STRINGSTRING
ATP2A3 ATP2A3 EDN2 EDN2 LOC103085734 LOC103085734 RMDN2 RMDN2 ATP2B2 ATP2B2 NPTN NPTN LOC103070786 LOC103070786 TRPV4 TRPV4 SLC8A1 SLC8A1 TMEM178A TMEM178A EDN1 EDN1 TRPC6 TRPC6 ATP2A2 ATP2A2 CALB1 CALB1 ATP2B4 ATP2B4 CD40 CD40 LOC103090695 LOC103090695 PML PML SYPL2 SYPL2 TRPC1 TRPC1 EDN3 EDN3 LOC103076060 LOC103076060 LOC103075777 LOC103075777 TRPC4 TRPC4 SLC24A1 SLC24A1 TGM2 TGM2 MYH7B MYH7B TCIRG1 TCIRG1 ANXA6 ANXA6 ADCY8 ADCY8 PRKCB PRKCB HTR2C HTR2C STIM2 STIM2 ATP2B1 ATP2B1 VAPB VAPB PKHD1 PKHD1 TMEM165 TMEM165 PKD2 PKD2 GRM1 GRM1 CASR CASR ATP13A3 ATP13A3 SLC30A1 SLC30A1 LOC103089341 LOC103089341 CAV1 CAV1 RYR2 RYR2 ATF4 ATF4 PACS2 PACS2 ATP2A1 ATP2A1 SLC24A4 SLC24A4 SLC24A3 SLC24A3 PLN PLN MCU MCU CDH23 CDH23 ATP2C2 ATP2C2 CLN3 CLN3 ITPR1 ITPR1 F2 F2 MICU1 MICU1 KCTD17 KCTD17 SMDT1 SMDT1 SLC37A4 SLC37A4 ATP2B3 ATP2B3 CASQ2 CASQ2 FKBP1B FKBP1B DRD3 DRD3 CDH5 CDH5 LOC103080131 LOC103080131 ATP13A4 ATP13A4 SLC24A5 SLC24A5 DHRS7C DHRS7C WNT5A WNT5A STOML2 STOML2 SLC8A2 SLC8A2 BBC3 BBC3 DMPK DMPK TMEM64 TMEM64 STC1 STC1 TMEM203 TMEM203 CSRP3 CSRP3 BCAP31 BCAP31 CCDC47 CCDC47 MICU3 MICU3 LOC103090842 LOC103090842 GRIA1 GRIA1 ATP1B1 ATP1B1 LOC103075456 LOC103075456 SLC25A23 SLC25A23 TGFB1 TGFB1 PSEN1 PSEN1 ATP13A2 ATP13A2 TMTC4 TMTC4 GRM5 GRM5 LOC103084703 LOC103084703 RMDN3 RMDN3 ATP2C1 ATP2C1 HTR2B HTR2B LOC103069848 LOC103069848 CALB2 CALB2 CHERP CHERP STIM1 STIM1 CCDC109B CCDC109B HRC HRC TRPC7 TRPC7 ATP13A1 ATP13A1 SV2A SV2A MCUR1 MCUR1 WFS1 WFS1 LOC103077570 LOC103077570 MICU2 MICU2 BCL2 BCL2 GRINA GRINA CAV3 CAV3 VDR VDR TRPC3 TRPC3 GRIK2 GRIK2 HTR2A HTR2A APP APP GPER1 GPER1 LETM1 LETM1 IMMT IMMT TPCN2 TPCN2 GCM2 GCM2 HERPUD1 HERPUD1 KEL KEL LOC103090362 LOC103090362 UMOD UMOD TNNI3 TNNI3 LOC103091617 LOC103091617 SLC24A2 SLC24A2 SLC8B1 SLC8B1 HCRTR1 HCRTR1 LOC103072458 LOC103072458 RYR1 RYR1 FIS1 FIS1 SCGN SCGN PTH1R PTH1R ATP7B ATP7B EDNRA EDNRA BOK BOK SLC35G1 SLC35G1 HCRTR2 HCRTR2 GPR12 GPR12 PDZD8 PDZD8 SLC10A7 SLC10A7 LOC103077895 LOC103077895 CCL3 CCL3 PTH PTH
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
EDN2Endothelin-2. (180 aa)
LOC103085734Thyroid adenoma-associated protein homolog. (610 aa)
RMDN2Regulator of microtubule dynamics protein 2. (493 aa)
ATP2B2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1243 aa)
NPTNNeuroplastin isoform X1. (398 aa)
LOC103070786Thyroid adenoma-associated protein homolog. (1075 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (863 aa)
SLC8A1Sodium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (970 aa)
TMEM178ATransmembrane protein 178A. (115 aa)
EDN1Endothelin-1. (202 aa)
TRPC6Short transient receptor potential channel 6 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (932 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1039 aa)
CALB1LOW QUALITY PROTEIN: calbindin. (263 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
LOC103090695Transmembrane protein 203-like. (228 aa)
PMLProtein PML. (848 aa)
SYPL2Synaptophysin-like protein 2. (264 aa)
TRPC1Short transient receptor potential channel 1; Belongs to the transient receptor (TC 1.A.4) family. (794 aa)
EDN3Endothelin-3. (211 aa)
LOC103076060LOW QUALITY PROTEIN: calcitonin receptor-stimulating peptide 2-like. (202 aa)
LOC103075777LOW QUALITY PROTEIN: selenoprotein K-like. (94 aa)
TRPC4Short transient receptor potential channel 4 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (982 aa)
SLC24A1Sodium/potassium/calcium exchanger 1 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (1066 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2 isoform X1. (687 aa)
MYH7BLOW QUALITY PROTEIN: myosin-7B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1852 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
