STRINGSTRING
WIZ WIZ VPS4A VPS4A MDP1 MDP1 RASGEF1B RASGEF1B KIAA1377 KIAA1377 CDK1 CDK1 ZFYVE26 ZFYVE26 RAD21 RAD21 ARL3 ARL3 CPEB3 CPEB3 CEP55 CEP55 ANKRD45 ANKRD45 HEPACAM2 HEPACAM2 EXOC3 EXOC3 DCDC1 DCDC1 PSRC1 PSRC1 CCDC66 CCDC66 CTDP1 CTDP1 GNAI3 GNAI3 CCDC69 CCDC69 ANLN ANLN KLHDC8B KLHDC8B KIAA2022 KIAA2022 VPS37B VPS37B LOC103076697 LOC103076697 ARF6 ARF6 MICAL1 MICAL1 URB2 URB2 ANKRD54 ANKRD54 SEPT7 SEPT7 PPP1CC PPP1CC LOC103085427 LOC103085427 LOC103069649 LOC103069649 USP8 USP8 CTNND1 CTNND1 SCCPDH SCCPDH MARK4 MARK4 KIF14 KIF14 ARL8A ARL8A YPEL5 YPEL5 DCTN3 DCTN3 CEP44 CEP44 LOC103086084 LOC103086084 GDI1 GDI1 LOC103089543 LOC103089543 SDCCAG3 SDCCAG3 NUDC NUDC CLIC4 CLIC4 JTB JTB CYLD CYLD CHMP2A CHMP2A KATNA1 KATNA1 CHMP7 CHMP7 CDCA8 CDCA8 SEPT12 SEPT12 AURKB AURKB MYH10 MYH10 SSNA1 SSNA1 APC2 APC2 PIN1 PIN1 BCL3 BCL3 DNM2 DNM2 TEX14 TEX14 MAPRE3 MAPRE3 AGBL5 AGBL5 KATNAL1 KATNAL1 SEPT2 SEPT2 TTC28 TTC28 HSPA5 HSPA5 PDXP PDXP LOC103082673 LOC103082673 EML4 EML4 PKP4 PKP4 LOC103068347 LOC103068347 UVRAG UVRAG GEM GEM RAB11FIP4 RAB11FIP4 RACGAP1 RACGAP1 ERH ERH SLC2A1 SLC2A1 RHOA RHOA PLK1 PLK1 TBCK TBCK ARL8B ARL8B LZTS2 LZTS2 SVIL SVIL IQGAP1 IQGAP1 PKN1 PKN1 KLHDC8A KLHDC8A CAPG CAPG PRC1 PRC1 PKN2 PKN2 RALB RALB KIF4A KIF4A LOC103077418 LOC103077418 ALKBH4 ALKBH4 NAT10 NAT10 KLHL34 KLHL34 CHMP1A CHMP1A MICAL3 MICAL3 USP3 USP3 LOC103081730 LOC103081730 MAP10 MAP10 CHMP2B CHMP2B CHMP3 CHMP3 LOC103085022 LOC103085022 FAM175B FAM175B LYRM1 LYRM1 LOC103069598 LOC103069598 GNAI2 GNAI2 TXNDC9 TXNDC9 AGAP2 AGAP2 RNF8 RNF8 SEPT6 SEPT6 GNAI1 GNAI1 MITD1 MITD1 SIRT2 SIRT2 PIK3CB PIK3CB MAK MAK ANXA11 ANXA11 VPS4B VPS4B ECT2 ECT2 SH3GLB1 SH3GLB1 MPLKIP MPLKIP CHMP5 CHMP5 LOC103086475 LOC103086475 CHMP1B CHMP1B CHMP6 CHMP6 SPG20 SPG20 INCENP INCENP PIK3C3 PIK3C3 EML3 EML3 CENPE CENPE BIRC5 BIRC5 HNRNPU HNRNPU NUP62 NUP62 KIF20A KIF20A CCDC124 CCDC124 IST1 IST1 BIRC6 BIRC6 SPAST SPAST CENPF CENPF NEK2 NEK2 RAB11FIP3 RAB11FIP3 GNL3 GNL3 GNB2L1 GNB2L1 CHMP4C CHMP4C ZFYVE19 ZFYVE19 CRMP1 CRMP1 SEPT1 SEPT1 CENPC CENPC HSP90B1 HSP90B1 PTCH1 PTCH1 CHMP4A CHMP4A FLCN FLCN LOC103076114 LOC103076114 KEAP1 KEAP1 RCC2 RCC2 CDC42 CDC42 DTNBP1 DTNBP1 RAB8A RAB8A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
WIZProtein Wiz isoform X1. (968 aa)
VPS4AVacuolar protein sorting-associated protein 4A; Belongs to the AAA ATPase family. (437 aa)
MDP1Magnesium-dependent phosphatase 1 isoform X1. (164 aa)
RASGEF1Bras-GEF domain-containing family member 1B isoform X1. (472 aa)
KIAA1377LOW QUALITY PROTEIN: uncharacterized protein KIAA1377 homolog. (1095 aa)
CDK1Cyclin-dependent kinase 1-like isoform X1; Belongs to the protein kinase superfamily. (297 aa)
ZFYVE26Zinc finger FYVE domain-containing protein 26. (2543 aa)
RAD21Double-strand-break repair protein rad21 homolog. (630 aa)
ARL3ADP-ribosylation factor-like protein 3; Belongs to the small GTPase superfamily. Arf family. (182 aa)
CPEB3Cytoplasmic polyadenylation element-binding protein 3 isoform X1. (697 aa)
CEP55Centrosomal protein of 55 kDa. (463 aa)
ANKRD45Ankyrin repeat domain-containing protein 45. (251 aa)
