STRINGSTRING
ENPP1 ENPP1 PCSK9 PCSK9 SLC2A8 SLC2A8 FOXO1 FOXO1 POU4F2 POU4F2 SLC27A4 SLC27A4 DNAI1 DNAI1 KAT2B KAT2B RAB10 RAB10 GOT1 GOT1 DENND4C DENND4C INHBB INHBB FOXO4 FOXO4 RARRES2 RARRES2 SH2B2 SH2B2 GPR21 GPR21 CAPN10 CAPN10 ZDHHC7 ZDHHC7 LEP LEP IGF1R IGF1R LOC103075410 LOC103075410 PARP6 PARP6 USF1 USF1 RB1 RB1 IRS1 IRS1 GHRHR GHRHR INS INS BCAR3 BCAR3 GHSR GHSR PRKCI PRKCI KL KL PTPRA PTPRA PDK2 PDK2 LPIN3 LPIN3 PARP1 PARP1 PRKDC PRKDC LOC103078777 LOC103078777 PTPN2 PTPN2 IRS4 IRS4 PPARG PPARG PHIP PHIP FER FER RHOQ RHOQ PIK3R2 PIK3R2 SLC27A1 SLC27A1 ZNF106 ZNF106 RAB8A RAB8A GSK3A GSK3A INSR INSR WDTC1 WDTC1 INSRR INSRR SLC2A4 SLC2A4 LOC103083048 LOC103083048 RPE65 RPE65 INSIG1 INSIG1 CSRP3 CSRP3 LPIN2 LPIN2 ADIPOQ ADIPOQ SMARCC1 SMARCC1 GRB10 GRB10 PTPN1 PTPN1 TBC1D4 TBC1D4 SOGA1 SOGA1 TRIB3 TRIB3 GRB14 GRB14 PCK2 PCK2 GSK3B GSK3B STXBP4 STXBP4 CAV2 CAV2 PPP1R12A PPP1R12A PDK4 PDK4 OTOP1 OTOP1 RAB15 RAB15 RPS6KB1 RPS6KB1 C2CD5 C2CD5 IRS2 IRS2 PCK1 PCK1 PIK3R3 PIK3R3 SLC39A14 SLC39A14 APC APC APPL1 APPL1 NCOA5 NCOA5 TUSC5 TUSC5 LOC103090748 LOC103090748 SYAP1 SYAP1 LOC103074205 LOC103074205 SLC25A33 SLC25A33 PDPK1 PDPK1 INPP5K INPP5K GPLD1 GPLD1 GRB2 GRB2 ZFP36L1 ZFP36L1 PIK3R1 PIK3R1 LPIN1 LPIN1 AKT1 AKT1 EPRS EPRS NDEL1 NDEL1 INSIG2 INSIG2 RAB13 RAB13 PKLR PKLR SHC1 SHC1 RAB12 RAB12 RAB31 RAB31 AKT2 AKT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
PCSK9LOW QUALITY PROTEIN: proprotein convertase subtilisin/kexin type 9. (659 aa)
SLC2A8Solute carrier family 2, facilitated glucose transporter member 8 isoform X2; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (479 aa)
FOXO1Forkhead box protein O1. (655 aa)
POU4F2POU domain protein. (408 aa)
SLC27A4Long-chain fatty acid transport protein 4. (643 aa)
DNAI1Dynein intermediate chain 1, axonemal. (697 aa)
KAT2BHistone acetyltransferase KAT2B. (735 aa)
RAB10Ras-related protein Rab-10. (200 aa)
GOT1Aspartate aminotransferase. (413 aa)
DENND4CDENN domain-containing protein 4C. (1907 aa)
INHBBInhibin beta B chain. (511 aa)
FOXO4Forkhead box protein O4 isoform X1. (512 aa)
RARRES2Retinoic acid receptor responder protein 2. (163 aa)
SH2B2SH2B adapter protein 2. (660 aa)
GPR21Probable G-protein coupled receptor 21; Belongs to the G-protein coupled receptor 1 family. (349 aa)
CAPN10Calpain-10; Belongs to the peptidase C2 family. (645 aa)
ZDHHC7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (308 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
IGF1RTyrosine-protein kinase receptor. (1367 aa)
LOC103075410Rho-related GTP-binding protein RhoQ-like. (205 aa)
PARP6Poly [ADP-ribose] polymerase. (630 aa)
USF1Upstream stimulatory factor 1 isoform X1. (310 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (452 aa)
INSInsulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
BCAR3Breast cancer anti-estrogen resistance protein 3 isoform X1. (825 aa)
GHSRGrowth hormone secretagogue receptor type 1; Belongs to the G-protein coupled receptor 1 family. (353 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
KLKlotho. (1012 aa)
PTPRAReceptor-type tyrosine-protein phosphatase alpha. (802 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
LPIN3Phosphatidate phosphatase LPIN3. (851 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1013 aa)
PRKDCDNA-dependent protein kinase catalytic subunit isoform X1; Belongs to the PI3/PI4-kinase family. (4131 aa)
LOC103078777Rho-related GTP-binding protein RhoQ-like isoform X1. (249 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type 2. (289 aa)
IRS4Insulin receptor substrate 4 isoform X1. (1267 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (505 aa)
