STRINGSTRING
PRKCB PRKCB PRIMA1 PRIMA1 SNCAIP SNCAIP DVL1 DVL1 P2RX7 P2RX7 SLC29A4 SLC29A4 STXBP3 STXBP3 CPLX3 CPLX3 ADCY1 ADCY1 ATP2A2 ATP2A2 CACNB2 CACNB2 GABRA2 GABRA2 BACE1 BACE1 SLC1A2 SLC1A2 CHAT CHAT HCRT HCRT CSPG5 CSPG5 LRRK2 LRRK2 SYNPR SYNPR BCHE BCHE GAD1 GAD1 ACHE ACHE PDZD11 PDZD11 SYT5 SYT5 CTBP2 CTBP2 ADRA2A ADRA2A LOC103083735 LOC103083735 CLN8 CLN8 GIPC1 GIPC1 RAB5A RAB5A CNR1 CNR1 SLC1A7 SLC1A7 SLC18A1 SLC18A1 ABAT ABAT LOC103088976 LOC103088976 PFN2 PFN2 MCTP1 MCTP1 LIN7B LIN7B UNC13C UNC13C STXBP2 STXBP2 ADORA2B ADORA2B VPS18 VPS18 UNC13A UNC13A SYT9 SYT9 SNAP23 SNAP23 COMT COMT ATP1A2 ATP1A2 LOC103078014 LOC103078014 RAB3B RAB3B SLC6A2 SLC6A2 LOC103080275 LOC103080275 RAP1B RAP1B LIN7C LIN7C SLC29A2 SLC29A2 CACNB4 CACNB4 DAGLA DAGLA SLC22A1 SLC22A1 PREPL PREPL GIPC3 GIPC3 LRRC1 LRRC1 LOC103077822 LOC103077822 GIPC2 GIPC2 RAB3A RAB3A PSEN1 PSEN1 DTNBP1 DTNBP1 KCNJ10 KCNJ10 TOR1A TOR1A LOC103070824 LOC103070824 SYN1 SYN1 PNKD PNKD SYN2 SYN2 DBH DBH BAIAP3 BAIAP3 SLC4A8 SLC4A8 HNMT HNMT SLC6A4 SLC6A4 LOC103073665 LOC103073665 NT5DC2 NT5DC2 STX1B STX1B PRRT2 PRRT2 ALDH5A1 ALDH5A1 DRD2 DRD2 ACTN1 ACTN1 DOC2A DOC2A CADPS CADPS STX4 STX4 CLN3 CLN3 STXBP5 STXBP5 PARK7 PARK7 RIMS3 RIMS3 UNC13B UNC13B DOC2B DOC2B RPH3AL RPH3AL NT5DC3 NT5DC3 MOXD1 MOXD1 STX2 STX2 GDNF GDNF CASK CASK MAOB MAOB STX3 STX3 SLC22A2 SLC22A2 SLC22A3 SLC22A3 LIN7A LIN7A SYT2 SYT2 GRIN3A GRIN3A VAMP2 VAMP2 SNAPIN SNAPIN ITGB3 ITGB3 SLC29A1 SLC29A1 MAOA MAOA RIMS1 RIMS1 GPM6B GPM6B AGTPBP1 AGTPBP1 SNAP47 SNAP47 SLC5A7 SLC5A7 SLC44A4 SLC44A4 PARK2 PARK2 RAP1A RAP1A SYP SYP GSK3B GSK3B LOC103079561 LOC103079561 DAGLB DAGLB FLOT1 FLOT1 ERC2 ERC2 SYN3 SYN3 LOC103071815 LOC103071815 PPFIA3 PPFIA3 HRH3 HRH3 SCRIB SCRIB MCTP2 MCTP2 ITGB1 ITGB1 CADPS2 CADPS2 SLC6A3 SLC6A3 CHRNA5 CHRNA5 OTOF OTOF STXBP1 STXBP1 ASIC1 ASIC1 NF1 NF1 SNAP25 SNAP25 CPLX4 CPLX4 SYT1 SYT1 STX11 STX11 SYT12 SYT12 SNAP29 SNAP29 STXBP5L STXBP5L GIT1 GIT1 SLC6A11 SLC6A11 NLGN1 NLGN1 LOC103082698 LOC103082698 FBXL20 FBXL20 STX19 STX19 CPLX2 CPLX2 TH TH APBA1 APBA1 RIMS2 RIMS2 LOC103069601 LOC103069601 GPER1 GPER1 SLC17A8 SLC17A8 SV2A SV2A CHRM2 CHRM2 SYT8 SYT8 STX1A STX1A BRAF BRAF DGKI DGKI PDE1B PDE1B SLC18A2 SLC18A2 RPH3A RPH3A LOC103087242 LOC103087242
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
PRIMA1Proline-rich membrane anchor 1 isoform X1. (153 aa)
SNCAIPSynphilin-1 isoform X1. (968 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X2. (699 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
SLC29A4Equilibrative nucleoside transporter 4. (523 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
CPLX3Complexin-3. (158 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1039 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (651 aa)
GABRA2LOW QUALITY PROTEIN: gamma-aminobutyric acid receptor subunit alpha-2; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (456 aa)
BACE1Beta-secretase 1 isoform X1; Belongs to the peptidase A1 family. (498 aa)
SLC1A2Amino acid transporter. (565 aa)
CHATCholine O-acetyltransferase; Belongs to the carnitine/choline acetyltransferase family. (641 aa)
HCRTOrexin; Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Belongs to the orexin family. (131 aa)
CSPG5LOW QUALITY PROTEIN: chondroitin sulfate proteoglycan 5. (572 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2-like. (920 aa)
SYNPRSynaptoporin isoform X1. (276 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (643 aa)
GAD1Glutamate decarboxylase 1 isoform X1. (594 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (615 aa)
PDZD11PDZ domain-containing protein 11. (174 aa)
SYT5Synaptotagmin-5 isoform X1. (386 aa)
CTBP2C-terminal-binding protein 2-like isoform X1. (983 aa)
ADRA2Aalpha-2A adrenergic receptor. (462 aa)
LOC103083735E3 ubiquitin-protein ligase parkin-like. (141 aa)
CLN8Protein CLN8. (302 aa)
