STRINGSTRING
DUSP19 DUSP19 ADIPOQ ADIPOQ BMP4 BMP4 PDCD10 PDCD10 IL1B IL1B LRRK2 LRRK2 PTPRC PTPRC PRKCD PRKCD LOC103070679 LOC103070679 SYK SYK TPD52L1 TPD52L1 SOS1 SOS1 PTPN1 PTPN1 EDN1 EDN1 NTRK3 NTRK3 FZD4 FZD4 LAX1 LAX1 CD40 CD40 BMP7 BMP7 IRAK3 IRAK3 TRIB3 TRIB3 AJUBA AJUBA P2RX7 P2RX7 PAQR3 PAQR3 LOC103081641 LOC103081641 AGT AGT TMEM130 TMEM130 ERN2 ERN2 CBS CBS NF1 NF1 DUSP7 DUSP7 SORL1 SORL1 PDGFD PDGFD LOC103088795 LOC103088795 CAV1 CAV1 HYAL2 HYAL2 SASH1 SASH1 ADAM8 ADAM8 MAP3K13 MAP3K13 KSR1 KSR1 MAP3K7 MAP3K7 TGFA TGFA DUSP10 DUSP10 LOC103078300 LOC103078300 DUSP1 DUSP1 SPRY2 SPRY2 SH2B3 SH2B3 SFRP2 SFRP2 DRD4 DRD4 LOC103088508 LOC103088508 CDK12 CDK12 SPRY3 SPRY3 PDGFA PDGFA FGF18 FGF18 EPHA4 EPHA4 ARHGEF5 ARHGEF5 HRAS HRAS DAB2IP DAB2IP SPRY4 SPRY4 FGF1 FGF1 FGD2 FGD2 EZH2 EZH2 LOC103069061 LOC103069061 ADAM9 ADAM9 TNFSF11 TNFSF11 FGF2 FGF2 DVL3 DVL3 ADRA2A ADRA2A BMP2 BMP2 FGFR1 FGFR1 SPRY1 SPRY1 DUSP16 DUSP16 PTPN6 PTPN6 FZD10 FZD10 LOC103072107 LOC103072107 CCL19 CCL19 FLT1 FLT1 LOC103070824 LOC103070824 PIK3CG PIK3CG AXIN1 AXIN1 PTPRJ PTPRJ TAOK3 TAOK3 PDGFB PDGFB INPP5K INPP5K NEK10 NEK10 CD300A CD300A LOC103085427 LOC103085427 ROBO1 ROBO1 RPS3 RPS3 PIK3R6 PIK3R6 SFRP1 SFRP1 ERN1 ERN1 WNT5A WNT5A TRIB1 TRIB1 KIT KIT IRAK1 IRAK1 MAP3K4 MAP3K4 TRIB2 TRIB2 AGER AGER TNXB TNXB SMPD1 SMPD1 TNFRSF11A TNFRSF11A DVL2 DVL2 PIK3R5 PIK3R5 GBA GBA RASGRP1 RASGRP1 INSR INSR MAP3K10 MAP3K10 TGFB1 TGFB1 PSEN1 PSEN1 CBLC CBLC TRAF2 TRAF2 DTNBP1 DTNBP1 THBS1 THBS1 NOD2 NOD2 LOC103080512 LOC103080512 MAP4K2 MAP4K2 HTR2B HTR2B PAK1 PAK1 IL34 IL34 RGS14 RGS14 NUP62 NUP62 LOC103069302 LOC103069302 HMGCR HMGCR FZD5 FZD5 EGFR EGFR NOX4 NOX4 MAP3K11 MAP3K11 PDGFC PDGFC HGS HGS EPGN EPGN ERBB2 ERBB2 LYN LYN EGF EGF CAV3 CAV3 TSG101 TSG101 CDK5RAP3 CDK5RAP3 MST1R MST1R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DUSP19Dual specificity protein phosphatase 19; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (226 aa)
ADIPOQC1Q and collagen domain containing adiponectin. (242 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
PDCD10Programmed cell death protein 10 isoform X1. (212 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2-like. (920 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1121 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
LOC103070679Cysteine synthase-like. (284 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
TPD52L1LOW QUALITY PROTEIN: tumor protein D53. (269 aa)
SOS1Son of sevenless homolog 1. (1333 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
EDN1Endothelin-1. (202 aa)
NTRK3Tyrosine-protein kinase receptor. (839 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
LAX1LOW QUALITY PROTEIN: lymphocyte transmembrane adapter 1. (430 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
IRAK3Interleukin-1 receptor-associated kinase 3. (590 aa)
TRIB3LOW QUALITY PROTEIN: tribbles homolog 3. (349 aa)
AJUBALIM domain-containing protein ajuba. (557 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
PAQR3Progestin and adipoQ receptor family member 3. (311 aa)
LOC103081641LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
TMEM130Transmembrane protein 130 isoform X1. (435 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (924 aa)
CBSCystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (477 aa)
NF1Neurofibromin isoform X1. (2841 aa)
DUSP7Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (419 aa)
SORL1Sortilin-related receptor. (2211 aa)
PDGFDPlatelet-derived growth factor D-like isoform X1. (370 aa)
LOC103088795TNF receptor-associated factor 6-like. (315 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
HYAL2Hyaluronidase. (476 aa)
SASH1SAM and SH3 domain-containing protein 1. (1235 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (1009 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (968 aa)
KSR1Kinase suppressor of Ras 1. (757 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
TGFAProtransforming growth factor alpha. (145 aa)
DUSP10Dual specificity protein phosphatase 10 isoform X1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (483 aa)
LOC103078300Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (324 aa)
DUSP1Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (367 aa)
SPRY2Protein sprouty homolog 2 isoform X1. (315 aa)
