STRINGSTRING
PTGDR PTGDR SH2D1A SH2D1A CD2 CD2 IL4R IL4R IL9R IL9R CSF2RB CSF2RB LOC103089778 LOC103089778 F2 F2 PPP3CB PPP3CB LOC103075361 LOC103075361 MILR1 MILR1 UNC13D UNC13D ANXA3 ANXA3 BCL10 BCL10 LOC103075075 LOC103075075 VAMP2 VAMP2 TREM1 TREM1 EXOSC3 EXOSC3 BTK BTK STAT6 STAT6 NDST2 NDST2 DEF6 DEF6 FCER1G FCER1G ZP3 ZP3 EPHB6 EPHB6 LOC103069236 LOC103069236 CD81 CD81 IRF7 IRF7 CD8A CD8A CPLX2 CPLX2 KIAA1841 KIAA1841 EXOSC6 EXOSC6 LIG4 LIG4 LOC103088397 LOC103088397 S100A13 S100A13 C8B C8B NKG7 NKG7 MASP2 MASP2 TAP2 TAP2 C3 C3 LOC103078393 LOC103078393 MYD88 MYD88 ADORA2B ADORA2B EXO1 EXO1 C8A C8A LOC103088028 LOC103088028 LOC103074903 LOC103074903 ELANE ELANE IRAK4 IRAK4 SNAP23 SNAP23 BATF BATF IL7R IL7R C4A C4A PLEKHM2 PLEKHM2 C9 C9 ERCC1 ERCC1 C2 C2 BCL3 BCL3 LOC103076380 LOC103076380 C1QC C1QC CLEC4G CLEC4G AZU1 AZU1 PTGDS PTGDS RASGRP1 RASGRP1 KIF5B KIF5B STXBP3 STXBP3 TCIRG1 TCIRG1 LOC103084369 LOC103084369 CD74 CD74 UNG UNG BCL6 BCL6 LOC103076960 LOC103076960 LOC103083828 LOC103083828 BCR BCR SCNN1B SCNN1B LOC103079081 LOC103079081 GRP GRP JAG1 JAG1 JAGN1 JAGN1 TRAF3IP2 TRAF3IP2 CORO1A CORO1A IL21R IL21R FOXP3 FOXP3 LYST LYST C1QBP C1QBP DBH DBH PLA2G3 PLA2G3 C5 C5 WDR1 WDR1 TUSC2 TUSC2 AIRE AIRE RABGEF1 RABGEF1 ATAD5 ATAD5 KIT KIT CARD9 CARD9 C1QA C1QA MORN5 MORN5 C7 C7 RAB44 RAB44 RNF8 RNF8 RNF168 RNF168 NLRP6 NLRP6 C1QB C1QB CHGA CHGA PRF1 PRF1 CTSC CTSC CTSH CTSH MSH2 MSH2 CD19 CD19 CD40 CD40 CCR6 CCR6 NBN NBN STAT5B STAT5B SYK SYK LOC103087942 LOC103087942 PRKCD PRKCD MYO1G MYO1G INPP5D INPP5D KMT2E KMT2E TREX1 TREX1 CCL3 CCL3 BTN3A3 BTN3A3 MSH6 MSH6 SWAP70 SWAP70 CD55 CD55 C4BPB C4BPB RFTN1 RFTN1 GZMB GZMB AICDA AICDA PTPN6 PTPN6 C1S C1S LOC103087891 LOC103087891 LAG3 LAG3 C1R C1R MBL2 MBL2 CEBPG CEBPG C6 C6 RNF19B RNF19B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTGDRProstaglandin D2 receptor. (361 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
CD2T-cell surface antigen CD2. (340 aa)
IL4RInterleukin-4 receptor subunit alpha isoform X2. (832 aa)
IL9RInterleukin-9 receptor-like. (606 aa)
CSF2RBCytokine receptor common subunit beta. (896 aa)
LOC103089778Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (350 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
LOC103075361Putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like. (149 aa)
MILR1Allergin-1. (319 aa)
UNC13DProtein unc-13 homolog D. (1090 aa)
ANXA3Annexin. (323 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
LOC103075075Putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8-like. (149 aa)
VAMP2Vesicle-associated membrane protein 2. (116 aa)
TREM1LOW QUALITY PROTEIN: triggering receptor expressed on myeloid cells 1. (254 aa)
EXOSC3Exosome complex component RRP40. (275 aa)
BTKTyrosine-protein kinase. (659 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
NDST2Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2. (883 aa)
DEF6Differentially expressed in FDCP 6 homolog. (631 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (87 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
EPHB6Ephrin type-B receptor 6. (1011 aa)
LOC103069236LOW QUALITY PROTEIN: leukocyte immunoglobulin-like receptor subfamily A member 2-like. (484 aa)
CD81Tetraspanin. (201 aa)
IRF7Interferon regulatory factor 7. (486 aa)
CD8AT-cell surface glycoprotein CD8 alpha chain. (239 aa)
CPLX2Complexin-2. (134 aa)
KIAA1841LOW QUALITY PROTEIN: uncharacterized protein KIAA1841 homolog. (706 aa)
EXOSC6Exosome complex component MTR3. (218 aa)
LIG4DNA ligase. (911 aa)
LOC103088397Vesicle-associated membrane protein 7-like isoform X1; Belongs to the synaptobrevin family. (220 aa)
S100A13Protein S100-A13; Belongs to the S-100 family. (98 aa)
C8BComplement component C8 beta chain. (586 aa)
NKG7Protein NKG7. (165 aa)
MASP2Mannan-binding lectin serine protease 2; Belongs to the peptidase S1 family. (686 aa)
TAP2LOW QUALITY PROTEIN: antigen peptide transporter 2. (746 aa)
C3Complement C3. (1660 aa)
LOC103078393Granzyme M-like; Belongs to the peptidase S1 family. (257 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (296 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
EXO1Exonuclease 1. (835 aa)
C8AComplement component C8 alpha chain. (589 aa)
LOC103088028Granzyme M-like; Belongs to the peptidase S1 family. (167 aa)
LOC103074903Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. (386 aa)
ELANELOW QUALITY PROTEIN: neutrophil elastase; Belongs to the peptidase S1 family. (267 aa)
IRAK4Interleukin-1 receptor-associated kinase 4 isoform X1. (460 aa)
SNAP23Synaptosomal-associated protein; Belongs to the SNAP-25 family. (211 aa)
BATFBasic leucine zipper transcriptional factor ATF-like. (125 aa)
IL7RInterleukin-7 receptor subunit alpha. (459 aa)
C4AComplement C4-A. (1739 aa)
PLEKHM2LOW QUALITY PROTEIN: pleckstrin homology domain-containing family M member 2. (1027 aa)
