STRINGSTRING
CADPS CADPS DOC2A DOC2A ITGAM ITGAM DRD2 DRD2 SEPT1 SEPT1 STX1B STX1B RABGEF1 RABGEF1 EXPH5 EXPH5 KIAA0100 KIAA0100 SLC4A8 SLC4A8 BAIAP3 BAIAP3 PLA2G3 PLA2G3 HYAL3 HYAL3 RAB3C RAB3C ATP9A ATP9A SYNPR SYNPR LRRK2 LRRK2 CSPG5 CSPG5 MICAL1 MICAL1 SYK SYK BACE1 BACE1 CDK5R2 CDK5R2 SNX4 SNX4 CACNB2 CACNB2 ATP2A2 ATP2A2 SCAMP5 SCAMP5 ADCY1 ADCY1 SYP SYP RAP1A RAP1A LGI3 LGI3 GIT1 GIT1 STXBP5L STXBP5L LOC103068503 LOC103068503 SYT12 SYT12 SYT1 SYT1 LOC103079561 LOC103079561 IL1RAPL1 IL1RAPL1 RAB2B RAB2B SEPT4 SEPT4 RAB15 RAB15 BCR BCR FGB FGB SYT3 SYT3 TSG101 TSG101 SDC1 SDC1 VPS4B VPS4B APBA1 APBA1 RIMS2 RIMS2 VSNL1 VSNL1 LAMP1 LAMP1 SNF8 SNF8 RAB7A RAB7A CHRM2 CHRM2 TPCN2 TPCN2 SYT8 SYT8 SYT17 SYT17 CD84 CD84 STX1A STX1A ZP3 ZP3 BRAF BRAF DGKI DGKI RAB8B RAB8B FOXF1 FOXF1 RPH3A RPH3A SYTL4 SYTL4 NCKAP1L NCKAP1L LOC103087242 LOC103087242 SYT5 SYT5 CDK5 CDK5 ADRA2A ADRA2A LOC103083735 LOC103083735 VAMP8 VAMP8 GIPC1 GIPC1 CACNA1A CACNA1A LOC103088976 LOC103088976 LOC103077154 LOC103077154 RAB10 RAB10 PFN2 PFN2 SEPT2 SEPT2 REST REST CNR1 CNR1 BLK BLK FES FES RAB5A RAB5A STXBP1 STXBP1 DNM1 DNM1 CD160 CD160 LOC103071181 LOC103071181 CHRNA5 CHRNA5 CADPS2 CADPS2 LOC103070824 LOC103070824 LOC103070646 LOC103070646 SPHK2 SPHK2 RAB24 RAB24 HAP1 HAP1 LYN LYN FBXL20 FBXL20 RALA RALA NLGN1 NLGN1 LOC103088397 LOC103088397 HGS HGS CACNB4 CACNB4 SYT6 SYT6 RAP1B RAP1B AP1G1 AP1G1 PRAM1 PRAM1 ADORA2B ADORA2B FER FER VPS18 VPS18 SEPT5 SEPT5 SYT9 SYT9 SYT7 SYT7 RAB3B RAB3B F2RL1 F2RL1 FGR FGR ATP13A2 ATP13A2 NOTCH1 NOTCH1 IL13 IL13 DTNBP1 DTNBP1 RAB3A RAB3A RAB8A RAB8A RAPGEF4 RAPGEF4 STAM STAM GIPC2 GIPC2 LOC103077822 LOC103077822 RAB3D RAB3D GIPC3 GIPC3 SYT11 SYT11 PREPL PREPL PARK2 PARK2 CHMP2A CHMP2A RAB27B RAB27B RAB9A RAB9A CACNA1B CACNA1B LOC103090669 LOC103090669 CD177 CD177 RAB12 RAB12 SYT15 SYT15 SNAPIN SNAPIN RAB13 RAB13 GRIN3A GRIN3A SYT2 SYT2 SYT13 SYT13 ANXA1 ANXA1 RAB33B RAB33B CD300A CD300A UNC13D UNC13D RPH3AL RPH3AL RAB27A RAB27A DOC2B DOC2B RAC2 RAC2 CACNA1H CACNA1H PDPK1 PDPK1 CACNA1I CACNA1I STXBP5 STXBP5 RAB26 RAB26 STXBP3 STXBP3 P2RX7 P2RX7 DVL1 DVL1 VPS4A VPS4A GSK3B GSK3B SYT4 SYT4 LOC103083537 LOC103083537 CFTR CFTR PRKCB PRKCB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CADPSCalcium-dependent secretion activator 1 isoform X6. (1348 aa)
DOC2ADouble C2-like domain-containing protein alpha isoform X1. (428 aa)
ITGAMIntegrin alpha-M; Belongs to the integrin alpha chain family. (1152 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SEPT1Septin-1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (367 aa)
STX1Bsyntaxin-1B isoform X2; Belongs to the syntaxin family. (291 aa)
RABGEF1Rab5 GDP/GTP exchange factor isoform X1. (492 aa)
EXPH5LOW QUALITY PROTEIN: exophilin-5. (1979 aa)
KIAA0100UPF0378 protein KIAA0100 homolog. (2233 aa)
SLC4A8Anion exchange protein. (1092 aa)
BAIAP3BAI1-associated protein 3 isoform X1. (1152 aa)
PLA2G3Group 3 secretory phospholipase A2. (516 aa)
HYAL3Hyaluronidase. (513 aa)
RAB3CRas-related protein Rab-3C. (227 aa)
ATP9APhospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1047 aa)
SYNPRSynaptoporin isoform X1. (276 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2-like. (920 aa)
CSPG5LOW QUALITY PROTEIN: chondroitin sulfate proteoglycan 5. (572 aa)
MICAL1Protein-methionine sulfoxide oxidase MICAL1 isoform X1. (1065 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
BACE1Beta-secretase 1 isoform X1; Belongs to the peptidase A1 family. (498 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (369 aa)
SNX4Sorting nexin-4. (450 aa)
CACNB2Voltage-dependent L-type calcium channel subunit beta-2 isoform X1. (651 aa)
ATP2A2Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1039 aa)
SCAMP5Secretory carrier-associated membrane protein. (330 aa)
