STRINGSTRING
HUS1 HUS1 ATR ATR ZNF827 ZNF827 BLM BLM MRE11A MRE11A TERF2 TERF2 PIF1 PIF1 POT1 POT1 TINF2 TINF2 WRN WRN RAD51C RAD51C LOC103076219 LOC103076219 FBXO4 FBXO4 PCNA PCNA INO80E INO80E LOC103086580 LOC103086580 ATM ATM ACTR8 ACTR8 RIF1 RIF1 SMC5 SMC5 NBN NBN RAD51D RAD51D SLX4 SLX4 TELO2 TELO2 TERF1 TERF1 PARP3 PARP3 XRCC6 XRCC6 MCRS1 MCRS1 CCNE2 CCNE2 ZBTB48 ZBTB48 SLX1A SLX1A YY1 YY1 RPA1 RPA1 NFRKB NFRKB ACD ACD CTC1 CTC1 WRAP53 WRAP53 XRCC3 XRCC3 NSMCE2 NSMCE2 XRCC1 XRCC1 DNA2 DNA2 TPRKB TPRKB INO80 INO80 ERCC1 ERCC1 RAD50 RAD50 DCLRE1C DCLRE1C UPF1 UPF1 RAD51 RAD51 ERCC4 ERCC4 RUVBL2 RUVBL2 TEP1 TEP1 APEX1 APEX1 PRKDC PRKDC TERF2IP TERF2IP NHP2 NHP2 RTEL1 RTEL1 BRCA2 BRCA2 DCLRE1B DCLRE1B TFPT TFPT XRCC5 XRCC5 GAR1 GAR1 SMC6 SMC6 ORAOV1 ORAOV1 PINX1 PINX1 RUVBL1 RUVBL1 ACTL6A ACTL6A RECQL4 RECQL4 DKC1 DKC1 UCHL5 UCHL5 PTGES3 PTGES3 INO80D INO80D CCNE1 CCNE1 OBFC1 OBFC1 DCLRE1A DCLRE1A TERT TERT
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HUS1Checkpoint protein; Belongs to the HUS1 family. (280 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2633 aa)
ZNF827Zinc finger protein 827. (1073 aa)
BLMBloom syndrome protein isoform X1. (1430 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (539 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (641 aa)
POT1Protection of telomeres protein 1. (785 aa)
TINF2TERF1-interacting nuclear factor 2. (453 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1439 aa)
RAD51CDNA repair protein RAD51 homolog 3. (337 aa)
LOC103076219DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
FBXO4F-box only protein 4. (387 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
INO80EINO80 complex subunit E. (244 aa)
LOC103086580Protein ZNF365-like. (408 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (624 aa)
RIF1Telomere-associated protein RIF1 isoform X1. (2467 aa)
SMC5Structural maintenance of chromosomes protein 5. (1106 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa)
RAD51DDNA repair protein RAD51 homolog 4. (350 aa)
SLX4LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4. (1776 aa)
TELO2Telomere length regulation protein TEL2 homolog. (825 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (437 aa)
PARP3Poly [ADP-ribose] polymerase. (536 aa)
XRCC6X-ray repair cross-complementing protein 6 isoform X1. (609 aa)
MCRS1Microspherule protein 1 isoform X1. (475 aa)
CCNE2G1/S-specific cyclin-E2; Belongs to the cyclin family. (404 aa)
ZBTB48Zinc finger and BTB domain-containing protein 48. (688 aa)
SLX1AStructure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. (271 aa)
YY1Transcriptional repressor protein YY1. (412 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
NFRKBNuclear factor related to kappa-B-binding protein isoform X2. (1308 aa)
ACDAdrenocortical dysplasia protein homolog. (454 aa)
CTC1CST complex subunit CTC1. (1210 aa)
WRAP53Telomerase Cajal body protein 1 isoform X2. (543 aa)
XRCC3DNA repair protein XRCC3. (346 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (246 aa)
XRCC1DNA repair protein XRCC1. (628 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (1063 aa)
TPRKBEKC/KEOPS complex subunit TPRKB isoform X1; Belongs to the CGI121/TPRKB family. (175 aa)
INO80DNA helicase INO80. (1564 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (294 aa)
RAD50DNA repair protein RAD50 isoform X1. (1312 aa)
DCLRE1CProtein artemis. (710 aa)
UPF1Regulator of nonsense transcripts 1. (1110 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
ERCC4DNA repair endonuclease XPF. (916 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
TEP1Telomerase protein component 1 isoform X1. (2626 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (320 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4131 aa)
TERF2IPTelomeric repeat-binding factor 2-interacting protein 1. (399 aa)
NHP2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1249 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa)
DCLRE1B5' exonuclease Apollo. (539 aa)
TFPTTCF3 fusion partner homolog isoform X1. (253 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (221 aa)
SMC6Structural maintenance of chromosomes protein 6. (1097 aa)
ORAOV1Oral cancer-overexpressed protein 1. (137 aa)
PINX1PIN2/TERF1-interacting telomerase inhibitor 1. (314 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
ACTL6AActin-like protein 6A isoform X1; Belongs to the actin family. (468 aa)
RECQL4ATP-dependent DNA helicase Q4. (1224 aa)
DKC1H/ACA ribonucleoprotein complex subunit 4. (420 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
PTGES3Prostaglandin E synthase 3 isoform X1. (160 aa)
INO80DLOW QUALITY PROTEIN: INO80 complex subunit D. (1032 aa)
CCNE1G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
OBFC1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (368 aa)
DCLRE1ADNA cross-link repair 1A protein. (1054 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1127 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.