STRINGSTRING
MESP1 MESP1 FGF8 FGF8 SPRY1 SPRY1 BMP2 BMP2 FGF2 FGF2 FGF1 FGF1 WNT3A WNT3A WNT2 WNT2 BMP7 BMP7 SULF1 SULF1 AR AR BMP4 BMP4 HOXA11 HOXA11 CITED2 CITED2 FRS2 FRS2 CTNNB1 CTNNB1 FGF10 FGF10 WNT11 WNT11 WNT2B WNT2B GDNF GDNF LOC103079308 LOC103079308 WNT5A WNT5A SHH SHH SIX1 SIX1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MESP1Mesoderm posterior protein 1. (267 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
SULF1Extracellular sulfatase Sulf-1. (1096 aa)
ARAndrogen receptor. (888 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
CITED2Cbp/p300-interacting transactivator 2 isoform X1. (272 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (394 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
LOC103079308Uncharacterized protein LOC103079308. (289 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
SIX1Homeobox protein SIX1. (284 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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