STRINGSTRING
GDF6 GDF6 LEFTY2 LEFTY2 TGFA TGFA FGF7 FGF7 GDF2 GDF2 IL12A IL12A GDF10 GDF10 LOC103089261 LOC103089261 BMP8B BMP8B JAG2 JAG2 PDGFB PDGFB LOC103077537 LOC103077537 LOC103073398 LOC103073398 NODAL NODAL NGF NGF GDNF GDNF LOC103081170 LOC103081170 GKN1 GKN1 FIGF FIGF BMP6 BMP6 IL12B IL12B FGF9 FGF9 ANGPTL3 ANGPTL3 LOC103071675 LOC103071675 PTN PTN FGF10 FGF10 PDGFC PDGFC BMP10 BMP10 FGF14 FGF14 GDF7 GDF7 IL5 IL5 CSF2 CSF2 IL3 IL3 CLEC11A CLEC11A NTF4 NTF4 IL4 IL4 LOC103071959 LOC103071959 CNTF CNTF MDK MDK IL7 IL7 EPGN EPGN PPBP PPBP IL2 IL2 LOC103071404 LOC103071404 EGF EGF CSF3 CSF3 FGF21 FGF21 EREG EREG VEGFB VEGFB AREG AREG IL34 IL34 AMH AMH NRG2 NRG2 IL9 IL9 OSM OSM LIF LIF CERS1 CERS1 GDF15 GDF15 FGF20 FGF20 PSPN PSPN PGF PGF HBEGF HBEGF GDF9 GDF9 GDF1 GDF1 TGFB1 TGFB1 CDNF CDNF LOC103076006 LOC103076006 CD320 CD320 MACC1 MACC1 NRTN NRTN VEGFA VEGFA FGF22 FGF22 LOC103084052 LOC103084052 TGFB3 TGFB3 HDGF HDGF MIA MIA LOC103076283 LOC103076283 NRG3 NRG3 LOC103083779 LOC103083779 BMP4 BMP4 CSPG5 CSPG5 OSGIN2 OSGIN2 FGF16 FGF16 AMBN AMBN INHA INHA BMP3 BMP3 GMFB GMFB BMP7 BMP7 LOC103071152 LOC103071152 GDF5 GDF5 IL6 IL6 CSF1 CSF1 PROK1 PROK1 TIMP1 TIMP1 VEGFC VEGFC KITLG KITLG RABEP1 RABEP1 OSGIN1 OSGIN1 PDGFD PDGFD RABEP2 RABEP2 FGF17 FGF17 NENF NENF FBRS FBRS BMP15 BMP15 GMFG GMFG LOC103079191 LOC103079191 LOC103091465 LOC103091465 IGF1 IGF1 MANF MANF FGF4 FGF4 MSTN MSTN PDGFA PDGFA FGF18 FGF18 INHBE INHBE GDF11 GDF11 LOC103071897 LOC103071897 IGF2 IGF2 OGN OGN INHBA INHBA HGF HGF INHBC INHBC FGF1 FGF1 FGF12 FGF12 IL11 IL11 GDF3 GDF3 FGF6 FGF6 FGF23 FGF23 FAM71F2 FAM71F2 NTF3 NTF3 ARTN ARTN FAM71F1 FAM71F1 FGF2 FGF2 BMP2 BMP2 FGF8 FGF8 INHBB INHBB TDGF1 TDGF1 TGFB2 TGFB2 THBS4 THBS4 VGF VGF BMP5 BMP5 FGF3 FGF3 FGF5 FGF5 BDNF BDNF BTC BTC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF6Growth/differentiation factor 6. (461 aa)
LEFTY2Left-right determination factor. (367 aa)
TGFAProtransforming growth factor alpha. (145 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
GDF2Growth/differentiation factor 2. (431 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (257 aa)
GDF10Bone morphogenetic protein 3; Belongs to the TGF-beta family. (440 aa)
LOC103089261Bone morphogenetic protein 8B-like. (403 aa)
BMP8BBone morphogenetic protein 8B. (403 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1234 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
LOC103077537Bone morphogenetic protein 8B-like. (136 aa)
LOC103073398Left-right determination factor. (367 aa)
NODALNodal homolog. (349 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
LOC103081170Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (465 aa)
GKN1Gastrokine-1 isoform X1. (184 aa)
FIGFVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (354 aa)
BMP6Bone morphogenetic protein 6. (495 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ANGPTL3Angiopoietin-related protein 3. (463 aa)
LOC103071675C-X-C motif chemokine. (196 aa)
PTNPleiotrophin isoform X1. (181 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
BMP10Bone morphogenetic protein 10. (421 aa)
FGF14Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (252 aa)
GDF7Growth/differentiation factor 7. (457 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
IL3Interleukin-3. (144 aa)
CLEC11AC-type lectin domain family 11 member A. (324 aa)
NTF4Neurotrophin-4; Belongs to the NGF-beta family. (210 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
LOC103071959C-X-C motif chemokine. (100 aa)
CNTFCiliary neurotrophic factor. (200 aa)
MDKMidkine isoform X1. (143 aa)
IL7Interleukin-7 isoform X2. (178 aa)
EPGNEpigen isoform X1. (153 aa)
PPBPC-X-C motif chemokine. (119 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
LOC103071404C-X-C motif chemokine. (227 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EREGProepiregulin. (163 aa)
VEGFBVascular endothelial growth factor B isoform X1; Belongs to the PDGF/VEGF growth factor family. (207 aa)
AREGAmphiregulin isoform X1. (254 aa)
IL34LOW QUALITY PROTEIN: interleukin-34. (268 aa)
AMHMuellerian-inhibiting factor. (558 aa)
NRG2Pro-neuregulin-2, membrane-bound isoform. (757 aa)
IL9Interleukin-9. (141 aa)
OSMoncostatin-M. (246 aa)
LIFLeukemia inhibitory factor. (202 aa)
CERS1Ceramide synthase 1 isoform X1. (350 aa)
GDF15Growth/differentiation factor 15. (308 aa)
FGF20Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
PSPNPersephin. (181 aa)
