STRINGSTRING
APP APP GDF11 GDF11 TLX3 TLX3 CALR CALR HMG20A HMG20A GLI3 GLI3 ZNF536 ZNF536 LBX1 LBX1 TTC3 TTC3 CNTN2 CNTN2 ISL1 ISL1 REST REST POU4F2 POU4F2 ITGB1 ITGB1 JAG1 JAG1 HEY1 HEY1 DLX6 DLX6 CDK5RAP2 CDK5RAP2 CTDSP1 CTDSP1 ASCL1 ASCL1 SOX9 SOX9 NKX2-2 NKX2-2 EIF4ENIF1 EIF4ENIF1 HES3 HES3 SOX8 SOX8 GPR37L1 GPR37L1 FEZF2 FEZF2 WNT3A WNT3A SHH SHH CNTF CNTF LOC103090669 LOC103090669 DDX6 DDX6 DLX2 DLX2 HES1 HES1 IRX3 IRX3 LOC103079308 LOC103079308 LMX1A LMX1A LOC103081687 LOC103081687 PAX6 PAX6 DLX1 DLX1 NOTCH1 NOTCH1 ISL2 ISL2 PTCHD2 PTCHD2 MEIS1 MEIS1 MED1 MED1 LOC103073063 LOC103073063 EIF4E EIF4E HOXA2 HOXA2 DIXDC1 DIXDC1 OLIG2 OLIG2 DLL1 DLL1 LSM1 LSM1 NR2E1 NR2E1 BMP7 BMP7 MIB1 MIB1 CNTN4 CNTN4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APPAmyloid beta A4 protein isoform X1. (767 aa)
GDF11Growth/differentiation factor 11. (404 aa)
TLX3T-cell leukemia homeobox protein 3. (291 aa)
CALRCalreticulin. (415 aa)
HMG20AHigh mobility group protein 20A. (347 aa)
GLI3Transcriptional activator GLI3. (1590 aa)
ZNF536Zinc finger protein 536. (1300 aa)
LBX1Transcription factor LBX1. (280 aa)
TTC3E3 ubiquitin-protein ligase TTC3. (1991 aa)
CNTN2Contactin-2. (1040 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
RESTRE1-silencing transcription factor-like isoform X1. (1002 aa)
POU4F2POU domain protein. (408 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
HEY1Hairy/enhancer-of-split related with YRPW motif protein 1 isoform X1. (308 aa)
DLX6Homeobox protein Dlx6a. (286 aa)
CDK5RAP2CDK5 regulatory subunit-associated protein 2 isoform X1. (1900 aa)
CTDSP1Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1. (214 aa)
ASCL1Achaete-scute homolog 1. (227 aa)
SOX9Transcription factor SOX-9 isoform X1. (509 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E transporter isoform X1. (982 aa)
HES3Transcription factor HES-3. (203 aa)
SOX8Transcription factor SOX-8. (463 aa)
GPR37L1Prosaposin receptor GPR37L1. (463 aa)
FEZF2Fez family zinc finger protein 2. (461 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
CNTFCiliary neurotrophic factor. (200 aa)
LOC103090669RE1-silencing transcription factor-like isoform X1. (986 aa)
DDX6Probable ATP-dependent RNA helicase DDX6; Belongs to the DEAD box helicase family. (483 aa)
DLX2LOW QUALITY PROTEIN: homeobox protein DLX-2. (335 aa)
HES1Transcription factor HES-1. (280 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (503 aa)
LOC103079308Uncharacterized protein LOC103079308. (289 aa)
LMX1ALIM homeobox transcription factor 1-alpha isoform X1. (382 aa)
LOC103081687Uncharacterized protein C3orf17 homolog isoform X1. (563 aa)
PAX6Paired box protein Pax-6 isoform X1. (436 aa)
DLX1Homeobox protein DLX-1. (255 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
ISL2Insulin gene enhancer protein ISL-2. (359 aa)
PTCHD2Patched domain-containing protein 2 isoform X1. (1391 aa)
MEIS1Homeobox protein Meis2 isoform X1. (475 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
LOC103073063Forkhead box protein G1-like isoform X1. (483 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (230 aa)
HOXA2Homeobox protein Hox-A2. (372 aa)
DIXDC1Dixin isoform X1. (679 aa)
OLIG2Oligodendrocyte transcription factor 2. (270 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (721 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
MIB1E3 ubiquitin-protein ligase MIB1. (1006 aa)
CNTN4Contactin-4. (990 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.