STRINGSTRING
T T BMP4 BMP4 GRSF1 GRSF1 LOC103069874 LOC103069874 ATM ATM NLE1 NLE1 TCF15 TCF15 DLL1 DLL1 CDX1 CDX1 TDRD5 TDRD5 BHLHE41 BHLHE41 HEY2 HEY2 HES5 HES5 POFUT1 POFUT1 SMAD3 SMAD3 PLD6 PLD6 CELSR2 CELSR2 KAT2A KAT2A LOC103076334 LOC103076334 LOC103085466 LOC103085466 OTX2 OTX2 COBL COBL LRP5 LRP5 RARG RARG PCSK5 PCSK5 CRB2 CRB2 HOXD4 HOXD4 MIB1 MIB1 KDM2B KDM2B FAM76B FAM76B BTG2 BTG2 TSHZ1 TSHZ1 POGLUT1 POGLUT1 CRKL CRKL HOXD9 HOXD9 DLL3 DLL3 ZBTB16 ZBTB16 HEY1 HEY1 ZIC3 ZIC3 WNT1 WNT1 HOXD3 HOXD3 HOXD10 HOXD10 HES6 HES6 NR2F2 NR2F2 LOC103068693 LOC103068693 HOXD13 HOXD13 HOXD8 HOXD8 HES2 HES2 RNF2 RNF2 PLXNA2 PLXNA2 TDRD6 TDRD6 PCSK6 PCSK6 EP300 EP300 FAM208A FAM208A LEF1 LEF1 HES3 HES3 CTNNBIP1 CTNNBIP1 TBX6 TBX6 LOC103089959 LOC103089959 MLLT3 MLLT3 MEOX1 MEOX1 YY1 YY1 HEYL HEYL PAX1 PAX1 SCMH1 SCMH1 FEZF2 FEZF2 BMI1 BMI1 KMT2A KMT2A CELSR1 CELSR1 TDRD7 TDRD7 WNT3A WNT3A NODAL NODAL SHH SHH ALX4 ALX4 AXIN2 AXIN2 SFRP1 SFRP1 BPTF BPTF BMPR1A BMPR1A SRF SRF WNT5A WNT5A EN1 EN1 NKX3-1 NKX3-1 LOC103090152 LOC103090152 HES1 HES1 MYF5 MYF5 FAM76A FAM76A KDM6A KDM6A LOC103079308 LOC103079308 LOC103079864 LOC103079864 SIX2 SIX2 HES7 HES7 LOC103088826 LOC103088826 FOXB1 FOXB1 NRARP NRARP TDRKH TDRKH TDRD10 TDRD10 LOC103088828 LOC103088828 PAX6 PAX6 PSEN1 PSEN1 ALDH1A2 ALDH1A2 NOTCH1 NOTCH1 TGFBR1 TGFBR1 TAF10 TAF10 TIFAB TIFAB RING1 RING1 NEUROD1 NEUROD1 NEUROG1 NEUROG1 WNT8A WNT8A CDON CDON FZD5 FZD5 TDRD15 TDRD15 GBX2 GBX2 GPC3 GPC3 SOX17 SOX17 HIPK1 HIPK1 LHX1 LHX1 NOG NOG LOC103079627 LOC103079627 HOXB7 HOXB7 HOXB2 HOXB2 LOC103079709 LOC103079709 HOXB6 HOXB6 LOC103084351 LOC103084351 FRS2 FRS2 SMAD4 SMAD4 ARC ARC OSR1 OSR1 CER1 CER1 MEOX2 MEOX2 HOXB5 HOXB5 HOXB1 HOXB1 HOXA2 HOXA2 TCAP TCAP HOXA9 HOXA9 OTX1 OTX1 MSGN1 MSGN1 FOXH1 FOXH1 CTNNB1 CTNNB1 MSX1 MSX1 HELT HELT LOC103076489 LOC103076489 SEMA3C SEMA3C SFRP2 SFRP2 HOXB9 HOXB9 HOXB4 HOXB4 PCGF2 PCGF2 HOXA7 HOXA7 HOXB8 HOXB8 WNT3 WNT3 DDIT3 DDIT3 GDF11 GDF11 PGAP1 PGAP1 HOXA6 HOXA6 HOXA3 HOXA3 HOXA5 HOXA5 HOXA11 HOXA11 HIPK2 HIPK2 MTHFSD MTHFSD EPB41L5 EPB41L5 BMPR2 BMPR2 LFNG LFNG TBX18 TBX18 GLI3 GLI3 TDRD1 TDRD1 FOXF1 FOXF1 PCDH8 PCDH8 BARX1 BARX1 LDB1 LDB1 MED12 MED12 BMP2 BMP2 XRCC2 XRCC2 LRP6 LRP6 MESP2 MESP2 FEZF1 FEZF1 EMX2 EMX2 ABI1 ABI1 FGF8 FGF8 TULP3 TULP3 MESP1 MESP1 SMO SMO SSBP3 SSBP3 TDGF1 TDGF1 CDX2 CDX2 LOC103076534 LOC103076534
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBrachyury protein isoform X1. (435 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
GRSF1G-rich sequence factor 1. (362 aa)
LOC103069874Abl interactor 1-like. (235 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
NLE1Notchless protein homolog 1 isoform X1. (485 aa)
TCF15Transcription factor 15. (197 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
CDX1Homeobox protein CDX-1. (261 aa)
TDRD5Tudor domain-containing protein 5. (1046 aa)
BHLHE41Class E basic helix-loop-helix protein 41. (483 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (352 aa)
HES5Transcription factor HES-5. (173 aa)
POFUT1GDP-fucose protein O-fucosyltransferase 1 isoform X1. (391 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
PLD6Mitochondrial cardiolipin hydrolase. (221 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2918 aa)
KAT2AHistone acetyltransferase KAT2A isoform X1. (838 aa)
LOC103076334Serine/arginine repetitive matrix protein 1-like. (440 aa)
LOC103085466Band 4.1-like protein 5-like. (256 aa)
OTX2Homeobox protein OTX2. (223 aa)
COBLProtein cordon-bleu. (1698 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
RARGRetinoic acid receptor gamma isoform X1. (458 aa)
PCSK5Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. (913 aa)
CRB2Protein crumbs homolog 2. (1281 aa)
HOXD4Homeobox protein Hox-D4. (256 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (1006 aa)
KDM2BLysine-specific demethylase 2B isoform X1. (1270 aa)