HEPACAM2HEPACAM family member 2 isoform X1. (462 aa)
EXOC3Exocyst complex component 3. (745 aa)
DCDC1LOW QUALITY PROTEIN: doublecortin domain containing 1. (316 aa)
PSRC1LOW QUALITY PROTEIN: proline/serine-rich coiled-coil 1. (310 aa)
CCDC66Coiled-coil domain-containing protein 66 isoform X1. (942 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (948 aa)
GNAI3Guanine nucleotide-binding protein G(K) subunit alpha. (354 aa)
CCDC69Coiled-coil domain-containing protein 69. (352 aa)
ANLNActin-binding protein anillin. (1152 aa)
KLHDC8BKelch domain-containing protein 8B. (354 aa)
KIAA2022Uncharacterized protein KIAA2022 homolog. (1515 aa)
VPS37BVacuolar protein sorting-associated protein 37B. (289 aa)
LOC103076697Rac GTPase-activating protein 1-like. (304 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
MICAL1Protein-methionine sulfoxide oxidase MICAL1 isoform X1. (1065 aa)
URB2Unhealthy ribosome biogenesis protein 2 homolog. (1516 aa)
ANKRD54Ankyrin repeat domain-containing protein 54. (299 aa)
SEPT7Septin-7 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (437 aa)
PPP1CCSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa)
LOC103085427Nuclear pore glycoprotein p62-like. (328 aa)
LOC103069649Protein C9orf72 homolog. (481 aa)
USP8LOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase 8; Belongs to the peptidase C19 family. (1116 aa)
CTNND1Catenin delta-1 isoform X1. (978 aa)
SCCPDHSaccharopine dehydrogenase-like oxidoreductase. (405 aa)
MARK4Non-specific serine/threonine protein kinase. (761 aa)
KIF14Kinesin-like protein KIF14; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1607 aa)
ARL8AADP-ribosylation factor-like protein 8A; Belongs to the small GTPase superfamily. Arf family. (186 aa)
YPEL5Protein yippee-like; Belongs to the yippee family. (121 aa)
DCTN3Dynactin subunit 3 isoform X1. (186 aa)
CEP44Centrosomal protein of 44 kDa. (385 aa)
LOC103086084LOW QUALITY PROTEIN: serine/threonine-protein phosphatase PP1-gamma catalytic subunit B-like. (375 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (447 aa)
LOC103089543Charged multivesicular body protein 7-like. (100 aa)
SDCCAG3Serologically defined colon cancer antigen 3 homolog isoform X1. (428 aa)
NUDCNuclear migration protein nudC. (332 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
JTBProtein JTB. (146 aa)
CYLDLOW QUALITY PROTEIN: ubiquitin carboxyl-terminal hydrolase CYLD; Belongs to the peptidase C19 family. (962 aa)
CHMP2ACharged multivesicular body protein 2a. (222 aa)
KATNA1Katanin p60 ATPase-containing subunit A1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal p [...] (491 aa)
CHMP7Charged multivesicular body protein 7-like. (450 aa)
CDCA8Borealin. (280 aa)
SEPT12Septin-12; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (363 aa)
AURKBAurora kinase B isoform X1; Belongs to the protein kinase superfamily. (345 aa)
MYH10Myosin-10; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2007 aa)
SSNA1Sjoegren syndrome nuclear autoantigen 1 homolog. (119 aa)
APC2Adenomatous polyposis coli protein 2. (2237 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (163 aa)