C9Complement component C9. (548 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (294 aa)
C2Complement C2 isoform X1; Belongs to the peptidase S1 family. (751 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
LOC103076380Complement C3-like. (1659 aa)
C1QCComplement C1q subcomponent subunit C. (245 aa)
CLEC4GC-type lectin domain family 4 member G. (290 aa)
AZU1Azurocidin. (252 aa)
PTGDSprostaglandin-H2 D-isomerase; Belongs to the calycin superfamily. Lipocalin family. (191 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
KIF5BKinesin-1 heavy chain; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1001 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
LOC103084369Histone-lysine N-methyltransferase 2E-like. (243 aa)
CD74HLA class II histocompatibility antigen gamma chain. (278 aa)
UNGUracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. (312 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (728 aa)
LOC103076960Butyrophilin subfamily 3 member A2-like. (144 aa)
LOC103083828E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
BCRBreakpoint cluster region protein isoform X2. (1272 aa)
SCNN1BAmiloride-sensitive sodium channel subunit beta; Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. (641 aa)
LOC103079081Uncharacterized protein LOC103079081. (304 aa)
GRPGastrin-releasing peptide isoform X1. (139 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
JAGN1Protein jagunal homolog 1. (183 aa)
TRAF3IP2Adapter protein CIKS isoform X1. (565 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
IL21RInterleukin-21 receptor. (540 aa)
FOXP3Forkhead box protein P3 isoform X1. (431 aa)
LYSTLysosomal-trafficking regulator isoform X1. (3808 aa)
C1QBPComplement component 1 Q subcomponent-binding protein, mitochondrial. (278 aa)
DBHDopamine beta-hydroxylase. (608 aa)
PLA2G3Group 3 secretory phospholipase A2. (516 aa)
C5LOW QUALITY PROTEIN: complement C5. (1677 aa)
WDR1WD repeat-containing protein 1 isoform X1. (606 aa)
TUSC2Tumor suppressor candidate 2. (110 aa)
AIREAutoimmune regulator. (562 aa)
RABGEF1Rab5 GDP/GTP exchange factor isoform X1. (492 aa)
ATAD5LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5. (1898 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
CARD9Caspase recruitment domain-containing protein 9. (539 aa)
C1QAComplement C1q subcomponent subunit A. (245 aa)
MORN5MORN repeat-containing protein 5. (172 aa)
C7Complement component C7. (843 aa)
RAB44Ras-related protein Rab-44. (931 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
NLRP6LOW QUALITY PROTEIN: NACHT, LRR and PYD domains-containing protein 6. (1030 aa)
C1QBComplement C1q subcomponent subunit B. (252 aa)
CHGAchromogranin-A isoform X2. (446 aa)
PRF1Perforin-1. (555 aa)
CTSCDipeptidyl peptidase 1 isoform X1; Belongs to the peptidase C1 family. (463 aa)
CTSHPro-cathepsin H isoform X1; Belongs to the peptidase C1 family. (335 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
CD19B-lymphocyte antigen CD19. (568 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
CCR6c-C chemokine receptor type 6; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (749 aa)
STAT5BSignal transducer and activator of transcription. (792 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
LOC103087942Signal transducer and activator of transcription 5A-like. (237 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
MYO1GUnconventional myosin-Ig; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1013 aa)
INPP5DPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1. (1187 aa)
KMT2ELOW QUALITY PROTEIN: lysine (K)-specific methyltransferase 2E. (1584 aa)
TREX1LOW QUALITY PROTEIN: three prime repair exonuclease 1. (368 aa)
CCL3LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 3. (88 aa)
BTN3A3Butyrophilin subfamily 3 member A3. (630 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1361 aa)
SWAP70Switch-associated protein 70 isoform X1. (585 aa)
CD55Complement decay-accelerating factor. (571 aa)
C4BPBC4b-binding protein beta chain. (198 aa)
RFTN1Raftlin. (564 aa)
GZMBGranzyme B; Belongs to the peptidase S1 family. (248 aa)
AICDASingle-stranded DNA cytosine deaminase. (208 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
C1SLOW QUALITY PROTEIN: complement C1s subcomponent; Belongs to the peptidase S1 family. (793 aa)
LOC103087891C4b-binding protein alpha chain-like. (665 aa)
LAG3Lymphocyte activation gene 3 protein. (497 aa)
C1RComplement C1r subcomponent; Belongs to the peptidase S1 family. (713 aa)
MBL2LOW QUALITY PROTEIN: mannose-binding protein C. (235 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (149 aa)
C6Complement component C6. (932 aa)
RNF19BRBR-type E3 ubiquitin transferase. (729 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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