FAM76BProtein FAM76B. (339 aa)
BTG2Protein BTG2. (162 aa)
TSHZ1Teashirt homolog 1. (1096 aa)
POGLUT1Protein O-glucosyltransferase 1. (392 aa)
CRKLCrk-like protein. (303 aa)
HOXD9Homeobox protein Hox-D9. (345 aa)
DLL3LOW QUALITY PROTEIN: delta-like protein 3. (609 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16 isoform X1. (673 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1. (308 aa)
ZIC3LOW QUALITY PROTEIN: zinc finger protein ZIC 3. (468 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
HOXD3Homeobox protein Hox-D3. (432 aa)
HOXD10Homeobox protein Hox-D10. (410 aa)
HES6Transcription cofactor HES-6 isoform X1. (224 aa)
NR2F2COUP transcription factor 2-like isoform X1. (414 aa)
LOC103068693Lysine-specific demethylase 2B-like. (224 aa)
HOXD13Homeobox protein Hox-D13. (344 aa)
HOXD8Homeobox protein Hox-D8 isoform X2. (280 aa)
HES2Transcription factor HES-2. (157 aa)
RNF2E3 ubiquitin-protein ligase RING2 isoform X1. (336 aa)
PLXNA2plexin-A2. (1894 aa)
TDRD6Tudor domain-containing protein 6 isoform X1. (2100 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (1138 aa)
EP300Histone acetyltransferase p300. (2420 aa)
FAM208AProtein FAM208A isoform X1. (1667 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
HES3Transcription factor HES-3. (203 aa)
CTNNBIP1Beta-catenin-interacting protein 1 isoform X1. (81 aa)
TBX6T-box transcription factor TBX6. (436 aa)
LOC103089959Mitochondrial cardiolipin hydrolase-like. (187 aa)
MLLT3Protein AF-9. (567 aa)
MEOX1Homeobox protein MOX-1. (254 aa)
YY1Transcriptional repressor protein YY1. (412 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (323 aa)
PAX1Paired box protein Pax-1. (450 aa)
SCMH1Polycomb protein SCMH1 isoform X1. (661 aa)
FEZF2Fez family zinc finger protein 2. (461 aa)
BMI1Polycomb complex protein BMI-1. (326 aa)
KMT2AHistone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily. (3974 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3319 aa)
TDRD7Tudor domain-containing protein 7 isoform X1. (1098 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NODALNodal homolog. (349 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
ALX4Homeobox protein aristaless-like 4. (407 aa)
AXIN2Axin-2. (846 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
BPTFNucleosome-remodeling factor subunit BPTF isoform X1. (2773 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SRFSerum response factor. (510 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
EN1Homeobox protein engrailed-like. (533 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (245 aa)
LOC103090152Forkhead box protein B1-like. (275 aa)
HES1Transcription factor HES-1. (280 aa)
MYF5Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (234 aa)
FAM76AProtein FAM76A isoform X1. (307 aa)
KDM6ALysine-specific demethylase 6A-like isoform X1. (1455 aa)
LOC103079308Uncharacterized protein LOC103079308. (289 aa)
LOC103079864Homeobox protein CDX-4-like. (210 aa)
SIX2Homeobox protein SIX2. (296 aa)
HES7Transcription factor HES-7 isoform X2. (232 aa)
LOC103088826Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (143 aa)
FOXB1Forkhead box protein B1-like. (325 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
TDRKHTudor and KH domain-containing protein isoform X1. (561 aa)
TDRD10LOW QUALITY PROTEIN: tudor domain-containing protein 10. (358 aa)
LOC103088828Homeobox protein CDX-4-like. (118 aa)
PAX6Paired box protein Pax-6 isoform X1. (436 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (518 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (218 aa)
TIFABTRAF-interacting protein with FHA domain-containing protein B. (197 aa)
RING1E3 ubiquitin-protein ligase RING1. (406 aa)
NEUROD1Neurogenic differentiation factor. (356 aa)
NEUROG1Neurogenin-1. (244 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
