STRINGSTRING
ITGB2 ITGB2 CAV1 CAV1 SNX1 SNX1 ACKR3 ACKR3 ADRBK1 ADRBK1 RAMP1 RAMP1 SNAP25 SNAP25 CALY CALY RAMP2 RAMP2 CLTC CLTC PICALM PICALM LOC103077771 LOC103077771 CACNG2 CACNG2 DNM3 DNM3 CALCRL CALCRL NEDD4 NEDD4 LMBRD1 LMBRD1 SYK SYK SAG SAG RAMP3 RAMP3 RAB5A RAB5A DNM1 DNM1 ITGB1 ITGB1 CACNG7 CACNG7 CD9 CD9 ACHE ACHE IL8 IL8 FCER1G FCER1G CD81 CD81 TFRC TFRC LRRTM1 LRRTM1 CAV3 CAV3 SCYL2 SCYL2 HGS HGS EZR EZR CNTN2 CNTN2 ADRBK2 ADRBK2 HTR2B HTR2B LDLRAP1 LDLRAP1 DNM2 DNM2 CACNG8 CACNG8 GRIA1 GRIA1 ARRB2 ARRB2 ARR3 ARR3 RAB31 RAB31 CACNG5 CACNG5 DRD3 DRD3 GRB2 GRB2 ARRB1 ARRB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ITGB2Integrin beta. (769 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
SNX1Sorting nexin-1 isoform X1. (522 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
ADRBK1G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (692 aa)
RAMP1Receptor activity-modifying protein 1 isoform X2. (148 aa)
SNAP25Synaptosomal-associated protein; Belongs to the SNAP-25 family. (206 aa)
CALYNeuron-specific vesicular protein calcyon. (228 aa)
RAMP2Receptor activity-modifying protein 2. (177 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1818 aa)
PICALMPhosphatidylinositol-binding clathrin assembly protein isoform X1. (652 aa)
LOC103077771E3 ubiquitin-protein ligase NEDD4-like. (515 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (323 aa)
DNM3Dynamin-3 isoform X2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (863 aa)
CALCRLCalcitonin gene-related peptide type 1 receptor; Belongs to the G-protein coupled receptor 2 family. (462 aa)
NEDD4E3 ubiquitin-protein ligase. (782 aa)
LMBRD1Probable lysosomal cobalamin transporter. (538 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
SAGS-arrestin isoform X1. (408 aa)
RAMP3Receptor activity-modifying protein 3. (147 aa)
RAB5ARas-related protein Rab-5A isoform X1. (215 aa)
DNM1Dynamin-1 isoform X3; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (864 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
CACNG7Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (275 aa)
CD9Tetraspanin. (227 aa)
ACHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (615 aa)
IL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
FCER1GHigh affinity immunoglobulin epsilon receptor subunit gamma. (87 aa)
CD81Tetraspanin. (201 aa)
TFRCTransferrin receptor protein 1 isoform X2. (770 aa)
LRRTM1Leucine-rich repeat transmembrane neuronal protein 1. (522 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
SCYL2SCY1-like protein 2. (929 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
EZREzrin isoform X1. (586 aa)
CNTN2Contactin-2. (1040 aa)
ADRBK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
LDLRAP1Low density lipoprotein receptor adapter protein 1. (309 aa)
DNM2Dynamin-2 isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (871 aa)
CACNG8Voltage-dependent calcium channel gamma-8 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (448 aa)
GRIA1Glutamate receptor 1 isoform X1. (906 aa)
ARRB2Beta-arrestin-2 isoform X1. (421 aa)
ARR3LOW QUALITY PROTEIN: arrestin-C. (393 aa)
RAB31Ras-related protein Rab-31. (205 aa)
CACNG5Voltage-dependent calcium channel gamma-5 subunit. (275 aa)
DRD3D(3) dopamine receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (400 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
ARRB1Beta-arrestin-1. (418 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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