23 items (Lipotes vexillifer) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Your Input:
	LOC103083349	Cytochrome P450 1B1-like; Belongs to the cytochrome P450 family. (543 aa)
	SULF2	Extracellular sulfatase Sulf-2 isoform X2. (857 aa)
	IL1B	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
	IL1A	Interleukin-1; Belongs to the IL-1 family. (265 aa)
	SULF1	Extracellular sulfatase Sulf-1. (1096 aa)
	HPSE	Heparanase isoform X1. (542 aa)
	CCBE1	Collagen and calcium-binding EGF domain-containing protein 1. (407 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (727 aa)
	C5	LOW QUALITY PROTEIN: complement C5. (1677 aa)
	ATF4	Cyclic AMP-dependent transcription factor ATF-4. (350 aa)
	NODAL	Nodal homolog. (349 aa)
	C5AR1	C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	RORA	LOW QUALITY PROTEIN: nuclear receptor ROR-alpha. (527 aa)
	CXCL17	VEGF coregulated chemokine 1. (119 aa)
	ARNT	Aryl hydrocarbon receptor nuclear translocator isoform X1. (790 aa)
	ADORA2B	Adenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
	FLT4	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1594 aa)
	NOX1	LOW QUALITY PROTEIN: NADPH oxidase 1. (562 aa)
	EIF2AK3	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1. (1118 aa)
	LOC103073470	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1156 aa)
	C3AR1	C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family. (498 aa)
	ISL1	Insulin gene enhancer protein ISL-1. (349 aa)
	HIF1A	Hypoxia-inducible factor 1-alpha isoform X2. (822 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNT	HIF1A	A0A340XMQ4	A0A340YH44	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Hypoxia-inducible factor 1-alpha isoform X2.	0.999
ARNT	LOC103083349	A0A340XMQ4	A0A340WBG1	Aryl hydrocarbon receptor nuclear translocator isoform X1.	Cytochrome P450 1B1-like; Belongs to the cytochrome P450 family.	0.559
ARNT	RORA	A0A340XMQ4	A0A340XFQ7	Aryl hydrocarbon receptor nuclear translocator isoform X1.	LOW QUALITY PROTEIN: nuclear receptor ROR-alpha.	0.448
ATF4	EIF2AK3	A0A340WXH5	A0A340Y523	Cyclic AMP-dependent transcription factor ATF-4.	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.	0.947
BRCA1	LOC103073470	A0A340WSA7	A0A340Y5J9	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.900
C3AR1	C5	A0A340YDC4	A0A340WXF0	C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family.	LOW QUALITY PROTEIN: complement C5.	0.798
C3AR1	C5AR1	A0A340YDC4	A0A340XF55	C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family.	C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.447
C5	C3AR1	A0A340WXF0	A0A340YDC4	LOW QUALITY PROTEIN: complement C5.	C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family.	0.798
C5	C5AR1	A0A340WXF0	A0A340XF55	LOW QUALITY PROTEIN: complement C5.	C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family.	0.994
C5AR1	C3AR1	A0A340XF55	A0A340YDC4	C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family.	C3a anaphylatoxin chemotactic receptor; Belongs to the G-protein coupled receptor 1 family.	0.447
C5AR1	C5	A0A340XF55	A0A340WXF0	C5a anaphylatoxin chemotactic receptor 1; Belongs to the G-protein coupled receptor 1 family.	LOW QUALITY PROTEIN: complement C5.	0.994
CCBE1	FLT4	A0A340WRD2	A0A340Y180	Collagen and calcium-binding EGF domain-containing protein 1.	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.549
EIF2AK3	ATF4	A0A340Y523	A0A340WXH5	Eukaryotic translation initiation factor 2-alpha kinase 3 isoform X1.	Cyclic AMP-dependent transcription factor ATF-4.	0.947
FLT4	CCBE1	A0A340Y180	A0A340WRD2	Vascular endothelial growth factor receptor 3; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	Collagen and calcium-binding EGF domain-containing protein 1.	0.549
HIF1A	ARNT	A0A340YH44	A0A340XMQ4	Hypoxia-inducible factor 1-alpha isoform X2.	Aryl hydrocarbon receptor nuclear translocator isoform X1.	0.999
HIF1A	IL1B	A0A340YH44	A0A340WC10	Hypoxia-inducible factor 1-alpha isoform X2.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.680
IL1A	IL1B	A0A340WGC1	A0A340WC10	Interleukin-1; Belongs to the IL-1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.999
IL1B	HIF1A	A0A340WC10	A0A340YH44	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Hypoxia-inducible factor 1-alpha isoform X2.	0.680
IL1B	IL1A	A0A340WC10	A0A340WGC1	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1; Belongs to the IL-1 family.	0.999
IL1B	NOX1	A0A340WC10	A0A340Y2U9	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	LOW QUALITY PROTEIN: NADPH oxidase 1.	0.473