STRINGSTRING
TP53 TP53 PSRC1 PSRC1 GJA1 GJA1 HIF1A HIF1A TGFB2 TGFB2 SEMA4G SEMA4G SEMA4C SEMA4C SEMA4B SEMA4B LOC103072643 LOC103072643 NAIF1 NAIF1 CDKN1B CDKN1B DCBLD2 DCBLD2 CDK5 CDK5 ADRB1 ADRB1 TBX5 TBX5 OSTN OSTN SOCS2 SOCS2 MYOZ1 MYOZ1 CDKN1A CDKN1A ING4 ING4 BMPR2 BMPR2 MYL10 MYL10 CDKN2AIP CDKN2AIP INHBA INHBA RB1 RB1 DCUN1D3 DCUN1D3 SEMA3F SEMA3F LOC103084276 LOC103084276 MYL2 MYL2 SMARCA2 SMARCA2 PNPT1 PNPT1 WWC2 WWC2 RTN4 RTN4 PI16 PI16 WNT3 WNT3 PHB PHB SEMA3B SEMA3B MSTN MSTN FXN FXN SFRP2 SFRP2 SEMA3C SEMA3C STK4 STK4 TP53TG5 TP53TG5 MSX1 MSX1 SLIT2 SLIT2 DUSP10 DUSP10 SH3BP4 SH3BP4 SMAD4 SMAD4 PPP1R9B PPP1R9B SPHK2 SPHK2 NOG NOG ULK1 ULK1 SEMA3A SEMA3A BCL2 BCL2 HNF4A HNF4A EPHA7 EPHA7 SPG20 SPG20 BMP10 BMP10 SOX17 SOX17 FHL1 FHL1 GPC3 GPC3 SEMA3D SEMA3D SEMA5A SEMA5A FSTL4 FSTL4 YJEFN3 YJEFN3 WWC3 WWC3 DRAXIN DRAXIN CDHR2 CDHR2 SESN2 SESN2 GNB2L1 GNB2L1 STK11 STK11 PTPRS PTPRS LOC103083694 LOC103083694 JARID2 JARID2 GREM1 GREM1 GDF15 GDF15 RTN4R RTN4R CDKN2C CDKN2C CDKN2D CDKN2D CCDC85B CCDC85B WNT11 WNT11 CIRBP CIRBP MUL1 MUL1 BBS2 BBS2 SERPINE2 SERPINE2 CDKL3 CDKL3 GDF9 GDF9 NDUFA13 NDUFA13 TGFB1 TGFB1 WT1 WT1 NKD1 NKD1 LOC103070111 LOC103070111 SEMA4F SEMA4F SEMA6B SEMA6B GSK3A GSK3A SMARCA4 SMARCA4 ADAM15 ADAM15 NTN1 NTN1 SEMA6C SEMA6C SERTAD1 SERTAD1 PLXNA3 PLXNA3 LOC103069839 LOC103069839 LOC103070640 LOC103070640 STK3 STK3 LOC103073513 LOC103073513 SEMA4A SEMA4A LOC103075570 LOC103075570 ALOX15B ALOX15B ST7L ST7L RYK RYK SIRT1 SIRT1 ENPP1 ENPP1 LOC103080593 LOC103080593 SERTAD3 SERTAD3 DDX3X DDX3X BBC3 BBC3 WNT5A WNT5A KIAA1024 KIAA1024 SFRP1 SFRP1 SEMA3E SEMA3E TSPYL2 TSPYL2 LGMN LGMN RBBP7 RBBP7 WNT3A WNT3A TLL2 TLL2 RERG RERG KIAA0319 KIAA0319 PTPRJ PTPRJ FRZB FRZB NDUFS3 NDUFS3 GDF2 GDF2 CRLF3 CRLF3 ACVR1B ACVR1B GNG4 GNG4 CAPRIN2 CAPRIN2 SEMA3G SEMA3G NOV NOV SLC6A4 SLC6A4 MAPK11 MAPK11 HYAL1 HYAL1 DIP2B DIP2B HYAL2 HYAL2 ENO1 ENO1 TNR TNR ACVRL1 ACVRL1 LOC103079656 LOC103079656 HRG HRG OSGIN1 OSGIN1 CCAR2 CCAR2 IFRD2 IFRD2 LOC103085385 LOC103085385 LOC103078443 LOC103078443 ST7 ST7 SEMA6A SEMA6A BCL6 BCL6 RAI1 RAI1 PTCH1 PTCH1 EAF2 EAF2 FLCN FLCN ADRB3 ADRB3 LOC103085370 LOC103085370 SLIT3 SLIT3 TP73 TP73 SEMA5B SEMA5B LOC103073178 LOC103073178 PML PML SAV1 SAV1 FBP1 FBP1 SMAD3 SMAD3 DCSTAMP DCSTAMP IP6K2 IP6K2 LOC103083351 LOC103083351 ADRB2 ADRB2 SEMA4D SEMA4D WWC1 WWC1 OSGIN2 OSGIN2 CGRRF1 CGRRF1 SEMA7A SEMA7A NME6 NME6 BMP4 BMP4 DNAJB2 DNAJB2 SERTAD2 SERTAD2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (387 aa)
PSRC1LOW QUALITY PROTEIN: proline/serine-rich coiled-coil 1. (310 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (383 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (822 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (843 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
SEMA4Bsemaphorin-4B; Belongs to the semaphorin family. (822 aa)
LOC103072643Frataxin, mitochondrial-like. (197 aa)
NAIF1Nuclear apoptosis-inducing factor 1. (327 aa)
CDKN1BCyclin-dependent kinase inhibitor 1B. (198 aa)
DCBLD2Discoidin, CUB and LCCL domain-containing protein 2 isoform X1. (780 aa)
CDK5Cyclin-dependent kinase 5 isoform X1; Belongs to the protein kinase superfamily. (292 aa)
ADRB1Beta-1 adrenergic receptor. (465 aa)
TBX5T-box transcription factor TBX5 isoform X1. (519 aa)
OSTNOsteocrin. (132 aa)
SOCS2Suppressor of cytokine signaling 2 isoform X1. (198 aa)
MYOZ1Myozenin-1. (298 aa)
CDKN1ACyclin-dependent kinase inhibitor 1 isoform X1. (164 aa)
ING4Inhibitor of growth protein. (249 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
MYL10Myosin regulatory light chain 10. (147 aa)
CDKN2AIPCDKN2A-interacting protein. (573 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (430 aa)
RB1Retinoblastoma-associated protein isoform X1. (929 aa)
DCUN1D3DCN1-like protein. (304 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