GIPC1PDZ domain-containing protein GIPC1 isoform X1. (333 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
SLC1A7Amino acid transporter. (574 aa)
SLC18A1Chromaffin granule amine transporter. (523 aa)
ABAT4-aminobutyrate aminotransferase, mitochondrial; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (500 aa)
LOC103088976Ras-related protein Rap-1b-like isoform X1. (165 aa)
PFN2Profilin; Belongs to the profilin family. (143 aa)
MCTP1Multiple C2 and transmembrane domain-containing protein 1 isoform X1. (999 aa)
LIN7BProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (207 aa)
UNC13CProtein unc-13 homolog C. (1426 aa)
STXBP2Syntaxin-binding protein 2 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (606 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
VPS18Vacuolar protein sorting-associated protein 18 homolog. (973 aa)
UNC13AProtein unc-13 homolog A. (1843 aa)
SYT9Synaptotagmin-9. (589 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
COMTCatechol O-methyltransferase; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. (271 aa)
ATP1A2Sodium/potassium-transporting ATPase subunit alpha. (1020 aa)
LOC103078014Protein unc-13 homolog C-like. (782 aa)
RAB3BRas-related protein Rab-3B. (219 aa)
SLC6A2Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
LOC103080275Cytosolic carboxypeptidase 6-like. (374 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
LIN7CProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (197 aa)
SLC29A2Equilibrative nucleoside transporter 2. (456 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
DAGLASn1-specific diacylglycerol lipase alpha. (1040 aa)
SLC22A1Solute carrier family 22 member 1. (568 aa)
PREPLProlyl endopeptidase-like isoform X1. (727 aa)
GIPC3PDZ domain-containing protein GIPC3. (318 aa)
LRRC1Leucine-rich repeat-containing protein 1. (524 aa)
LOC103077822Profilin; Belongs to the profilin family. (127 aa)
GIPC2PDZ domain-containing protein GIPC2. (311 aa)
RAB3ARas-related protein Rab-3A. (220 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
DTNBP1Dysbindin. (341 aa)
KCNJ10ATP-sensitive inward rectifier potassium channel 10. (379 aa)
TOR1ALOW QUALITY PROTEIN: torsin-1A. (419 aa)
LOC103070824Leucine-rich repeat serine/threonine-protein kinase 2-like. (1609 aa)
SYN1Synapsin-1 isoform X1. (706 aa)
PNKDProbable hydrolase PNKD isoform X1. (383 aa)
SYN2Synapsin-2. (582 aa)
DBHDopamine beta-hydroxylase. (608 aa)
BAIAP3BAI1-associated protein 3 isoform X1. (1152 aa)
SLC4A8Anion exchange protein. (1092 aa)
HNMTHistamine N-methyltransferase. (292 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
LOC103073665Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (534 aa)
NT5DC25'-nucleotidase domain-containing protein 2 isoform X1. (486 aa)
STX1Bsyntaxin-1B isoform X2; Belongs to the syntaxin family. (291 aa)
PRRT2LOW QUALITY PROTEIN: proline-rich transmembrane protein 2. (411 aa)
ALDH5A1Succinate-semialdehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (526 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
ACTN1Alpha-actinin-1 isoform X1. (914 aa)
DOC2ADouble C2-like domain-containing protein alpha isoform X1. (428 aa)
CADPSCalcium-dependent secretion activator 1 isoform X6. (1348 aa)
STX4Syntaxin-4; Belongs to the syntaxin family. (297 aa)
CLN3Battenin. (444 aa)
STXBP5LOW QUALITY PROTEIN: syntaxin-binding protein 5. (1154 aa)
PARK7Protein DJ-1. (189 aa)
RIMS3Regulating synaptic membrane exocytosis protein 3. (308 aa)
UNC13BProtein unc-13 homolog B isoform X1. (1609 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
RPH3ALRab effector Noc2. (289 aa)
NT5DC35'-nucleotidase domain-containing protein 3. (549 aa)
MOXD1DBH-like monooxygenase protein 1. (612 aa)
STX2Syntaxin-2; Belongs to the syntaxin family. (259 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
CASKPeripheral plasma membrane protein CASK isoform X2; Belongs to the MAGUK family. (926 aa)
MAOBAmine oxidase. (520 aa)
