STRINGSTRING
CUL3 CUL3 TGFB2 TGFB2 NKX2-3 NKX2-3 BTRC BTRC FGF8 FGF8 EDA EDA SOSTDC1 SOSTDC1 LOC103077051 LOC103077051 PHB2 PHB2 STAT6 STAT6 GLI3 GLI3 PLXNA1 PLXNA1 SEMA3C SEMA3C FOXA1 FOXA1 NFIB NFIB HOXA13 HOXA13 VDR VDR NFKB1 NFKB1 FRS2 FRS2 LOC103084351 LOC103084351 MED1 MED1 HOXB13 HOXB13 NOG NOG TBX2 TBX2 BCL2 BCL2 SCRIB SCRIB LAMA5 LAMA5 PLAG1 PLAG1 GDF7 GDF7 SERPINB5 SERPINB5 AREG AREG ESRP2 ESRP2 PLXND1 PLXND1 FGL1 FGL1 FGF10 FGF10 EPHA2 EPHA2 NOTCH1 NOTCH1 TGFB1 TGFB1 PAX6 PAX6 LRRC1 LRRC1 TP63 TP63 NTN1 NTN1 TGFB3 TGFB3 LOC103079308 LOC103079308 BSX BSX ESR1 ESR1 NKX3-1 NKX3-1 KDM5B KDM5B TWSG1 TWSG1 WNT5A WNT5A CCL11 CCL11 NRG3 NRG3 SFRP1 SFRP1 ELF3 ELF3 NOTCH2 NOTCH2 LOC103088284 LOC103088284 SHH SHH POLB POLB SLC9A3R1 SLC9A3R1 EDAR EDAR CSMD2 CSMD2 FGF7 FGF7 TGFA TGFA SOX9 SOX9 HOXD13 HOXD13 CAV1 CAV1 TNC TNC DDR1 DDR1 PROX1 PROX1 MKI67 MKI67 RARG RARG PTCH1 PTCH1 LRP5 LRP5 TGM2 TGM2 CSF1 CSF1 IL6 IL6 BMP7 BMP7 PML PML RXFP1 RXFP1 CEBPB CEBPB MSN MSN MST1 MST1 SRC SRC FEM1B FEM1B AR AR BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CUL3Cullin-3; Belongs to the cullin family. (653 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
NKX2-3Homeobox protein Nkx-2.3. (365 aa)
BTRCF-box/WD repeat-containing protein 1A. (579 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
EDAectodysplasin-A isoform X1; Belongs to the tumor necrosis factor family. (391 aa)
SOSTDC1Sclerostin domain-containing protein 1. (206 aa)
LOC103077051CUB and sushi domain-containing protein 1-like. (431 aa)
PHB2Prohibitin. (299 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
GLI3Transcriptional activator GLI3. (1590 aa)
PLXNA1plexin-A1. (1890 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
NFIBNuclear factor 1; Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. (576 aa)
HOXA13Homeobox protein Hox-A13. (297 aa)
VDRVitamin D3 receptor isoform X1. (427 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit isoform X1. (977 aa)
FRS2Fibroblast growth factor receptor substrate 2. (508 aa)
LOC103084351LOW QUALITY PROTEIN: T-box transcription factor TBX3-like. (737 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
HOXB13Homeobox protein Hox-B13. (285 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
TBX2T-box transcription factor TBX2. (875 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (1659 aa)
LAMA5Laminin subunit alpha-5. (3689 aa)
PLAG1Zinc finger protein PLAG1 isoform X1. (499 aa)
GDF7Growth/differentiation factor 7. (457 aa)
SERPINB5Serpin B5; Belongs to the serpin family. (375 aa)
AREGAmphiregulin isoform X1. (254 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
PLXND1plexin-D1. (1747 aa)
FGL1Fibrinogen-like protein 1 isoform X1. (315 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PAX6Paired box protein Pax-6 isoform X1. (436 aa)
LRRC1Leucine-rich repeat-containing protein 1. (524 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
NTN1Netrin-1 isoform X1. (604 aa)
TGFB3Transforming growth factor beta-3. (456 aa)
LOC103079308Uncharacterized protein LOC103079308. (289 aa)
BSXBrain-specific homeobox protein homolog. (232 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (245 aa)
KDM5BLysine-specific demethylase 5B. (1352 aa)
TWSG1Twisted gastrulation protein homolog 1. (222 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
CCL11C-C motif chemokine. (99 aa)
NRG3Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (613 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
ELF3ETS-related transcription factor Elf-3. (372 aa)
NOTCH2Neurogenic locus notch homolog protein 2-like. (2471 aa)
LOC103088284LOW QUALITY PROTEIN: selenoprotein H. (122 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
POLBDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (335 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (365 aa)
EDARTumor necrosis factor receptor superfamily member EDAR. (448 aa)
CSMD2CUB and sushi domain-containing protein 2. (3546 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
TGFAProtransforming growth factor alpha. (145 aa)
SOX9Transcription factor SOX-9 isoform X1. (509 aa)
HOXD13Homeobox protein Hox-D13. (344 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
TNCTenascin isoform X1. (2200 aa)
DDR1Tyrosine-protein kinase receptor. (923 aa)
PROX1Prospero homeobox protein 1. (737 aa)
MKI67Antigen KI-67. (2385 aa)
RARGRetinoic acid receptor gamma isoform X1. (458 aa)
PTCH1Protein patched homolog 1 isoform X1. (1448 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2 isoform X1. (687 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
PMLProtein PML. (848 aa)
RXFP1Relaxin receptor 1 isoform X1. (758 aa)
CEBPBCCAAT/enhancer-binding protein. (345 aa)
MSNMoesin. (577 aa)
MST1Hepatocyte growth factor-like protein; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
SRCTyrosine-protein kinase. (548 aa)
FEM1BProtein fem-1 homolog B. (627 aa)
ARAndrogen receptor. (888 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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