PHIPPH-interacting protein. (1822 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (822 aa)
RHOQRho-related GTP-binding protein RhoQ. (197 aa)
PIK3R2Phosphatidylinositol 3-kinase regulatory subunit beta. (724 aa)
SLC27A1Long-chain fatty acid transport protein 1. (646 aa)
ZNF106LOW QUALITY PROTEIN: zinc finger protein 106. (1883 aa)
RAB8ARas-related protein Rab-8A. (207 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
WDTC1WD and tetratricopeptide repeats protein 1 isoform X1. (679 aa)
INSRRTyrosine-protein kinase receptor. (1301 aa)
SLC2A4Solute carrier family 2, facilitated glucose transporter member 4 isoform X1; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (550 aa)
LOC103083048Protein phosphatase 1 regulatory subunit 12A-like. (94 aa)
RPE65Retinoid isomerohydrolase. (533 aa)
INSIG1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (276 aa)
CSRP3Cysteine and glycine-rich protein 3. (194 aa)
LPIN2Phosphatidate phosphatase LPIN2 isoform X1. (917 aa)
ADIPOQC1Q and collagen domain containing adiponectin. (242 aa)
SMARCC1SWI/SNF complex subunit SMARCC1. (996 aa)
GRB10Growth factor receptor-bound protein 10 isoform X1. (588 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
TBC1D4LOW QUALITY PROTEIN: TBC1 domain family member 4. (1296 aa)
SOGA1Protein SOGA1 isoform X1. (1459 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (349 aa)
GRB14Growth factor receptor-bound protein 14 isoform X1. (540 aa)
PCK2Phosphoenolpyruvate carboxykinase [GTP], mitochondrial. (640 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
STXBP4Syntaxin-binding protein 4. (558 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PPP1R12AProtein phosphatase 1 regulatory subunit. (943 aa)
PDK4Protein-serine/threonine kinase. (407 aa)
OTOP1Otopetrin-1-like. (609 aa)
RAB15Ras-related protein Rab-15. (212 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
C2CD5C2 domain-containing protein 5 isoform X4. (1054 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
PCK1Phosphoenolpyruvate carboxykinase, cytosolic [GTP]. (622 aa)
PIK3R3LOW QUALITY PROTEIN: phosphatidylinositol 3-kinase regulatory subunit gamma. (480 aa)
SLC39A14Zinc transporter ZIP14. (523 aa)
APCAdenomatous polyposis coli protein isoform X1. (2847 aa)
APPL1DCC-interacting protein 13-alpha. (708 aa)
NCOA5Nuclear receptor coactivator 5. (579 aa)
TUSC5Tumor suppressor candidate 5 homolog. (177 aa)
LOC103090748Zinc finger protein 36, C3H1 type-like 1-like. (226 aa)
SYAP1Synapse-associated protein 1 isoform X1. (358 aa)
LOC103074205Cytoplasmic polyadenylation element-binding protein 2-like. (738 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (321 aa)
PDPK13-phosphoinositide-dependent protein kinase 1 isoform X1. (558 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (450 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (839 aa)
GRB2Growth factor receptor-bound protein 2 isoform X1. (217 aa)
ZFP36L1Zinc finger protein 36, C3H1 type-like 1-like. (338 aa)
PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alpha isoform X1. (724 aa)
LPIN1Phosphatidate phosphatase LPIN1 isoform X1. (975 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
EPRSLOW QUALITY PROTEIN: bifunctional glutamate/proline--tRNA ligase. (1519 aa)
NDEL1Nuclear distribution protein nudE-like 1 isoform X1. (345 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
RAB13Ras-related protein Rab-13. (203 aa)
PKLRPyruvate kinase; Belongs to the pyruvate kinase family. (574 aa)
SHC1SHC-transforming protein 1 isoform X1. (584 aa)
RAB12Ras-related protein Rab-12. (244 aa)
RAB31Ras-related protein Rab-31. (205 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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