48 items (Lipotes vexillifer) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

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Your Input:
	POLL	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
	ERCC2	TFIIH basal transcription factor complex helicase XPD subunit isoform X1. (760 aa)
	ERCC1	DNA excision repair protein ERCC-1 isoform X1. (294 aa)
	LOC103076106	Non-histone chromosomal protein HMG-14-like. (100 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
	CETN1	Centrin-1. (172 aa)
	SIRT1	LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1. (695 aa)
	GTF2H2	General transcription factor IIH subunit. (395 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2283 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (617 aa)
	FAN1	Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1024 aa)
	DDB2	DNA damage-binding protein 2 isoform X1. (463 aa)
	CETN2	Centrin-2. (204 aa)
	GTF2H5	General transcription factor IIH subunit 5. (71 aa)
	ERCC6	DNA excision repair protein ERCC-6. (1485 aa)
	OGG1	LOW QUALITY PROTEIN: N-glycosylase/DNA lyase. (318 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (304 aa)
	SLX4	LOW QUALITY PROTEIN: structure-specific endonuclease subunit SLX4. (1776 aa)
	ERCC8	DNA excision repair protein ERCC-8 isoform X1. (396 aa)
	GTF2H4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (463 aa)
	RPA3	Replication protein A 14 kDa subunit. (121 aa)
	FANCC	LOW QUALITY PROTEIN: Fanconi anemia group C protein homolog. (639 aa)
	POLD3	DNA polymerase delta subunit 3. (469 aa)
	HUS1	Checkpoint protein; Belongs to the HUS1 family. (280 aa)
	GTF2H3	General transcription factor IIH subunit 3 isoform X1. (309 aa)
	XPC	DNA repair protein complementing XP-C cells. (940 aa)
	POLR2I	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (132 aa)
	USP7	Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family. (1107 aa)
	RAD23A	UV excision repair protein RAD23 homolog A isoform X1. (363 aa)
	UVSSA	UV-stimulated scaffold protein A. (686 aa)
	BRIP1	LOW QUALITY PROTEIN: Fanconi anemia group J protein. (1241 aa)
	GTF2H1	General transcription factor IIH subunit 1. (548 aa)
	POLD1	DNA polymerase. (1107 aa)
	COMMD1	COMM domain-containing protein 1. (188 aa)
	LIG4	DNA ligase. (911 aa)
	BRCA2	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa)
	ERCC5	DNA repair protein complementing XP-G cells. (1201 aa)
	XPA	DNA repair protein complementing XP-A cells. (273 aa)
	KAT5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
	XAB2	pre-mRNA-splicing factor SYF1. (853 aa)
	ERCC4	DNA repair endonuclease XPF. (916 aa)
	LOC103074718	UV excision repair protein RAD23 homolog B-like isoform X1. (408 aa)
	POLK	DNA polymerase kappa. (885 aa)
	BIVM	Basic immunoglobulin-like variable motif-containing protein isoform X1. (504 aa)
	HMGN2	Non-histone chromosomal protein HMG-17. (90 aa)
	ERCC3	TFIIH basal transcription factor complex helicase XPB subunit. (782 aa)
	RPA2	Replication protein A 32 kDa subunit. (270 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIVM	BRCA2	A0A340XJJ3	A0A340XSP0	Basic immunoglobulin-like variable motif-containing protein isoform X1.	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	0.774
BIVM	BRIP1	A0A340XJJ3	A0A340Y076	Basic immunoglobulin-like variable motif-containing protein isoform X1.	LOW QUALITY PROTEIN: Fanconi anemia group J protein.	0.505
BIVM	CETN1	A0A340XJJ3	A0A340XCG3	Basic immunoglobulin-like variable motif-containing protein isoform X1.	Centrin-1.	0.413
BIVM	CETN2	A0A340XJJ3	A0A340X073	Basic immunoglobulin-like variable motif-containing protein isoform X1.	Centrin-2.	0.641
BIVM	DDB2	A0A340XJJ3	A0A340X3C0	Basic immunoglobulin-like variable motif-containing protein isoform X1.	DNA damage-binding protein 2 isoform X1.	0.597
BIVM	ERCC1	A0A340XJJ3	A0A340XHT3	Basic immunoglobulin-like variable motif-containing protein isoform X1.	DNA excision repair protein ERCC-1 isoform X1.	0.752
BIVM	ERCC2	A0A340XJJ3	A0A340XHU0	Basic immunoglobulin-like variable motif-containing protein isoform X1.	TFIIH basal transcription factor complex helicase XPD subunit isoform X1.	0.917
BIVM	ERCC3	A0A340XJJ3	A0A340XIX1	Basic immunoglobulin-like variable motif-containing protein isoform X1.	TFIIH basal transcription factor complex helicase XPB subunit.	0.919
BIVM	ERCC4	A0A340XJJ3	A0A340XN74	Basic immunoglobulin-like variable motif-containing protein isoform X1.	DNA repair endonuclease XPF.	0.815
BIVM	ERCC5	A0A340XJJ3	A0A340XRA5	Basic immunoglobulin-like variable motif-containing protein isoform X1.	DNA repair protein complementing XP-G cells.	0.611
BIVM	ERCC6	A0A340XJJ3	A0A340WGY4	Basic immunoglobulin-like variable motif-containing protein isoform X1.	DNA excision repair protein ERCC-6.	0.942
BIVM	ERCC8	A0A340XJJ3	A0A340WUY6	Basic immunoglobulin-like variable motif-containing protein isoform X1.	DNA excision repair protein ERCC-8 isoform X1.	0.439
BIVM	GTF2H1	A0A340XJJ3	A0A340Y006	Basic immunoglobulin-like variable motif-containing protein isoform X1.	General transcription factor IIH subunit 1.	0.928
BIVM	GTF2H2	A0A340XJJ3	A0A340X6E1	Basic immunoglobulin-like variable motif-containing protein isoform X1.	General transcription factor IIH subunit.	0.802
BIVM	GTF2H3	A0A340XJJ3	A0A340WJ27	Basic immunoglobulin-like variable motif-containing protein isoform X1.	General transcription factor IIH subunit 3 isoform X1.	0.618
BIVM	GTF2H4	A0A340XJJ3	A0A340WQA5	Basic immunoglobulin-like variable motif-containing protein isoform X1.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.520
BIVM	GTF2H5	A0A340XJJ3	A0A340WX34	Basic immunoglobulin-like variable motif-containing protein isoform X1.	General transcription factor IIH subunit 5.	0.647
BIVM	HMGN2	A0A340XJJ3	A0A340XJI0	Basic immunoglobulin-like variable motif-containing protein isoform X1.	Non-histone chromosomal protein HMG-17.	0.522
BIVM	HUS1	A0A340XJJ3	A0A340WJY1	Basic immunoglobulin-like variable motif-containing protein isoform X1.	Checkpoint protein; Belongs to the HUS1 family.	0.572
BIVM	LIG4	A0A340XJJ3	A0A340XTX4	Basic immunoglobulin-like variable motif-containing protein isoform X1.	DNA ligase.	0.634