold protein with ankyrin repeats. (751 aa)
TNIKTraf2 and NCK-interacting protein kinase isoform X1. (1360 aa)
MAPK15LOW QUALITY PROTEIN: mitogen-activated protein kinase 15. (716 aa)
EPGNEpigen isoform X1. (153 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (858 aa)
MEN1Menin isoform X1. (631 aa)
KARSLysine--tRNA ligase. (625 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
RHBDD3Rhomboid domain-containing protein 3. (386 aa)
MAP4K2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (842 aa)
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
SCG2Secretogranin-2. (616 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. (493 aa)
NF2LOW QUALITY PROTEIN: merlin. (592 aa)
PLVAPPlasmalemma vesicle-associated protein. (440 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
LOC103079692Mitogen-activated protein kinase kinase kinase MLT-like isoform X1. (800 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (503 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (948 aa)
DAXXDeath domain-associated protein 6. (757 aa)
MAP3K6Mitogen-activated protein kinase kinase kinase 6. (1301 aa)
IQGAP3Ras GTPase-activating-like protein IQGAP3. (1612 aa)
PEA15Astrocytic phosphoprotein PEA-15. (130 aa)
CTSHPro-cathepsin H isoform X1; Belongs to the peptidase C1 family. (335 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
CARD9Caspase recruitment domain-containing protein 9. (539 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1644 aa)
TFSerotransferrin; Belongs to the transferrin family. (709 aa)
TRIB1Tribbles homolog 1. (372 aa)
CCL2C-C motif chemokine. (99 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
ASH1LHistone-lysine N-methyltransferase ASH1L. (2964 aa)
MAP3K14Mitogen-activated protein kinase kinase kinase 14. (959 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (440 aa)
TLR8Toll-like receptor 8; Belongs to the Toll-like receptor family. (1035 aa)
MAP2K4Dual specificity mitogen-activated protein kinase kinase 4 isoform X1; Belongs to the protein kinase superfamily. (410 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1-like. (338 aa)
PPM1LProtein phosphatase 1L. (583 aa)
SHANK3SH3 and multiple ankyrin repeat domains protein 3. (1586 aa)
MAPK12Mitogen-activated protein kinase. (367 aa)
MAPK8IP2c-Jun-amino-terminal kinase-interacting protein 2. (808 aa)
TAOK3Serine/threonine-protein kinase TAO3 isoform X1. (898 aa)
MAPK8IP1c-Jun-amino-terminal kinase-interacting protein 1. (710 aa)
SETXProbable helicase senataxin. (2691 aa)
TLR7Toll-like receptor 7 isoform X1. (1067 aa)
ANKRD10Ankyrin repeat domain-containing protein 10 isoform X1. (418 aa)
TAOK2Serine/threonine-protein kinase TAO2 isoform X1. (1235 aa)
LOC103090748Zinc finger protein 36, C3H1 type-like 1-like. (226 aa)
NLKMitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (523 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
SOX9Transcription factor SOX-9 isoform X1. (509 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
YWHAE14-3-3 protein epsilon; Belongs to the 14-3-3 family. (255 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
TAOK1Serine/threonine-protein kinase TAO1 isoform X1. (1001 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
C1QL4Complement C1q-like protein 4. (238 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (968 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
NENFNeudesin; Belongs to the cytochrome b5 family. (172 aa)
TMEM248Transmembrane protein 248. (332 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1 isoform X1. (1133 aa)
SORBS3Vinexin isoform X2. (668 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2 isoform X1. (505 aa)
TBC1D10CCarabin. (442 aa)
ARAFSerine/threonine-protein kinase A-Raf isoform X2. (609 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
ZFP36Tristetraprolin. (325 aa)
HESX1Homeobox expressed in ES cells 1. (186 aa)
NF1Neurofibromin isoform X1. (2841 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1026 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (774 aa)
WNK4Serine/threonine-protein kinase WNK4. (1232 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
MBPMyelin basic protein isoform X1. (185 aa)
FLCNFolliculin. (579 aa)
MAP2K3Dual specificity mitogen-activated protein kinase kinase 3; Belongs to the protein kinase superfamily. (347 aa)
PTPLAD1Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (362 aa)
IGFBP3Insulin-like growth factor-binding protein 3 isoform X2. (299 aa)
LOC103080627Lysine--tRNA ligase. (509 aa)
MAP2K5Dual specificity mitogen-activated protein kinase kinase 5-like. (282 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
ERCC6DNA excision repair protein ERCC-6. (1485 aa)
EDN1Endothelin-1. (202 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (588 aa)
ZFP36L2LOW QUALITY PROTEIN: zinc finger protein 36, C3H1 type-like 2. (487 aa)
ARAndrogen receptor. (888 aa)
LOC103070587Tyrosine-protein kinase ABL1-like. (126 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1121 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2-like. (920 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
MAP4K3Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (894 aa)
MAP4K5Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (851 aa)
MAPK8Mitogen-activated protein kinase. (427 aa)
LOC103073248Dual specificity mitogen-activated protein kinase kinase 5-like. (160 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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