ANXA6Annexin. (672 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
HTR2C5-hydroxytryptamine receptor 2C. (458 aa)
STIM2Stromal interaction molecule 2 isoform X1. (838 aa)
ATP2B1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1220 aa)
VAPBVesicle-associated membrane protein-associated protein B. (243 aa)
PKHD1Fibrocystin. (4074 aa)
TMEM165GDT1 family protein. (324 aa)
PKD2LOW QUALITY PROTEIN: polycystin-2. (963 aa)
GRM1Metabotropic glutamate receptor 1 isoform X1. (1194 aa)
CASRExtracellular calcium-sensing receptor isoform X1. (1091 aa)
ATP13A3Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1229 aa)
SLC30A1Zinc transporter 1. (504 aa)
LOC103089341Essential MCU regulator, mitochondrial-like. (84 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
RYR2Ryanodine receptor 2-like. (4986 aa)
ATF4Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
PACS2Phosphofurin acidic cluster sorting protein 2 isoform X2. (906 aa)
ATP2A1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1000 aa)
SLC24A4Sodium/potassium/calcium exchanger 4 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (618 aa)
SLC24A3Sodium/potassium/calcium exchanger 3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (642 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
MCUCalcium uniporter protein, mitochondrial. (348 aa)
CDH23Cadherin-23 isoform X1. (3354 aa)
ATP2C2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (946 aa)
CLN3Battenin. (444 aa)
ITPR1Inositol 1,4,5-trisphosphate receptor type 1 isoform X1. (2744 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (623 aa)
MICU1Calcium uptake protein 1, mitochondrial isoform X1. (480 aa)
KCTD17BTB/POZ domain-containing protein KCTD17 isoform X1. (314 aa)
SMDT1Essential MCU regulator, mitochondrial. (107 aa)
SLC37A4Glucose-6-phosphate translocase isoform X1. (450 aa)
ATP2B3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1218 aa)
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (410 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. (782 aa)
LOC103080131Calcium load-activated calcium channel; Calcium-selective channel required to prevent calcium stores from overfilling; Belongs to the TMCO1 family. (188 aa)
ATP13A4Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1197 aa)
SLC24A5Sodium/potassium/calcium exchanger 5 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (501 aa)
DHRS7CDehydrogenase/reductase SDR family member 7C isoform X1; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (312 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
STOML2Stomatin-like protein 2, mitochondrial isoform X1. (356 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
BBC3Bcl-2-binding component 3. (193 aa)
DMPKMyotonin-protein kinase isoform X1. (630 aa)
TMEM64Transmembrane protein 64 isoform X1. (383 aa)
STC1Stanniocalcin-1. (247 aa)
TMEM203Transmembrane protein 203. (136 aa)
CSRP3Cysteine and glycine-rich protein 3. (194 aa)
BCAP31B-cell receptor-associated protein 31. (246 aa)
CCDC47Coiled-coil domain-containing protein 47 isoform X1. (483 aa)
MICU3Calcium uptake protein 3, mitochondrial. (532 aa)
LOC103090842Calcitonin receptor-stimulating peptide 3-like. (125 aa)
GRIA1Glutamate receptor 1 isoform X1. (906 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
LOC103075456c-C motif chemokine 8-like. (99 aa)
SLC25A23Calcium-binding mitochondrial carrier protein SCaMC-3; Belongs to the mitochondrial carrier (TC 2.A.29) family. (468 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1174 aa)
TMTC4Transmembrane and TPR repeat-containing protein 4 isoform X1. (775 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1204 aa)