CDONCell adhesion molecule-related/down-regulated by oncogenes. (1250 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
TDRD15LOW QUALITY PROTEIN: tudor domain-containing protein 15. (1967 aa)
GBX2Homeobox protein GBX-2. (348 aa)
GPC3Glypican-3 isoform X1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
SOX17Transcription factor SOX-17. (405 aa)
HIPK1Homeodomain-interacting protein kinase 1. (1209 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LOC103079627Uncharacterized protein LOC103079627. (499 aa)
HOXB7Homeobox protein Hox-B7. (217 aa)
HOXB2Homeobox protein Hox-B2. (349 aa)
LOC103079709NADP-dependent glyceraldehyde-3-phosphate dehydrogenase-like. (539 aa)
HOXB6Homeobox protein Hox-B6. (224 aa)
LOC103084351LOW QUALITY PROTEIN: T-box transcription factor TBX3-like. (737 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
ARCActivity-regulated cytoskeleton-associated protein. (396 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
CER1Cerberus. (273 aa)
MEOX2Homeobox protein MOX-2. (303 aa)
HOXB5Homeobox protein Hox-B5. (269 aa)
HOXB1Homeobox protein Hox-B1. (298 aa)
HOXA2Homeobox protein Hox-A2. (372 aa)
TCAPTelethonin. (167 aa)
HOXA9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (273 aa)
OTX1Homeobox protein OTX1 isoform X1. (355 aa)
MSGN1Mesogenin-1. (188 aa)
FOXH1Forkhead box protein H1. (360 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
MSX1Homeobox protein MSX-1. (303 aa)
HELTHairy and enhancer of split-related protein HELT isoform X1. (242 aa)
LOC103076489Uncharacterized protein C2orf66 homolog. (127 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
HOXB9Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
HOXB4Homeobox protein Hox-B4. (251 aa)
PCGF2Polycomb group RING finger protein 2. (344 aa)
HOXA7Homeobox protein Hox-A7. (233 aa)
HOXB8Homeobox protein Hox-B8. (243 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
GDF11Growth/differentiation factor 11. (404 aa)
PGAP1GPI inositol-deacylase; Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI- anchored proteins from the endoplasmic reticulum to the Golgi. (922 aa)
HOXA6Homeobox protein Hox-A6. (233 aa)
HOXA3Homeobox protein Hox-A3. (385 aa)
HOXA5Homeobox protein Hox-A5. (270 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
HIPK2Homeodomain-interacting protein kinase 2 isoform X1. (1180 aa)
MTHFSDMethenyltetrahydrofolate synthase domain-containing protein isoform X1. (390 aa)
EPB41L5LOW QUALITY PROTEIN: band 4.1-like protein 5. (505 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase. (378 aa)
TBX18T-box transcription factor TBX18. (612 aa)
GLI3Transcriptional activator GLI3. (1590 aa)
TDRD1Tudor domain-containing protein 1. (1046 aa)
FOXF1Forkhead box protein F1. (377 aa)
PCDH8Protocadherin-8 isoform X1. (1069 aa)
BARX1Homeobox protein BarH-like 1. (254 aa)
LDB1LIM domain-binding protein 1 isoform X1. (411 aa)
MED12Mediator of RNA polymerase II transcription subunit 12 isoform X1. (2185 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
XRCC2DNA repair protein XRCC2-like. (280 aa)
LRP6Low-density lipoprotein receptor-related protein 6 isoform X1. (1463 aa)
MESP2Mesoderm posterior protein 2. (366 aa)
FEZF1Fez family zinc finger protein 1 isoform X1. (468 aa)
EMX2Homeobox protein EMX2 isoform X1. (253 aa)
ABI1Abl interactor 1-like isoform X1. (379 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (479 aa)
MESP1Mesoderm posterior protein 1. (267 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
SSBP3Single-stranded DNA-binding protein 3 isoform X1. (388 aa)
TDGF1Growth factor; Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family. (186 aa)
CDX2Homeobox protein CDX-2. (303 aa)
LOC103076534Cytochrome P450 26C1-like; Belongs to the cytochrome P450 family. (523 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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