(29 nodes) Motor neuron axon guidance network (Lipotes vexillifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HOXA2	Homeobox protein Hox-A2. (372 aa)
	LHX4	LIM/homeobox protein Lhx4. (389 aa)
	EGR2	E3 SUMO-protein ligase EGR2 isoform X1. (485 aa)
	LAMC2	Laminin subunit gamma-2. (1191 aa)
	CHN1	Chimaerin; GTPase-activating protein for p21-rac. (459 aa)
	RHOH	Rho-related GTP-binding protein RhoH. (191 aa)
	NTN3	Netrin-3. (580 aa)
	RAC2	Ras-related C3 botulinum toxin substrate 2. (192 aa)
	KIF5C	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (955 aa)
	PLXNA4	plexin-A4 isoform X3. (1903 aa)
	SLIT1	Slit homolog 1 protein. (1534 aa)
	PLXNA3	plexin-A3. (1873 aa)
	NTN1	Netrin-1 isoform X1. (604 aa)
	LHX3	LIM/homeobox protein Lhx3 isoform X1. (403 aa)
	RAC3	Ras-related C3 botulinum toxin substrate 3. (192 aa)
	SEMA3A	semaphorin-3A; Belongs to the semaphorin family. (772 aa)
	LHX1	LIM/homeobox protein Lhx1. (406 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1255 aa)
	RHOG	Rho-related GTP-binding protein RhoG. (191 aa)
	NTN5	Netrin-5. (489 aa)
	SLIT2	LOW QUALITY PROTEIN: slit homolog 2 protein. (1521 aa)
	RNF165	RING finger protein 165. (347 aa)
	MYCBP2	Probable E3 ubiquitin-protein ligase MYCBP2. (4693 aa)
	EPHA4	Ephrin type-A receptor 4-like isoform X1. (986 aa)
	SEMA3F	semaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
	LOC103074825	CD166 antigen-like isoform X1. (583 aa)
	CDK5	Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
	LOC103083466	Rho-related GTP-binding protein RhoG-like. (191 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK5	PLXNA3	A0A340Y9Y7	A0A340XE65	Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily.	plexin-A3.	0.571
CDK5	PLXNA4	A0A340Y9Y7	A0A340X858	Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily.	plexin-A4 isoform X3.	0.569
CDK5	SEMA3A	A0A340Y9Y7	A0A340XUH2	Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily.	semaphorin-3A; Belongs to the semaphorin family.	0.689
CHN1	EPHA4	A0A340WVM1	A0A340Y2C3	Chimaerin; GTPase-activating protein for p21-rac.	Ephrin type-A receptor 4-like isoform X1.	0.510
EGR2	HOXA2	A0A340WH76	A0A340XYA9	E3 SUMO-protein ligase EGR2 isoform X1.	Homeobox protein Hox-A2.	0.411
EPHA4	CHN1	A0A340Y2C3	A0A340WVM1	Ephrin type-A receptor 4-like isoform X1.	Chimaerin; GTPase-activating protein for p21-rac.	0.510
EPHA4	SEMA3A	A0A340Y2C3	A0A340XUH2	Ephrin type-A receptor 4-like isoform X1.	semaphorin-3A; Belongs to the semaphorin family.	0.560
ERBB2	LOC103083466	A0A340XV51	A0A340YFD7	Receptor protein-tyrosine kinase.	Rho-related GTP-binding protein RhoG-like.	0.413
ERBB2	RHOG	A0A340XV51	A0A340XVD8	Receptor protein-tyrosine kinase.	Rho-related GTP-binding protein RhoG.	0.413
HOXA2	EGR2	A0A340XYA9	A0A340WH76	Homeobox protein Hox-A2.	E3 SUMO-protein ligase EGR2 isoform X1.	0.411
LOC103083466	ERBB2	A0A340YFD7	A0A340XV51	Rho-related GTP-binding protein RhoG-like.	Receptor protein-tyrosine kinase.	0.413
LOC103083466	RAC2	A0A340YFD7	A0A340X4C7	Rho-related GTP-binding protein RhoG-like.	Ras-related C3 botulinum toxin substrate 2.	0.504
LOC103083466	RAC3	A0A340YFD7	A0A340XTF2	Rho-related GTP-binding protein RhoG-like.	Ras-related C3 botulinum toxin substrate 3.	0.431
LOC103083466	RHOG	A0A340YFD7	A0A340XVD8	Rho-related GTP-binding protein RhoG-like.	Rho-related GTP-binding protein RhoG.	0.901
NTN1	SEMA3A	A0A340XFU1	A0A340XUH2	Netrin-1 isoform X1.	semaphorin-3A; Belongs to the semaphorin family.	0.640
NTN1	SEMA3F	A0A340XFU1	A0A340Y3S7	Netrin-1 isoform X1.	semaphorin-3F isoform X1; Belongs to the semaphorin family.	0.418
NTN1	SLIT1	A0A340XFU1	A0A340XAR7	Netrin-1 isoform X1.	Slit homolog 1 protein.	0.774
NTN1	SLIT2	A0A340XFU1	A0A340XZB8	Netrin-1 isoform X1.	LOW QUALITY PROTEIN: slit homolog 2 protein.	0.564
NTN5	SLIT1	A0A340XVK2	A0A340XAR7	Netrin-5.	Slit homolog 1 protein.	0.447
PLXNA3	CDK5	A0A340XE65	A0A340Y9Y7	plexin-A3.	Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily.	0.571