(37 nodes) Peptidase activator activity network (Lipotes vexillifer)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CTSH	Pro-cathepsin H isoform X1; Belongs to the peptidase C1 family. (335 aa)
	LOC103086145	ATP-dependent protease subunit HslV-like. (221 aa)
	PCOLCE	Procollagen C-endopeptidase enhancer 1. (455 aa)
	CTSC	Dipeptidyl peptidase 1 isoform X1; Belongs to the peptidase C1 family. (463 aa)
	PSMD14	26S proteasome non-ATPase regulatory subunit 14. (310 aa)
	FN1	LOW QUALITY PROTEIN: fibronectin. (2483 aa)
	NKX3-1	Homeobox protein Nkx-3.1 isoform X1. (245 aa)
	LOC103072305	Bcl-2-like protein 13-like. (127 aa)
	LOC103074134	Platelet receptor Gi24. (311 aa)
	PRSS22	Brain-specific serine protease 4; Belongs to the peptidase S1 family. (325 aa)
	ATP2A3	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1001 aa)
	WDR48	WD repeat-containing protein 48 isoform X1. (677 aa)
	EBAG9	Receptor-binding cancer antigen expressed on SiSo cells; May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. (213 aa)
	PSME4	Proteasome activator complex subunit 4. (1845 aa)
	APH1B	Gamma-secretase subunit APH-1B isoform X1. (257 aa)
	SFRP2	Secreted frizzled-related protein 2. (294 aa)
	ADRM1	Proteasomal ubiquitin receptor ADRM1 isoform X1. (418 aa)
	BAD	Bcl2 antagonist of cell death. (168 aa)
	APH1A	Gamma-secretase subunit APH-1A isoform X1. (340 aa)
	GNB2L1	Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
	TMEM198	Transmembrane protein 198. (360 aa)
	PCOLCE2	Procollagen C-endopeptidase enhancer 2. (417 aa)
	PSME1	Proteasome activator complex subunit 1 isoform X1. (249 aa)
	PSME2	Proteasome activator complex subunit 2. (239 aa)
	CLPX	ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial. (633 aa)
	PSME3	Proteasome activator complex subunit 3 isoform X1. (272 aa)
	NLRC4	NLR family CARD domain-containing protein 4. (1024 aa)
	FGL2	Fibroleukin. (440 aa)
	LOC103077715	ATP-dependent protease subunit HslV-like. (187 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	TANK	TRAF family member-associated NF-kappa-B activator isoform X1. (530 aa)
	FBLN1	Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (706 aa)
	LOC103072472	Proteasome activator complex subunit 2-like. (239 aa)
	PSENEN	Gamma-secretase subunit PEN-2. (101 aa)
	BCL2L13	Bcl-2-like protein 13. (444 aa)
	LOC103085856	ATP-dependent protease ATPase subunit HslU1-like. (447 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1248 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADRM1	LOC103072472	A0A340XTB2	A0A340YDX1	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome activator complex subunit 2-like.	0.612
ADRM1	PSMD14	A0A340XTB2	A0A340XCX0	Proteasomal ubiquitin receptor ADRM1 isoform X1.	26S proteasome non-ATPase regulatory subunit 14.	0.945
ADRM1	PSME1	A0A340XTB2	A0A340WEC4	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome activator complex subunit 1 isoform X1.	0.573
ADRM1	PSME2	A0A340XTB2	A0A340WK17	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome activator complex subunit 2.	0.612
ADRM1	PSME3	A0A340XTB2	A0A340WMJ7	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome activator complex subunit 3 isoform X1.	0.702
ADRM1	PSME4	A0A340XTB2	A0A340Y1N0	Proteasomal ubiquitin receptor ADRM1 isoform X1.	Proteasome activator complex subunit 4.	0.802
APAF1	TMEM198	A0A340Y6U3	A0A340W8X5	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Transmembrane protein 198.	0.733
APH1A	APH1B	A0A340XQB5	A0A340Y0Y1	Gamma-secretase subunit APH-1A isoform X1.	Gamma-secretase subunit APH-1B isoform X1.	0.902
APH1A	PSENEN	A0A340XQB5	A0A340YDJ1	Gamma-secretase subunit APH-1A isoform X1.	Gamma-secretase subunit PEN-2.	0.994
APH1B	APH1A	A0A340Y0Y1	A0A340XQB5	Gamma-secretase subunit APH-1B isoform X1.	Gamma-secretase subunit APH-1A isoform X1.	0.902
APH1B	PSENEN	A0A340Y0Y1	A0A340YDJ1	Gamma-secretase subunit APH-1B isoform X1.	Gamma-secretase subunit PEN-2.	0.996
CTSC	CTSH	A0A340XDE1	A0A340XE54	Dipeptidyl peptidase 1 isoform X1; Belongs to the peptidase C1 family.	Pro-cathepsin H isoform X1; Belongs to the peptidase C1 family.	0.431
CTSH	CTSC	A0A340XE54	A0A340XDE1	Pro-cathepsin H isoform X1; Belongs to the peptidase C1 family.	Dipeptidyl peptidase 1 isoform X1; Belongs to the peptidase C1 family.	0.431
FGL2	LOC103074134	A0A340WSW5	A0A340X6Q4	Fibroleukin.	Platelet receptor Gi24.	0.470
GNB2L1	PSMD14	A0A340XNX6	A0A340XCX0	Guanine nucleotide-binding protein subunit beta-2-like 1.	26S proteasome non-ATPase regulatory subunit 14.	0.423
LOC103072472	ADRM1	A0A340YDX1	A0A340XTB2	Proteasome activator complex subunit 2-like.	Proteasomal ubiquitin receptor ADRM1 isoform X1.	0.612
LOC103072472	PSMD14	A0A340YDX1	A0A340XCX0	Proteasome activator complex subunit 2-like.	26S proteasome non-ATPase regulatory subunit 14.	0.599
LOC103072472	PSME1	A0A340YDX1	A0A340WEC4	Proteasome activator complex subunit 2-like.	Proteasome activator complex subunit 1 isoform X1.	0.999
LOC103072472	PSME2	A0A340YDX1	A0A340WK17	Proteasome activator complex subunit 2-like.	Proteasome activator complex subunit 2.	0.900
LOC103072472	PSME3	A0A340YDX1	A0A340WMJ7	Proteasome activator complex subunit 2-like.	Proteasome activator complex subunit 3 isoform X1.	0.432