STRINGSTRING
NCK2 NCK2 DLG2 DLG2 EPS8 EPS8 GRB2 GRB2 CDC42EP4 CDC42EP4 GBA2 GBA2 EVL EVL ADD2 ADD2 MLST8 MLST8 FHOD3 FHOD3 SSH2 SSH2 CAPZA3 CAPZA3 LOC103073534 LOC103073534 FAM206A FAM206A ELN ELN TMSB15A TMSB15A MYADM MYADM SPTAN1 SPTAN1 NPHS1 NPHS1 SVIL SVIL LMOD2 LMOD2 KIAA1211 KIAA1211 CAPG CAPG TMOD3 TMOD3 BAG4 BAG4 FCHSD1 FCHSD1 CCL26 CCL26 LOC103087242 LOC103087242 NCKAP1L NCKAP1L TMOD2 TMOD2 CCL24 CCL24 CDC42EP5 CDC42EP5 CTTN CTTN KANK1 KANK1 SPTBN1 SPTBN1 DLG1 DLG1 LOC103090189 LOC103090189 AVIL AVIL RICTOR RICTOR SLIT2 SLIT2 MTPN MTPN PAK3 PAK3 PTK2B PTK2B LOC103073993 LOC103073993 DBNL DBNL ESAM ESAM KANK4 KANK4 PFN3 PFN3 CSF3 CSF3 CYFIP1 CYFIP1 VILL VILL FMN1 FMN1 TWF1 TWF1 MTOR MTOR FER FER TMOD4 TMOD4 BAIAP2 BAIAP2 PIK3R2 PIK3R2 CDC42EP2 CDC42EP2 SPTBN2 SPTBN2 BBS4 BBS4 PRKCE PRKCE KANK3 KANK3 LOC103077822 LOC103077822 VASP VASP SPTBN5 SPTBN5 LOC103074616 LOC103074616 PFN1 PFN1 CAPZB CAPZB CAPZA1 CAPZA1 NCK1 NCK1 TMOD1 TMOD1 LATS1 LATS1 LMOD1 LMOD1 SPTBN4 SPTBN4 ARHGAP28 ARHGAP28 CCL11 CCL11 DAAM2 DAAM2 PFN4 PFN4 HAX1 HAX1 ALOX15 ALOX15 TMSB4X TMSB4X LRRC16A LRRC16A BAIAP2L2 BAIAP2L2 CDC42EP1 CDC42EP1 ARPC4 ARPC4 GSN GSN SNX9 SNX9 PLEKHG2 PLEKHG2 LOC103076075 LOC103076075 PYCARD PYCARD ARPC5L ARPC5L LOC103085394 LOC103085394 CORO1A CORO1A CAPZA2 CAPZA2 COTL1 COTL1 DMTN DMTN ARHGAP18 ARHGAP18 SSH3 SSH3 ARPC2 ARPC2 VIL1 VIL1 ARPC3 ARPC3 HCLS1 HCLS1 FLII FLII SSH1 SSH1 ARPC1A ARPC1A ARFGEF1 ARFGEF1 LOC103071701 LOC103071701 MKKS MKKS ARPC5 ARPC5 RASA1 RASA1 BAIAP2L1 BAIAP2L1 ARPC1B ARPC1B CCL21 CCL21 RDX RDX TMSB10 TMSB10 FAM49A FAM49A ADD1 ADD1 PFN2 PFN2 ADD3 ADD3 SPTB SPTB FCHSD2 FCHSD2 LOC103089567 LOC103089567 HIP1R HIP1R SCIN SCIN FAM49B FAM49B CDC42EP3 CDC42EP3 LMOD3 LMOD3 ARF6 ARF6 PRKCD PRKCD CYFIP2 CYFIP2 SPTA1 SPTA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NCK2Cytoplasmic protein. (376 aa)
DLG2Disks large homolog 2-like isoform X1. (905 aa)
EPS8Epidermal growth factor receptor kinase substrate 8. (812 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
CDC42EP4Cdc42 effector protein 4. (353 aa)
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (922 aa)
EVLena/VASP-like protein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (419 aa)
ADD2Beta-adducin. (743 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
FHOD3LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 3. (1436 aa)
SSH2Protein phosphatase Slingshot homolog 2. (1429 aa)
CAPZA3F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (298 aa)
LOC103073534Protein translocase subunit SECA1, chloroplastic-like. (545 aa)
FAM206ALOW QUALITY PROTEIN: family with sequence similarity 206, member A. (188 aa)
ELNLOW QUALITY PROTEIN: elastin. (800 aa)
TMSB15ALOW QUALITY PROTEIN: thymosin beta 15a. (45 aa)
MYADMLOW QUALITY PROTEIN: myeloid-associated differentiation marker. (316 aa)
SPTAN1Spectrin alpha chain, non-erythrocytic 1 isoform X1. (2477 aa)
NPHS1LOW QUALITY PROTEIN: nephrin. (1244 aa)
SVILSupervillin. (2199 aa)
LMOD2Leiomodin-2. (543 aa)
KIAA1211Uncharacterized protein KIAA1211 homolog. (1273 aa)
CAPGMacrophage-capping protein isoform X1. (358 aa)
TMOD3Tropomodulin-3. (352 aa)
BAG4BAG family molecular chaperone regulator 4. (369 aa)
FCHSD1FCH and double SH3 domains protein 1. (692 aa)
CCL26c-C motif chemokine 26. (94 aa)
LOC103087242Profilin; Belongs to the profilin family. (134 aa)
NCKAP1LNck-associated protein 1-like. (1134 aa)
TMOD2Tropomodulin-2 isoform X1. (351 aa)
CCL24c-C motif chemokine 24. (130 aa)
CDC42EP5Cdc42 effector protein 5. (153 aa)
CTTNSrc substrate cortactin isoform X1. (538 aa)
KANK1KN motif and ankyrin repeat domain-containing protein 1. (1351 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2365 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
LOC103090189Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
AVILAdvillin. (816 aa)
RICTORRapamycin-insensitive companion of mTOR-like isoform X1. (1580 aa)
SLIT2LOW QUALITY PROTEIN: slit homolog 2 protein. (1521 aa)
MTPNMyotrophin. (118 aa)
PAK3Serine/threonine-protein kinase PAK 3 isoform X1. (579 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
LOC103073993Apoptosis-associated speck-like protein containing a CARD-like. (258 aa)
DBNLDrebrin-like protein isoform X1. (438 aa)
ESAMEndothelial cell-selective adhesion molecule isoform X1. (396 aa)