ADCY1Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1134 aa)
SYPSynaptophysin. (313 aa)
RAP1ARas-related protein Rap-1A. (184 aa)
LGI3Leucine-rich repeat LGI family member 3. (548 aa)
GIT1ARF GTPase-activating protein GIT1 isoform X1. (770 aa)
STXBP5LSyntaxin-binding protein 5-like. (1115 aa)
LOC103068503LOW QUALITY PROTEIN: fibrinogen gamma-B chain-like. (445 aa)
SYT12Synaptotagmin-12 isoform X1. (421 aa)
SYT1Synaptotagmin-1 isoform X1. (422 aa)
LOC103079561LOW QUALITY PROTEIN: double C2-like domain-containing protein gamma-like. (425 aa)
IL1RAPL1Interleukin-1 receptor accessory protein-like 1. (622 aa)
RAB2BRas-related protein Rab-2B isoform X1. (216 aa)
SEPT4Septin-4 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (477 aa)
RAB15Ras-related protein Rab-15. (212 aa)
BCRBreakpoint cluster region protein isoform X2. (1272 aa)
FGBFibrinogen beta chain isoform X1. (488 aa)
SYT3Synaptotagmin-3. (591 aa)
TSG101Tumor susceptibility gene 101 protein. (391 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (310 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (443 aa)
APBA1Amyloid beta A4 precursor protein-binding family A member 1-like. (843 aa)
RIMS2Regulating synaptic membrane exocytosis protein 2 isoform X1. (1557 aa)
VSNL1Visinin-like protein 1 isoform X1. (208 aa)
LAMP1Lysosome-associated membrane glycoprotein 1. (414 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
RAB7ARas-related protein Rab-7a. (207 aa)
CHRM2Muscarinic acetylcholine receptor; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. (466 aa)
TPCN2Two pore calcium channel protein 2. (758 aa)
SYT8Synaptotagmin-8. (360 aa)
SYT17Synaptotagmin-17. (474 aa)
CD84SLAM family member 5. (214 aa)
STX1Asyntaxin-1A; Belongs to the syntaxin family. (288 aa)
ZP3Zona pellucida sperm-binding protein 3. (421 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
DGKIDiacylglycerol kinase. (1078 aa)
RAB8BRas-related protein Rab-8B isoform X1. (207 aa)
FOXF1Forkhead box protein F1. (377 aa)
RPH3Arabphilin-3A isoform X1. (703 aa)
SYTL4Synaptotagmin-like protein 4. (672 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
LOC103087242Profilin; Belongs to the profilin family. (134 aa)
SYT5Synaptotagmin-5 isoform X1. (386 aa)
CDK5Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
ADRA2Aalpha-2A adrenergic receptor. (462 aa)
LOC103083735E3 ubiquitin-protein ligase parkin-like. (141 aa)
VAMP8Vesicle-associated membrane protein 8. (99 aa)
GIPC1PDZ domain-containing protein GIPC1 isoform X1. (333 aa)
CACNA1AVoltage-dependent P/Q-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1A gives rise to P and/or Q- type calcium currents. (2295 aa)
LOC103088976Ras-related protein Rap-1b-like isoform X1. (165 aa)
LOC103077154Uncharacterized protein C12orf4 homolog. (566 aa)
RAB10Ras-related protein Rab-10. (200 aa)
PFN2Profilin; Belongs to the profilin family. (143 aa)
SEPT2Septin-2 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (371 aa)
RESTRE1-silencing transcription factor-like isoform X1. (1002 aa)
CNR1Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] (472 aa)
BLKTyrosine-protein kinase. (501 aa)
FESTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
STXBP1Syntaxin-binding protein 1 isoform X1; Belongs to the STXBP/unc-18/SEC1 family. (603 aa)
DNM1Dynamin-1 isoform X3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
CD160LOW QUALITY PROTEIN: CD160 molecule. (177 aa)
LOC103071181Synaptotagmin-10-like. (424 aa)
CHRNA5Neuronal acetylcholine receptor subunit alpha-5. (475 aa)
CADPS2Calcium-dependent secretion activator 2. (1190 aa)
LOC103070824Leucine-rich repeat serine/threonine-protein kinase 2-like. (1609 aa)
LOC103070646Uncharacterized protein. (454 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
