STRINGSTRING
USP10 USP10 NELFA NELFA EZH2 EZH2 ELL3 ELL3 RNF8 RNF8 CDC73 CDC73 CDK12 CDK12 CTNNB1 CTNNB1 PWWP2A PWWP2A RNF168 RNF168 HNRNPU HNRNPU CDK13 CDK13 GTF2F1 GTF2F1 NELFB NELFB ELL ELL CCNT1 CCNT1 BRD4 BRD4 LOC103079308 LOC103079308 NELFE NELFE RECQL5 RECQL5 EAPP EAPP ZMYND11 ZMYND11 SUPT4H1 SUPT4H1 EAF2 EAF2 SUPT6H SUPT6H LOC103083828 LOC103083828 SUPT16H SUPT16H ELL2 ELL2 LOC103077248 LOC103077248 PWWP2B PWWP2B SHH SHH BTBD18 BTBD18 AXIN1 AXIN1 CCNK CCNK WDR43 WDR43 EAF1 EAF1 CDK9 CDK9 LEO1 LEO1 MED8 MED8 LDB1 LDB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
USP10Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (870 aa)
NELFANegative elongation factor A isoform X1. (534 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
ELL3RNA polymerase II elongation factor ELL3 isoform X2. (401 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
CDC73Parafibromin. (531 aa)
CDK12Cyclin-dependent kinase 12 isoform X1. (1490 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
PWWP2APWWP domain-containing protein 2A isoform X1. (759 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (824 aa)
CDK13Cyclin-dependent kinase 13. (1342 aa)
GTF2F1Transcription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (516 aa)
NELFBNegative elongation factor B isoform X1. (580 aa)
ELLRNA polymerase II elongation factor ELL. (613 aa)
CCNT1cyclin-T1; Belongs to the cyclin family. (727 aa)
BRD4Bromodomain-containing protein 4. (1260 aa)
LOC103079308Uncharacterized protein LOC103079308. (289 aa)
NELFENegative elongation factor E. (378 aa)
RECQL5ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (988 aa)
EAPPE2F-associated phosphoprotein. (285 aa)
ZMYND11Zinc finger MYND domain-containing protein 11 isoform X1. (445 aa)
SUPT4H1Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family. (117 aa)
EAF2ELL-associated factor 2. (264 aa)
SUPT6HTranscription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1726 aa)
LOC103083828E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (571 aa)
SUPT16HFACT complex subunit SPT16. (1047 aa)
ELL2RNA polymerase II elongation factor ELL2. (640 aa)
LOC103077248Zinc finger MYND domain-containing protein 11-like. (146 aa)
PWWP2BPWWP domain-containing protein 2B. (559 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
BTBD18BTB/POZ domain-containing protein 18. (711 aa)
AXIN1Axin-1. (866 aa)
CCNKcyclin-K; Belongs to the cyclin family. (524 aa)
WDR43WD repeat-containing protein 43. (678 aa)
EAF1ELL-associated factor 1. (268 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (372 aa)
LEO1RNA polymerase-associated protein LEO1 isoform X1. (666 aa)
MED8Mediator of RNA polymerase II transcription subunit 8; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (310 aa)
LDB1LIM domain-binding protein 1 isoform X1. (411 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.