KANK4KN motif and ankyrin repeat domain-containing protein 4. (1003 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1253 aa)
VILLLOW QUALITY PROTEIN: villin-like protein. (849 aa)
FMN1Formin-1 isoform X1. (1420 aa)
TWF1Twinfilin-1 isoform X1. (357 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
TMOD4Tropomodulin-4. (345 aa)
BAIAP2Brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1. (535 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (214 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
BBS4Bardet-Biedl syndrome 4 protein. (507 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. (493 aa)
KANK3KN motif and ankyrin repeat domain-containing protein 3. (809 aa)
LOC103077822Profilin; Belongs to the profilin family. (127 aa)
VASPVasodilator-stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (384 aa)
SPTBN5LOW QUALITY PROTEIN: spectrin beta chain, non-erythrocytic 5. (3370 aa)
LOC103074616Uncharacterized protein C15orf62 homolog, mitochondrial. (175 aa)
PFN1Profilin; Belongs to the profilin family. (140 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (342 aa)
CAPZA1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
NCK1Cytoplasmic protein. (377 aa)
TMOD1Tropomodulin-1. (359 aa)
LATS1Serine/threonine-protein kinase LATS1. (1128 aa)
LMOD1Leiomodin-1. (574 aa)
SPTBN4Spectrin beta chain; Belongs to the spectrin family. (2559 aa)
ARHGAP28Rho GTPase-activating protein 28. (677 aa)
CCL11C-C motif chemokine. (99 aa)
DAAM2Disheveled-associated activator of morphogenesis 2 isoform X1. (1113 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (285 aa)
ALOX15LOW QUALITY PROTEIN: arachidonate 15-lipoxygenase. (663 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
LRRC16ALeucine-rich repeat-containing protein 16A-like isoform X1. (1372 aa)
BAIAP2L2Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2. (538 aa)
CDC42EP1Cdc42 effector protein 1. (361 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (170 aa)
GSNGelsolin isoform X1. (785 aa)
SNX9Sorting nexin-9. (680 aa)
PLEKHG2Pleckstrin homology domain-containing family G member 2. (1398 aa)
LOC103076075Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
PYCARDApoptosis-associated speck-like protein containing a CARD isoform X1. (195 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
LOC103085394Adducin-related protein 2-like. (245 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
CAPZA2F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
COTL1Coactosin-like protein. (142 aa)
DMTNDematin isoform X1. (405 aa)
ARHGAP18Rho GTPase-activating protein 18. (664 aa)
SSH3Protein phosphatase Slingshot homolog 3. (649 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (300 aa)
VIL1Villin-1. (827 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
HCLS1Hematopoietic lineage cell-specific protein isoform X1. (479 aa)
FLIIProtein flightless-1 homolog isoform X1. (1263 aa)
SSH1Protein phosphatase Slingshot homolog 1. (1039 aa)
ARPC1AActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (387 aa)
ARFGEF1Brefeldin A-inhibited guanine nucleotide-exchange protein 1. (1849 aa)
LOC103071701Protein FAM206A-like. (187 aa)
MKKSmcKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin. (570 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
RASA1Ras GTPase-activating protein 1. (1040 aa)
BAIAP2L1Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1. (492 aa)
ARPC1BActin-related protein 2/3 complex subunit; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (372 aa)
CCL21c-C motif chemokine 21. (131 aa)
RDXRadixin isoform X1. (583 aa)
TMSB10Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (42 aa)
FAM49AProtein FAM49A. (323 aa)
ADD1Alpha-adducin isoform X1. (764 aa)
PFN2Profilin; Belongs to the profilin family. (143 aa)
ADD3Gamma-adducin isoform X1. (704 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2331 aa)
FCHSD2FCH and double SH3 domains protein 2 isoform X1. (763 aa)
LOC103089567Protein translocase subunit SecA; Belongs to the SecA family. (846 aa)
HIP1RHuntingtin-interacting protein 1-related protein. (1068 aa)
SCINAdseverin. (715 aa)
FAM49BProtein FAM49B isoform X3. (324 aa)
CDC42EP3Cdc42 effector protein 3. (254 aa)
LMOD3Leiomodin-3. (564 aa)
ARF6ADP-ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
SPTA1Spectrin alpha chain, erythrocytic 1-like. (2411 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (20%) [HD]