STX3Syntaxin-3; Belongs to the syntaxin family. (289 aa)
SLC22A2Solute carrier family 22 member 2. (554 aa)
SLC22A3Solute carrier family 22 member 3. (545 aa)
LIN7AProtein lin-7 homolog; Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells; Belongs to the lin-7 family. (233 aa)
SYT2Synaptotagmin-2 isoform X1. (422 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
VAMP2Vesicle-associated membrane protein 2. (116 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
SLC29A1Equilibrative nucleoside transporter 1. (456 aa)
MAOAAmine oxidase. (527 aa)
RIMS1Regulating synaptic membrane exocytosis protein 1-like isoform X1. (1678 aa)
GPM6BNeuronal membrane glycoprotein M6-b isoform X6. (324 aa)
AGTPBP1Cytosolic carboxypeptidase 1 isoform X1. (1186 aa)
SNAP47LOW QUALITY PROTEIN: synaptosomal-associated protein 47. (491 aa)
SLC5A7High affinity choline transporter 1; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (523 aa)
SLC44A4Choline transporter-like protein 4 isoform X1; Belongs to the CTL (choline transporter-like) family. (706 aa)
PARK2RBR-type E3 ubiquitin transferase. (274 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
SYPSynaptophysin. (313 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
LOC103079561LOW QUALITY PROTEIN: double C2-like domain-containing protein gamma-like. (425 aa)
DAGLBSn1-specific diacylglycerol lipase beta isoform X1. (669 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
ERC2ERC protein 2. (854 aa)
SYN3Synapsin-3 isoform X2. (580 aa)
LOC103071815Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (695 aa)
PPFIA3Liprin-alpha-3. (1194 aa)
HRH3LOW QUALITY PROTEIN: histamine H3 receptor; Belongs to the G-protein coupled receptor 1 family. (387 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (1659 aa)
MCTP2Multiple C2 and transmembrane domain-containing protein 2-like. (861 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
CADPS2Calcium-dependent secretion activator 2. (1190 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
CHRNA5Neuronal acetylcholine receptor subunit alpha-5. (475 aa)
OTOFOtoferlin isoform X1. (1990 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
ASIC1Acid-sensing ion channel 1 isoform X1; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (574 aa)
NF1Neurofibromin isoform X1. (2841 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
CPLX4Complexin-4. (159 aa)
SYT1Synaptotagmin-1 isoform X1. (422 aa)
STX11Syntaxin-11; Belongs to the syntaxin family. (287 aa)
SYT12Synaptotagmin-12 isoform X1. (421 aa)
SNAP29Synaptosomal-associated protein 29. (258 aa)
STXBP5LSyntaxin-binding protein 5-like. (1115 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
SLC6A11Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (638 aa)
NLGN1Neuroligin-1 isoform X1. (863 aa)
LOC103082698Transmembrane O-methyltransferase-like. (258 aa)
FBXL20F-box/LRR-repeat protein 20 isoform X1. (436 aa)
STX19Syntaxin-19. (294 aa)
CPLX2Complexin-2. (134 aa)
THTyrosine 3-monooxygenase. (492 aa)
APBA1Amyloid beta A4 precursor protein-binding family A member 1-like. (843 aa)
RIMS2Regulating synaptic membrane exocytosis protein 2 isoform X1. (1557 aa)
LOC103069601LOW QUALITY PROTEIN: DBH-like monooxygenase protein 2-like. (647 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
SLC17A8Vesicular glutamate transporter 3 isoform X1. (589 aa)
SV2ASynaptic vesicle glycoprotein 2A. (742 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
SYT8Synaptotagmin-8. (360 aa)
STX1Asyntaxin-1A; Belongs to the syntaxin family. (288 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
DGKIDiacylglycerol kinase. (1078 aa)
PDE1BPhosphodiesterase. (535 aa)
SLC18A2Synaptic vesicular amine transporter. (517 aa)
RPH3Arabphilin-3A isoform X1. (703 aa)
LOC103087242Profilin; Belongs to the profilin family. (134 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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