RAB24Ras-related protein Rab-24. (203 aa)
HAP1LOW QUALITY PROTEIN: huntingtin-associated protein 1. (550 aa)
LYNTyrosine-protein kinase. (516 aa)
FBXL20F-box/LRR-repeat protein 20 isoform X1. (436 aa)
RALARas-related protein Ral-A. (206 aa)
NLGN1Neuroligin-1 isoform X1. (863 aa)
LOC103088397Vesicle-associated membrane protein 7-like isoform X1; Belongs to the synaptobrevin family. (220 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
CACNB4Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
SYT6Synaptotagmin-6. (509 aa)
RAP1BRas-related protein Rap-1b isoform X1. (184 aa)
AP1G1AP-1 complex subunit gamma. (829 aa)
PRAM1PML-RARA-regulated adapter molecule 1. (638 aa)
ADORA2BAdenosine receptor A2; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family. (333 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
VPS18Vacuolar protein sorting-associated protein 18 homolog. (973 aa)
SEPT5Septin-5; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (369 aa)
SYT9Synaptotagmin-9. (589 aa)
SYT7Synaptotagmin-7. (403 aa)
RAB3BRas-related protein Rab-3B. (219 aa)
F2RL1Proteinase-activated receptor 2. (397 aa)
FGRTyrosine-protein kinase. (537 aa)
ATP13A2Cation-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. (1174 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
IL13Interleukin-13. (132 aa)
DTNBP1Dysbindin. (341 aa)
RAB3ARas-related protein Rab-3A. (220 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
RAPGEF4Rap guanine nucleotide exchange factor 4 isoform X1. (1011 aa)
STAMSignal transducing adapter molecule 1. (507 aa)
GIPC2PDZ domain-containing protein GIPC2. (311 aa)
LOC103077822Profilin; Belongs to the profilin family. (127 aa)
RAB3DRas-related protein Rab-3D. (219 aa)
GIPC3PDZ domain-containing protein GIPC3. (318 aa)
SYT11Synaptotagmin-11. (428 aa)
PREPLProlyl endopeptidase-like isoform X1. (727 aa)
PARK2RBR-type E3 ubiquitin transferase. (274 aa)
CHMP2ACharged multivesicular body protein 2a. (222 aa)
RAB27BRas-related protein Rab-27B. (126 aa)
RAB9ARas-related protein Rab-9A. (201 aa)
CACNA1BVoltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2261 aa)
LOC103090669RE1-silencing transcription factor-like isoform X1. (986 aa)
CD177LOW QUALITY PROTEIN: CD177 antigen. (449 aa)
RAB12Ras-related protein Rab-12. (244 aa)
SYT15Synaptotagmin-15. (484 aa)
SNAPINSNARE-associated protein Snapin; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling; Belongs to t [...] (136 aa)
RAB13Ras-related protein Rab-13. (203 aa)
GRIN3AGlutamate receptor ionotropic, NMDA 3A; Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. (1115 aa)
SYT2Synaptotagmin-2 isoform X1. (422 aa)
SYT13Synaptotagmin-13. (425 aa)
ANXA1Annexin. (346 aa)
RAB33BRas-related protein Rab-33B. (229 aa)
CD300ACMRF35-like molecule 8. (303 aa)
UNC13DProtein unc-13 homolog D. (1090 aa)
RPH3ALRab effector Noc2. (289 aa)
RAB27ARas-related protein Rab-27A. (221 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
RAC2Ras-related C3 botulinum toxin substrate 2. (192 aa)
CACNA1HLOW QUALITY PROTEIN: voltage-dependent T-type calcium channel subunit alpha-1H. (2346 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
CACNA1IVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2110 aa)
STXBP5LOW QUALITY PROTEIN: syntaxin-binding protein 5. (1154 aa)
RAB26Ras-related protein Rab-26. (256 aa)
STXBP3Syntaxin-binding protein 3; Belongs to the STXBP/unc-18/SEC1 family. (592 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1 isoform X2. (699 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (437 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
SYT4Synaptotagmin-4-like isoform X1. (425 aa)
LOC103083537Interleukin-13-like. (81 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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