STRINGSTRING
MPDZ MPDZ TOP2B TOP2B CITED1 CITED1 PHB PHB SNF8 SNF8 IFT52 IFT52 CTNNB1 CTNNB1 PTK2B PTK2B CNRIP1 CNRIP1 SNTG1 SNTG1 VPS4B VPS4B SDC1 SDC1 CAV3 CAV3 YEATS4 YEATS4 ECM1 ECM1 ITGB3BP ITGB3BP SDCBP2 SDCBP2 TOP2A TOP2A ERBB2 ERBB2 XRCC5 XRCC5 MAD2L1 MAD2L1 LIG4 LIG4 AGO2 AGO2 PLEKHB2 PLEKHB2 BRCA2 BRCA2 INADL INADL PEX1 PEX1 EPB41 EPB41 EZR EZR PPP2CA PPP2CA NUMA1 NUMA1 ERCC4 ERCC4 RAD51 RAD51 DAB2 DAB2 ERCC3 ERCC3 ATXN1 ATXN1 HOMER3 HOMER3 TCF4 TCF4 ERCC2 ERCC2 ERCC1 ERCC1 PCGF1 PCGF1 HSPG2 HSPG2 PEX6 PEX6 ATP1B1 ATP1B1 MSH2 MSH2 DLG4 DLG4 SAE1 SAE1 PAXIP1 PAXIP1 LOC103079687 LOC103079687 PIAS3 PIAS3 SCLT1 SCLT1 CACNA1B CACNA1B SIRT1 SIRT1 FN1 FN1 NEFL NEFL PDZD3 PDZD3 BCAM BCAM PEX16 PEX16 BCL10 BCL10 VGLL2 VGLL2 CDK7 CDK7 CEP120 CEP120 MCAM MCAM IFT46 IFT46 CTGF CTGF FBLN5 FBLN5 TESK1 TESK1 AXIN1 AXIN1 TAX1BP3 TAX1BP3 MIF4GD MIF4GD TNFAIP3 TNFAIP3 EP300 EP300 XRCC6 XRCC6 MYO1C MYO1C LOC103074970 LOC103074970 SREBF2 SREBF2 PICK1 PICK1 XRCC4 XRCC4 FBLN1 FBLN1 CENPF CENPF SASH1 SASH1 SLC9A3R2 SLC9A3R2 ABL1 ABL1 HIC2 HIC2 PCNA PCNA CORO1A CORO1A NCF2 NCF2 LOC103069148 LOC103069148 MID1IP1 MID1IP1 HESX1 HESX1 MRE11A MRE11A CEP135 CEP135 TERF2 TERF2 MDC1 MDC1 GPSM2 GPSM2 MKI67 MKI67 VTA1 VTA1 LOC103084372 LOC103084372 MAP2K1 MAP2K1 NIPBL NIPBL VPS4A VPS4A GRIP1 GRIP1 ARL6IP5 ARL6IP5 LOC103087231 LOC103087231 YAP1 YAP1 PRRC2C PRRC2C LOC103076219 LOC103076219 PLEKHB1 PLEKHB1 ERCC6 ERCC6 CEP250 CEP250 TNNI3K TNNI3K NPAT NPAT SRC SRC NEIL1 NEIL1 LOC103070587 LOC103070587 LOC103069036 LOC103069036 PXK PXK VPS36 VPS36 DNM1 DNM1 FOXN3 FOXN3 MAPRE3 MAPRE3 TERT TERT USP7 USP7 SYNJ2BP SYNJ2BP PRDX3 PRDX3 LCK LCK MED12 MED12 PEX5 PEX5 PDZD11 PDZD11 PEX26 PEX26 RBFOX1 RBFOX1 PHB2 PHB2 VGLL3 VGLL3 LOC103074383 LOC103074383 KPNA3 KPNA3 HRAS HRAS DLG1 DLG1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MPDZLOW QUALITY PROTEIN: multiple PDZ domain protein. (2038 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1615 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (221 aa)
PHBProhibitin. (297 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
IFT52Intraflagellar transport protein 52 homolog isoform X1. (446 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
CNRIP1CB1 cannabinoid receptor-interacting protein 1. (164 aa)
SNTG1Gamma-1-syntrophin. (517 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (443 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
YEATS4YEATS domain-containing protein 4. (227 aa)
ECM1Extracellular matrix protein 1 isoform X1. (578 aa)
ITGB3BPCentromere protein R. (242 aa)
SDCBP2Syntenin-2. (313 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1533 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
MAD2L1Mitotic spindle assembly checkpoint protein MAD2A. (205 aa)
LIG4DNA ligase. (911 aa)
AGO2LOW QUALITY PROTEIN: protein argonaute-2; Belongs to the argonaute family. (785 aa)
PLEKHB2Pleckstrin homology domain-containing family B member 2 isoform X1. (230 aa)
BRCA2LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa)
INADLinaD-like protein. (1878 aa)
PEX1Peroxisome biogenesis factor 1. (1294 aa)
EPB41Protein 4.1 isoform X1. (864 aa)
EZREzrin isoform X1. (586 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