BCL3B-cell lymphoma 3 protein. (454 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
TEX14Inactive serine/threonine-protein kinase TEX14. (1489 aa)
MAPRE3Microtubule-associated protein RP/EB family member 3 isoform X1. (301 aa)
AGBL5LOW QUALITY PROTEIN: cytosolic carboxypeptidase-like protein 5. (889 aa)
KATNAL1Katanin p60 ATPase-containing subunit A-like 1; Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neur [...] (490 aa)
SEPT2Septin-2 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (371 aa)
TTC28LOW QUALITY PROTEIN: tetratricopeptide repeat domain 28. (2113 aa)
HSPA578 kDa glucose-regulated protein; Belongs to the heat shock protein 70 family. (655 aa)
PDXPPyridoxal phosphate phosphatase; Belongs to the HAD-like hydrolase superfamily. (296 aa)
LOC103082673Putative ubiquitin carboxyl-terminal hydrolase 50-like; Belongs to the peptidase C19 family. (373 aa)
EML4Echinoderm microtubule-associated protein-like 4 isoform X2. (1006 aa)
PKP4Plakophilin-4 isoform X1. (1193 aa)
LOC103068347Kelch-like protein 9-like. (617 aa)
UVRAGUV radiation resistance-associated gene protein isoform X1. (699 aa)
GEMGTP-binding protein; Belongs to the small GTPase superfamily. RGK family. (311 aa)
RAB11FIP4Rab11 family-interacting protein 4. (810 aa)
RACGAP1Rac GTPase-activating protein 1. (344 aa)
ERHEnhancer of rudimentary homolog; May have a role in the cell cycle. (104 aa)
SLC2A1Solute carrier family 2, facilitated glucose transporter member 1-like; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (492 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
TBCKTBC domain-containing protein kinase-like protein isoform X1. (893 aa)
ARL8BLOW QUALITY PROTEIN: ADP-ribosylation factor-like protein 8B; Belongs to the small GTPase superfamily. Arf family. (244 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (668 aa)
SVILSupervillin. (2199 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1627 aa)
PKN1Serine/threonine-protein kinase N1 isoform X2. (950 aa)
KLHDC8AKelch domain-containing protein 8A. (350 aa)
CAPGMacrophage-capping protein isoform X1. (358 aa)
PRC1Protein regulator of cytokinesis 1 isoform X1. (620 aa)
PKN2Serine/threonine-protein kinase N2 isoform X1. (983 aa)
RALBRas-related protein Ral-B. (206 aa)
KIF4AChromosome-associated kinesin KIF4A; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1227 aa)
LOC103077418Uncharacterized protein C7orf43 homolog. (579 aa)
ALKBH4Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4. (302 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1025 aa)
KLHL34Kelch-like protein 34. (648 aa)
CHMP1ACharged multivesicular body protein 1a. (196 aa)
MICAL3Protein-methionine sulfoxide oxidase MICAL3 isoform X1. (1964 aa)
USP3Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (497 aa)
LOC103081730Bombesin receptor-activated protein C6orf89 homolog isoform X1. (362 aa)
MAP10Microtubule-associated protein 10. (914 aa)
CHMP2BCharged multivesicular body protein 2b isoform X1. (213 aa)
CHMP3Charged multivesicular body protein 3. (221 aa)
LOC103085022Charged multivesicular body protein 7-like. (305 aa)
FAM175BBRISC complex subunit Abro1. (424 aa)
