23 items (Lipotes vexillifer) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	ERCC8	DNA excision repair protein ERCC-8 isoform X1. (396 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	XRRA1	X-ray radiation resistance-associated protein 1. (791 aa)
	ERCC6	DNA excision repair protein ERCC-6. (1485 aa)
	NIPBL	Nipped-B protein. (2803 aa)
	XRCC4	DNA repair protein XRCC4. (333 aa)
	XRCC6	X-ray repair cross-complementing protein 6 isoform X1. (609 aa)
	LOC103069168	Uncharacterized protein LOC103069168. (404 aa)
	ANXA1	Annexin. (346 aa)
	SFRP1	Secreted frizzled-related protein 1. (308 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
	ERCC1	DNA excision repair protein ERCC-1 isoform X1. (294 aa)
	LOC103084799	Lys-63-specific deubiquitinase BRCC36-like. (139 aa)
	BRCA2	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein. (3441 aa)
	LIG4	DNA ligase. (911 aa)
	XRCC5	X-ray repair cross-complementing protein 5. (733 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	IKBIP	Inhibitor of nuclear factor kappa-B kinase-interacting protein isoform X1. (376 aa)
	BRCC3	Lys-63-specific deubiquitinase BRCC36. (183 aa)
	CCND2	G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
	XRCC2	DNA repair protein XRCC2-like. (280 aa)
	NUCKS1	Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1. (243 aa)
	BLM	Bloom syndrome protein isoform X1. (1430 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BLM	A0A340WCK4	A0A340YF25	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Bloom syndrome protein isoform X1.	0.875
ATM	BRCA2	A0A340WCK4	A0A340XSP0	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	0.896
ATM	BRCC3	A0A340WCK4	A0A340Y269	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Lys-63-specific deubiquitinase BRCC36.	0.487
ATM	ERCC1	A0A340WCK4	A0A340XHT3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA excision repair protein ERCC-1 isoform X1.	0.613
ATM	LIG4	A0A340WCK4	A0A340XTX4	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA ligase.	0.647
ATM	LOC103084799	A0A340WCK4	A0A340XRS1	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Lys-63-specific deubiquitinase BRCC36-like.	0.487
ATM	MSH2	A0A340WCK4	A0A340XF26	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.585
ATM	XRCC2	A0A340WCK4	A0A340YBP9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair protein XRCC2-like.	0.736
ATM	XRCC5	A0A340WCK4	A0A340XUW7	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 5.	0.862
ATM	XRCC6	A0A340WCK4	A0A340WY81	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	X-ray repair cross-complementing protein 6 isoform X1.	0.875
BLM	ATM	A0A340YF25	A0A340WCK4	Bloom syndrome protein isoform X1.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.875
BLM	BRCA2	A0A340YF25	A0A340XSP0	Bloom syndrome protein isoform X1.	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	0.768
BLM	ERCC1	A0A340YF25	A0A340XHT3	Bloom syndrome protein isoform X1.	DNA excision repair protein ERCC-1 isoform X1.	0.561
BLM	MSH2	A0A340YF25	A0A340XF26	Bloom syndrome protein isoform X1.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.691
BLM	XRCC2	A0A340YF25	A0A340YBP9	Bloom syndrome protein isoform X1.	DNA repair protein XRCC2-like.	0.661
BLM	XRCC5	A0A340YF25	A0A340XUW7	Bloom syndrome protein isoform X1.	X-ray repair cross-complementing protein 5.	0.669
BLM	XRCC6	A0A340YF25	A0A340WY81	Bloom syndrome protein isoform X1.	X-ray repair cross-complementing protein 6 isoform X1.	0.812
BRCA2	ATM	A0A340XSP0	A0A340WCK4	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.896
BRCA2	BLM	A0A340XSP0	A0A340YF25	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Bloom syndrome protein isoform X1.	0.768
BRCA2	BRCC3	A0A340XSP0	A0A340Y269	LOW QUALITY PROTEIN: breast cancer type 2 susceptibility protein.	Lys-63-specific deubiquitinase BRCC36.	0.446