NUMA1Nuclear mitotic apparatus protein 1. (2140 aa)
ERCC4DNA repair endonuclease XPF. (916 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
DAB2Disabled homolog 2. (769 aa)
ERCC3TFIIH basal transcription factor complex helicase XPB subunit. (782 aa)
ATXN1Ataxin-1. (807 aa)
HOMER3Homer protein homolog 3 isoform X1. (360 aa)
TCF4Transcription factor 4 isoform X10. (592 aa)
ERCC2TFIIH basal transcription factor complex helicase XPD subunit isoform X1. (760 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X1. (294 aa)
PCGF1Polycomb group RING finger protein 1. (259 aa)
HSPG2Basement membrane-specific heparan sulfate proteoglycan core protein. (4406 aa)
PEX6Peroxisome assembly factor 2 isoform X1. (980 aa)
ATP1B1Sodium/potassium-transporting ATPase subunit beta; This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. Belongs to the X(+)/potassium ATPases subunit beta family. (303 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
DLG4Disks large homolog 4 isoform X1; Belongs to the MAGUK family. (754 aa)
SAE1SUMO-activating enzyme subunit 1 isoform X1. (346 aa)
PAXIP1PAX-interacting protein 1. (964 aa)
LOC103079687Peroxiredoxin-like. (187 aa)
PIAS3E3 SUMO-protein ligase PIAS3. (628 aa)
SCLT1Sodium channel and clathrin linker 1. (665 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2261 aa)
SIRT1LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1. (695 aa)
FN1LOW QUALITY PROTEIN: fibronectin. (2483 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (552 aa)
PDZD3Na(+)/H(+) exchange regulatory cofactor NHE-RF4 isoform X1. (502 aa)
BCAMBasal cell adhesion molecule. (628 aa)
PEX16Peroxisomal membrane protein PEX16. (335 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
VGLL2Transcription cofactor vestigial-like protein 2 isoform X1. (339 aa)
CDK7Cyclin-dependent kinase 7 isoform X1; Belongs to the protein kinase superfamily. (353 aa)
CEP120Centrosomal protein of 120 kDa isoform X1. (987 aa)
MCAMCell surface glycoprotein MUC18. (670 aa)
IFT46LOW QUALITY PROTEIN: intraflagellar transport protein 46 homolog. (353 aa)
CTGFConnective tissue growth factor. (349 aa)
FBLN5Fibulin-5. (448 aa)
TESK1Dual specificity testis-specific protein kinase 1. (628 aa)
AXIN1Axin-1. (866 aa)
TAX1BP3Tax1-binding protein 3; May regulate a number of protein-protein interactions by competing for PDZ domain binding sites. (124 aa)
MIF4GDMIF4G domain-containing protein. (224 aa)
TNFAIP3Tumor necrosis factor alpha-induced protein 3. (785 aa)
EP300Histone acetyltransferase p300. (2420 aa)
XRCC6X-ray repair cross-complementing protein 6 isoform X1. (609 aa)
MYO1CUnconventional myosin-Ic isoform X1; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1063 aa)
LOC103074970Probable DNA gyrase subunit A, chloroplastic/mitochondrial-like. (985 aa)
SREBF2Sterol regulatory element-binding protein 2. (1297 aa)
PICK1PRKCA-binding protein isoform X1. (417 aa)
XRCC4DNA repair protein XRCC4. (333 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (706 aa)
CENPFCentromere protein F. (3071 aa)
SASH1SAM and SH3 domain-containing protein 1. (1235 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (337 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