SH2B3SH2B adapter protein 3. (573 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
DRD4LOW QUALITY PROTEIN: D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
LOC103088508TNF receptor-associated factor 6-like. (251 aa)
CDK12Cyclin-dependent kinase 12 isoform X1. (1490 aa)
SPRY3Protein sprouty homolog 3. (288 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
EPHA4Ephrin type-A receptor 4-like isoform X1. (986 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1576 aa)
HRASGTPase HRas isoform X1. (189 aa)
DAB2IPLOW QUALITY PROTEIN: disabled homolog 2-interacting protein. (1173 aa)
SPRY4Protein sprouty homolog 4. (299 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
FGD2FYVE, RhoGEF and PH domain-containing protein 2. (551 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
LOC103069061Mitogen-activated protein kinase kinase kinase 5-like. (127 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9. (819 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
ADRA2Aalpha-2A adrenergic receptor. (462 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
DUSP16Dual specificity protein phosphatase 16. (647 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FZD10LOW QUALITY PROTEIN: frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
LOC10307210740S ribosomal protein S3-like; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CCL19C-C motif chemokine. (100 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
LOC103070824Leucine-rich repeat serine/threonine-protein kinase 2-like. (1609 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1126 aa)
AXIN1Axin-1. (866 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta-like. (1155 aa)
TAOK3Serine/threonine-protein kinase TAO3 isoform X1. (898 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
INPP5KInositol polyphosphate 5-phosphatase K isoform X1. (450 aa)
NEK10Serine/threonine-protein kinase Nek10. (1173 aa)
CD300ACMRF35-like molecule 8. (303 aa)
LOC103085427Nuclear pore glycoprotein p62-like. (328 aa)
ROBO1Roundabout homolog 1-like isoform X1. (1652 aa)
RPS340S ribosomal protein S3 isoform X3; Belongs to the universal ribosomal protein uS3 family. (254 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
ERN1LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1. (1251 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
TRIB1Tribbles homolog 1. (372 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (732 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1644 aa)
TRIB2Tribbles homolog 2 isoform X1. (343 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (421 aa)
TNXBLOW QUALITY PROTEIN: tenascin-X. (3938 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (850 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (873 aa)
GBAGlucosylceramidase. (536 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (948 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
CBLCE3 ubiquitin-protein ligase CBL-C. (492 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
DTNBP1Dysbindin. (341 aa)
THBS1Thrombospondin-1. (1170 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
LOC103080512FYVE, RhoGEF and PH domain-containing protein 2-like. (213 aa)
MAP4K2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (842 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
PAK1Non-specific serine/threonine protein kinase. (563 aa)
IL34LOW QUALITY PROTEIN: interleukin-34. (268 aa)
RGS14Regulator of G-protein signaling 14. (567 aa)
NUP62Nuclear pore glycoprotein p62. (516 aa)
LOC103069302Uncharacterized protein LOC103069302. (292 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (858 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate; Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin- coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (E [...] (777 aa)
EPGNEpigen isoform X1. (153 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LYNTyrosine-protein kinase. (516 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
TSG101Tumor susceptibility gene 101 protein. (391 aa)
CDK5RAP3CDK5 regulatory subunit-associated protein 3. (505 aa)
MST1RMacrophage-stimulating protein receptor. (1382 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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