PGFPlacenta growth factor isoform X1; Belongs to the PDGF/VEGF growth factor family. (170 aa)
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
GDF9Growth/differentiation factor 9. (454 aa)
GDF1Embryonic growth/differentiation factor 1. (370 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
CDNFCerebral dopamine neurotrophic factor. (187 aa)
LOC103076006Fibroblast growth factor 11-like; Belongs to the heparin-binding growth factors family. (174 aa)
CD320CD320 antigen. (264 aa)
MACC1LOW QUALITY PROTEIN: metastasis-associated in colon cancer protein 1. (847 aa)
NRTNNeurturin. (197 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
FGF22LOW QUALITY PROTEIN: fibroblast growth factor 22; Belongs to the heparin-binding growth factors family. (229 aa)
LOC103084052Acetylcholine receptor subunit beta-like isoform X1. (505 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
HDGFHepatoma-derived growth factor. (237 aa)
MIAMelanoma-derived growth regulatory protein. (130 aa)
LOC103076283Acetylcholine receptor subunit beta-like. (407 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (613 aa)
LOC103083779Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (261 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
CSPG5LOW QUALITY PROTEIN: chondroitin sulfate proteoglycan 5. (572 aa)
OSGIN2Oxidative stress-induced growth inhibitor 2. (551 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
AMBNAmeloblastin. (420 aa)
INHAInhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (364 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
GMFBGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
LOC103071152Acetylcholine receptor subunit beta-like. (418 aa)
GDF5Growth/differentiation factor 5. (499 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
PROK1LOW QUALITY PROTEIN: prokineticin-1. (130 aa)
TIMP1Metalloproteinase inhibitor 1. (257 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
RABEP1Rab GTPase-binding effector protein 1. (872 aa)
OSGIN1Oxidative stress-induced growth inhibitor 1. (478 aa)
PDGFDPlatelet-derived growth factor D-like isoform X1. (370 aa)
RABEP2Rab GTPase-binding effector protein 2 isoform X1. (585 aa)
FGF17Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
NENFNeudesin; Belongs to the cytochrome b5 family. (172 aa)
FBRSProbable fibrosin-1. (453 aa)
BMP15Bone morphogenetic protein 15. (403 aa)
GMFGGlia maturation factor; Belongs to the actin-binding proteins ADF family. GMF subfamily. (142 aa)
LOC103079191Bone morphogenetic protein 8B-like. (180 aa)
LOC103091465Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
MANFLOW QUALITY PROTEIN: mesencephalic astrocyte-derived neurotrophic factor. (226 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
MSTNGrowth/differentiation factor 8. (366 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
INHBEInhibin beta E chain. (351 aa)
GDF11Growth/differentiation factor 11. (404 aa)
LOC103071897Stromal cell-derived factor 1-like isoform X2; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
IGF2Insulin-like growth factor II isoform X1. (237 aa)
OGNMimecan isoform X1. (299 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (430 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
INHBCInhibin beta C chain. (352 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
FGF12Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa)
IL11Interleukin-11 isoform X1. (199 aa)
GDF3Growth/differentiation factor 3. (364 aa)
FGF6Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
FAM71F2LOW QUALITY PROTEIN: protein FAM71F2. (301 aa)
NTF3Neurotrophin-3; Seems to promote the survival of visceral and proprioceptive sensory neurons; Belongs to the NGF-beta family. (266 aa)
ARTNArtemin. (238 aa)
FAM71F1LOW QUALITY PROTEIN: protein FAM71F1. (376 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
INHBBInhibin beta B chain. (511 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (186 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
THBS4Thrombospondin-4. (961 aa)
VGFLOW QUALITY PROTEIN: VGF nerve growth factor inducible. (604 aa)
BMP5Bone morphogenetic protein 5 isoform X1. (454 aa)
FGF3Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (232 aa)
FGF5Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (266 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (248 aa)
BTCProbetacellulin. (178 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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