HIC2Hypermethylated in cancer 2 protein-like. (613 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
NCF2Neutrophil cytosol factor 2 isoform X1. (526 aa)
LOC103069148Fidgetin-like; Belongs to the AAA ATPase family. (748 aa)
MID1IP1Mid1-interacting protein 1. (183 aa)
HESX1Homeobox expressed in ES cells 1. (186 aa)
MRE11ADouble-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (707 aa)
CEP135Centrosomal protein of 135 kDa. (1148 aa)
TERF2Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (539 aa)
MDC1Mediator of DNA damage checkpoint protein 1. (2091 aa)
GPSM2LOW QUALITY PROTEIN: G-protein-signaling modulator 2. (684 aa)
MKI67Antigen KI-67. (2385 aa)
VTA1Vacuolar protein sorting-associated protein VTA1 homolog isoform X1. (309 aa)
LOC103084372DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (634 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
NIPBLNipped-B protein. (2803 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (437 aa)
GRIP1Glutamate receptor-interacting protein 1. (1022 aa)
ARL6IP5PRA1 family protein. (188 aa)
LOC103087231Yorkie homolog isoform X1. (489 aa)
YAP1Yorkie homolog. (430 aa)
PRRC2CProtein PRRC2C isoform X1. (2784 aa)
LOC103076219DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
PLEKHB1Pleckstrin homology domain-containing family B member 1 isoform X1. (243 aa)
ERCC6DNA excision repair protein ERCC-6. (1485 aa)
CEP250Centrosome-associated protein CEP250. (2447 aa)
TNNI3KSerine/threonine-protein kinase TNNI3K. (654 aa)
NPATProtein NPAT. (1436 aa)
SRCTyrosine-protein kinase. (548 aa)
NEIL1Endonuclease 8-like 1. (390 aa)
LOC103070587Tyrosine-protein kinase ABL1-like. (126 aa)
LOC103069036Peroxisome assembly protein 12; Required for protein import into peroxisomes. Belongs to the pex2/pex10/pex12 family. (359 aa)
PXKLOW QUALITY PROTEIN: PX domain containing serine/threonine kinase. (586 aa)
VPS36Vacuolar protein-sorting-associated protein 36 isoform X1. (386 aa)
DNM1Dynamin-1 isoform X3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
FOXN3Forkhead box protein N3 isoform X1. (488 aa)
MAPRE3Microtubule-associated protein RP/EB family member 3 isoform X1. (301 aa)
TERTTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nuc [...] (1127 aa)
USP7Ubiquitin carboxyl-terminal hydrolase 7 isoform X1; Belongs to the peptidase C19 family. (1107 aa)
SYNJ2BPSynaptojanin-2-binding protein. (145 aa)
PRDX3Thioredoxin-dependent peroxide reductase, mitochondrial isoform X1. (257 aa)
LCKTyrosine-protein kinase. (520 aa)
MED12Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2185 aa)
PEX5Peroxisomal targeting signal 1 receptor isoform X1. (656 aa)
PDZD11PDZ domain-containing protein 11. (174 aa)
PEX26Peroxisome assembly protein 26. (300 aa)
RBFOX1RNA binding protein fox-1 homolog; RNA-binding protein that regulates alternative splicing events. (399 aa)
PHB2Prohibitin. (299 aa)
VGLL3Transcription cofactor vestigial-like protein 3 isoform X1. (329 aa)
LOC103074383DNA topoisomerase 2-beta-like. (371 aa)
KPNA3Importin subunit alpha-4. (704 aa)
HRASGTPase HRas isoform X1. (189 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (16%) [HD]