LOC10308427625-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial-like; Belongs to the cytochrome P450 family. (507 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
SMARCA2Probable global transcription activator SNF2L2-like isoform X1. (1559 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1, mitochondrial. (784 aa)
WWC2Protein WWC2. (1193 aa)
RTN4Reticulon. (1187 aa)
PI16Peptidase inhibitor 16 isoform X1; Belongs to the CRISP family. (460 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
PHBProhibitin. (297 aa)
SEMA3Bsemaphorin-3B isoform X3; Belongs to the semaphorin family. (753 aa)
MSTNGrowth/differentiation factor 8. (366 aa)
FXNFrataxin, mitochondrial. (215 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
TP53TG5TP53-target gene 5 protein. (286 aa)
MSX1Homeobox protein MSX-1. (303 aa)
SLIT2LOW QUALITY PROTEIN: slit homolog 2 protein. (1521 aa)
DUSP10Dual specificity protein phosphatase 10 isoform X1; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (483 aa)
SH3BP4SH3 domain-binding protein 4. (959 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
PPP1R9BNeurabin-2. (718 aa)
SPHK2Sphingosine kinase 2 isoform X1. (655 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ULK1Serine/threonine-protein kinase ULK1. (1055 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (474 aa)
EPHA7Ephrin type-A receptor 7-like isoform X1. (998 aa)
SPG20Spartin isoform X1. (668 aa)
BMP10Bone morphogenetic protein 10. (421 aa)
SOX17Transcription factor SOX-17. (405 aa)
FHL1Four and a half LIM domains protein 1 isoform X1. (339 aa)
GPC3Glypican-3 isoform X1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (777 aa)
SEMA5Asemaphorin-5A. (1073 aa)
FSTL4Follistatin-related protein 4. (844 aa)
YJEFN3yjeF N-terminal domain-containing protein 3. (268 aa)
WWC3Protein WWC3. (1097 aa)
DRAXINDraxin; Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway. (349 aa)
CDHR2Cadherin-related family member 2. (1305 aa)
SESN2Sestrin-2 isoform X1. (480 aa)
GNB2L1Guanine nucleotide-binding protein subunit beta-2-like 1. (317 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (438 aa)
PTPRSReceptor-type tyrosine-protein phosphatase S isoform X2. (1948 aa)
LOC103083694Cytochrome P450 27C1-like; Belongs to the cytochrome P450 family. (469 aa)
JARID2LOW QUALITY PROTEIN: protein Jumonji. (1237 aa)
GREM1Gremlin. (184 aa)
GDF15Growth/differentiation factor 15. (308 aa)
RTN4RReticulon-4 receptor. (831 aa)
CDKN2CCyclin-dependent kinase 4 inhibitor C. (168 aa)
CDKN2DCyclin-dependent kinase 4 inhibitor D. (166 aa)
CCDC85BCoiled-coil domain-containing protein 85B. (202 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
CIRBPCold-inducible RNA-binding protein. (172 aa)
MUL1Mitochondrial ubiquitin ligase activator of NFKB 1. (352 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
SERPINE2Glia-derived nexin isoform X2; Belongs to the serpin family. (398 aa)
CDKL3LOW QUALITY PROTEIN: cyclin-dependent kinase-like 3. (584 aa)
GDF9Growth/differentiation factor 9. (454 aa)
NDUFA13NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13. (144 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
WT1Wilms tumor protein isoform X1. (450 aa)
NKD1Protein naked cuticle homolog 1. (471 aa)
LOC103070111Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
SEMA4Fsemaphorin-4F; Belongs to the semaphorin family. (777 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (812 aa)
GSK3AGlycogen synthase kinase-3 alpha; Belongs to the protein kinase superfamily. (483 aa)
SMARCA4Transcription activator BRG1. (1619 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (866 aa)
NTN1Netrin-1 isoform X1. (604 aa)
SEMA6Csemaphorin-6C isoform X1; Belongs to the semaphorin family. (966 aa)
SERTAD1SERTA domain-containing protein 1. (238 aa)
PLXNA3plexin-A3. (1873 aa)
LOC103069839Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
LOC103070640Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
STK3Serine/threonine-protein kinase 3 isoform X1. (491 aa)
