STRINGSTRING
P2RX7 P2RX7 TGFB1 TGFB1 PSEN1 PSEN1 TRAF2 TRAF2 THBS1 THBS1 NOD2 NOD2 LOC103080512 LOC103080512 MAP4K2 MAP4K2 HTR2B HTR2B PAK1 PAK1 IL34 IL34 FZD5 FZD5 EGFR EGFR NOX4 NOX4 MAP3K11 MAP3K11 PDGFC PDGFC PIK3CG PIK3CG AXIN1 AXIN1 TAOK3 TAOK3 PDGFB PDGFB NEK10 NEK10 ROBO1 ROBO1 RPS3 RPS3 IL1B IL1B IRAK1 IRAK1 MAP3K4 MAP3K4 AGER AGER TNFRSF11A TNFRSF11A DVL2 DVL2 PIK3R5 PIK3R5 RASGRP1 RASGRP1 INSR INSR EPGN EPGN ERBB2 ERBB2 EGF EGF MST1R MST1R DRD4 DRD4 LOC103088508 LOC103088508 PDGFA PDGFA FGF18 FGF18 EPHA4 EPHA4 ARHGEF5 ARHGEF5 HRAS HRAS DAB2IP DAB2IP FGF1 FGF1 FGD2 FGD2 EZH2 EZH2 PIK3R6 PIK3R6 ERN1 ERN1 WNT5A WNT5A KIT KIT LOC103069061 LOC103069061 ADAM9 ADAM9 TNFSF11 TNFSF11 FGF2 FGF2 DVL3 DVL3 ADRA2A ADRA2A FGFR1 FGFR1 FZD10 FZD10 LOC103072107 LOC103072107 CCL19 CCL19 FLT1 FLT1 LOC103070824 LOC103070824 TGFA TGFA MAP3K7 MAP3K7 MAP3K13 MAP3K13 ADAM8 ADAM8 SASH1 SASH1 LOC103088795 LOC103088795 PDGFD PDGFD ERN2 ERN2 LOC103081641 LOC103081641 MAP3K10 MAP3K10 AJUBA AJUBA CD40 CD40 FZD4 FZD4 NTRK3 NTRK3 EDN1 EDN1 PTPN1 PTPN1 TPD52L1 TPD52L1 SYK SYK PTPRC PTPRC LRRK2 LRRK2 PDCD10 PDCD10
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
THBS1Thrombospondin-1. (1170 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
LOC103080512FYVE, RhoGEF and PH domain-containing protein 2-like. (213 aa)
MAP4K2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (842 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
PAK1Non-specific serine/threonine protein kinase. (563 aa)
IL34LOW QUALITY PROTEIN: interleukin-34. (268 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (858 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1126 aa)
AXIN1Axin-1. (866 aa)
TAOK3Serine/threonine-protein kinase TAO3 isoform X1. (898 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
NEK10Serine/threonine-protein kinase Nek10. (1173 aa)
ROBO1Roundabout homolog 1-like isoform X1. (1652 aa)
RPS340S ribosomal protein S3 isoform X3; Belongs to the universal ribosomal protein uS3 family. (254 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (732 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1644 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (421 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (850 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (873 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
EPGNEpigen isoform X1. (153 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
MST1RMacrophage-stimulating protein receptor. (1382 aa)
DRD4LOW QUALITY PROTEIN: D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
LOC103088508TNF receptor-associated factor 6-like. (251 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
EPHA4Ephrin type-A receptor 4-like isoform X1. (986 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1576 aa)
HRASGTPase HRas isoform X1. (189 aa)
DAB2IPLOW QUALITY PROTEIN: disabled homolog 2-interacting protein. (1173 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
FGD2FYVE, RhoGEF and PH domain-containing protein 2. (551 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
ERN1LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1. (1251 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
LOC103069061Mitogen-activated protein kinase kinase kinase 5-like. (127 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9. (819 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
ADRA2Aalpha-2A adrenergic receptor. (462 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
FZD10LOW QUALITY PROTEIN: frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
LOC10307210740S ribosomal protein S3-like; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CCL19C-C motif chemokine. (100 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
LOC103070824Leucine-rich repeat serine/threonine-protein kinase 2-like. (1609 aa)
TGFAProtransforming growth factor alpha. (145 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (968 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (1009 aa)
SASH1SAM and SH3 domain-containing protein 1. (1235 aa)
LOC103088795TNF receptor-associated factor 6-like. (315 aa)
PDGFDPlatelet-derived growth factor D-like isoform X1. (370 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (924 aa)
LOC103081641LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (948 aa)
AJUBALIM domain-containing protein ajuba. (557 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
NTRK3Tyrosine-protein kinase receptor. (839 aa)
EDN1Endothelin-1. (202 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
TPD52L1LOW QUALITY PROTEIN: tumor protein D53. (269 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1121 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2-like. (920 aa)
PDCD10Programmed cell death protein 10 isoform X1. (212 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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