LYRM1LYR motif-containing protein 1; Belongs to the complex I LYR family. (122 aa)
LOC103069598Chromosome alignment-maintaining phosphoprotein 1-like. (826 aa)
GNAI2LOW QUALITY PROTEIN: guanine nucleotide-binding protein G(I) subunit alpha-2. (360 aa)
TXNDC9Thioredoxin domain-containing protein 9. (226 aa)
AGAP2arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2-like isoform X1. (1193 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
SEPT6Septin-6 isoform X1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (446 aa)
GNAI1Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform X1. (354 aa)
MITD1MIT domain-containing protein 1. (255 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (389 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1064 aa)
MAKSerine/threonine-protein kinase MAK isoform X1. (648 aa)
ANXA11Annexin. (529 aa)
VPS4BVacuolar protein sorting-associated protein 4B; Belongs to the AAA ATPase family. (443 aa)
ECT2Protein ECT2 isoform X1. (933 aa)
SH3GLB1endophilin-B1 isoform X1. (402 aa)
MPLKIPM-phase-specific PLK1-interacting protein. (179 aa)
CHMP5Charged multivesicular body protein 5. (219 aa)
LOC103086475Septin-7-like; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (118 aa)
CHMP1BCharged multivesicular body protein 1b. (199 aa)
CHMP6Charged multivesicular body protein 6. (202 aa)
SPG20Spartin isoform X1. (668 aa)
INCENPInner centromere protein. (945 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (887 aa)
EML3Echinoderm microtubule-associated protein-like 3 isoform X1. (897 aa)
CENPELOW QUALITY PROTEIN: centromere-associated protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2707 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (824 aa)
NUP62Nuclear pore glycoprotein p62. (516 aa)
KIF20AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (890 aa)
CCDC124Coiled-coil domain-containing protein 124. (223 aa)
IST1IST1 homolog isoform X1. (364 aa)
BIRC6LOW QUALITY PROTEIN: baculoviral IAP repeat-containing protein 6. (4861 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (616 aa)
CENPFCentromere protein F. (3071 aa)
NEK2Serine/threonine-protein kinase Nek2 isoform X1. (445 aa)
RAB11FIP3Rab11 family-interacting protein 3. (686 aa)
GNL3Guanine nucleotide-binding protein-like 3. (547 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
CHMP4CCharged multivesicular body protein 4c. (237 aa)
ZFYVE19Zinc finger FYVE domain-containing protein 19. (398 aa)
CRMP1Dihydropyrimidinase-related protein 1 isoform X1. (686 aa)
SEPT1Septin-1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (367 aa)
CENPCCentromere protein C. (940 aa)
HSP90B1Endoplasmin. (803 aa)
PTCH1Protein patched homolog 1 isoform X1. (1448 aa)
CHMP4ACharged multivesicular body protein 4a. (222 aa)
FLCNFolliculin. (579 aa)
LOC103076114Uncharacterized protein LOC103076114. (1331 aa)
KEAP1Kelch-like ECH-associated protein 1. (624 aa)
RCC2Protein RCC2 isoform X1. (520 aa)
CDC42Cell division control protein 42 homolog isoform X1. (191 aa)
DTNBP1Dysbindin. (341 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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