LOC103084703Neuronal acetylcholine receptor subunit alpha-7-like. (499 aa)
RMDN3Regulator of microtubule dynamics protein 3. (466 aa)
ATP2C1Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (953 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
LOC103069848Putative Bcl-2 homologous antagonist/killer 2-like. (211 aa)
CALB2Calretinin isoform X1. (272 aa)
CHERPCalcium homeostasis endoplasmic reticulum protein. (913 aa)
STIM1Stromal interaction molecule 1 isoform X1. (785 aa)
CCDC109BLOW QUALITY PROTEIN: mitochondrial calcium uniporter regulatory subunit MCUb. (334 aa)
HRCSarcoplasmic reticulum histidine-rich calcium-binding protein. (628 aa)
TRPC7Short transient receptor potential channel 7 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (862 aa)
ATP13A1Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1206 aa)
SV2ASynaptic vesicle glycoprotein 2A. (742 aa)
MCUR1Mitochondrial calcium uniporter regulator 1. (361 aa)
WFS1Wolframin. (889 aa)
LOC103077570Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (369 aa)
MICU2Calcium uptake protein 2, mitochondrial. (376 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
GRINAProtein lifeguard 1. (366 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
VDRVitamin D3 receptor isoform X1. (427 aa)
TRPC3Short transient receptor potential channel 3 isoform X1; Belongs to the transient receptor (TC 1.A.4) family. (920 aa)
GRIK2Glutamate receptor ionotropic, kainate 2-like isoform X1. (908 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
APPAmyloid beta A4 protein isoform X1. (767 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
LETM1LETM1 and EF-hand domain-containing protein 1, mitochondrial. (908 aa)
IMMTMICOS complex subunit MIC60; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. (758 aa)
TPCN2Two pore calcium channel protein 2. (758 aa)
GCM2Chorion-specific transcription factor GCMb. (505 aa)
HERPUD1Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein. (363 aa)
KELKell blood group glycoprotein. (720 aa)
LOC103090362Vomeronasal type-2 receptor 116-like. (285 aa)
UMODUromodulin. (643 aa)
TNNI3Troponin I, cardiac muscle. (211 aa)
LOC103091617Protein C19orf12 homolog. (178 aa)
SLC24A2Sodium/potassium/calcium exchanger 2 isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (662 aa)
SLC8B1Sodium/potassium/calcium exchanger 6, mitochondrial isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (600 aa)
HCRTR1Orexin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
LOC103072458Uncharacterized protein C2orf47 homolog, mitochondrial. (291 aa)
RYR1Ryanodine receptor 1 isoform X2. (5032 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
SCGNSecretagogin. (276 aa)
PTH1RParathyroid hormone/parathyroid hormone-related peptide receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (591 aa)
ATP7BCopper-transporting ATPase 2. (1614 aa)
EDNRAEndothelin-1 receptor isoform X2. (318 aa)
BOKBcl-2-related ovarian killer protein. (213 aa)
SLC35G1Solute carrier family 35 member G1 isoform X1. (365 aa)
HCRTR2Orexin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (386 aa)
GPR12G-protein coupled receptor 12; Belongs to the G-protein coupled receptor 1 family. (334 aa)
PDZD8LOW QUALITY PROTEIN: PDZ domain containing 8. (1153 aa)
SLC10A7Sodium/bile acid cotransporter; Does not show transport activity towards bile acids or steroid sulfates; Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. (340 aa)
LOC103077895Protein C19orf12 homolog. (141 aa)
CCL3LOW QUALITY PROTEIN: chemokine (C-C motif) ligand 3. (88 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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