LOC103073513Testis-specific Y-encoded-like protein 5-like; Belongs to the nucleosome assembly protein (NAP) family. (418 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
LOC103075570Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
ALOX15BArachidonate 15-lipoxygenase B. (659 aa)
ST7LSuppressor of tumorigenicity 7 protein-like isoform X1. (588 aa)
RYKTyrosine-protein kinase RYK. (475 aa)
SIRT1LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1. (695 aa)
ENPP1Ectonucleotide pyrophosphatase/phosphodiesterase family member 1. (925 aa)
LOC103080593SERTA domain-containing protein 1-like. (238 aa)
SERTAD3SERTA domain-containing protein 3. (198 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
BBC3Bcl-2-binding component 3. (193 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KIAA1024UPF0258 protein KIAA1024 homolog. (918 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SEMA3Esemaphorin-3E-like; Belongs to the semaphorin family. (715 aa)
TSPYL2LOW QUALITY PROTEIN: testis-specific Y-encoded-like protein 2; Belongs to the nucleosome assembly protein (NAP) family. (740 aa)
LGMNLegumain. (434 aa)
RBBP7Histone-binding protein RBBP7 isoform X1. (469 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TLL2Metalloendopeptidase. (1020 aa)
RERGRas-related and estrogen-regulated growth inhibitor isoform X1. (199 aa)
KIAA0319Dyslexia-associated protein KIAA0319 homolog isoform X2. (1083 aa)
PTPRJReceptor-type tyrosine-protein phosphatase eta-like. (1155 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
NDUFS3NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial; Belongs to the complex I 30 kDa subunit family. (266 aa)
GDF2Growth/differentiation factor 2. (431 aa)
CRLF3Cytokine receptor-like factor 3. (438 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (494 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
CAPRIN2Caprin-2 isoform X1. (1070 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (772 aa)
NOVProtein NOV homolog isoform X1. (358 aa)
SLC6A4Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (630 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
HYAL1Hyaluronidase. (431 aa)
DIP2BDisco-interacting protein 2 homolog B. (1576 aa)
HYAL2Hyaluronidase. (476 aa)
ENO1Alpha-enolase isoform X2. (434 aa)
TNRtenascin-R. (1358 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (514 aa)
LOC103079656Metallothionein; Metallothioneins have a high content of cysteine residues that bind various heavy metals. (61 aa)
HRGLOW QUALITY PROTEIN: histidine-rich glycoprotein. (472 aa)
OSGIN1Oxidative stress-induced growth inhibitor 1. (478 aa)
CCAR2LOW QUALITY PROTEIN: cell cycle and apoptosis regulator protein 2. (918 aa)
IFRD2Interferon-related developmental regulator 2. (441 aa)
LOC103085385Neuroendocrine secretory protein 55-like. (242 aa)
LOC103078443Centrosomal protein C10orf90 homolog. (695 aa)
ST7Suppressor of tumorigenicity 7 protein isoform X1. (585 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
BCL6B-cell lymphoma 6 protein isoform X1. (728 aa)
RAI1Retinoic acid-induced protein 1. (2042 aa)
PTCH1Protein patched homolog 1 isoform X1. (1448 aa)
EAF2ELL-associated factor 2. (264 aa)
FLCNFolliculin. (579 aa)
ADRB3LOW QUALITY PROTEIN: beta-3 adrenergic receptor; Belongs to the G-protein coupled receptor 1 family. (375 aa)
LOC103085370Placenta-specific gene 8 protein-like. (113 aa)
SLIT3Slit homolog 3 protein. (1523 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (638 aa)
SEMA5Bsemaphorin-5B isoform X1. (1093 aa)
LOC103073178Fructose-1,6-bisphosphatase, cytosolic-like; Belongs to the FBPase class 1 family. (281 aa)
PMLProtein PML. (848 aa)
SAV1Protein salvador homolog 1. (384 aa)
FBP1Fructose-1,6-bisphosphatase 1; Belongs to the FBPase class 1 family. (338 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
DCSTAMPDendritic cell-specific transmembrane protein isoform X1. (470 aa)
IP6K2Kinase; Belongs to the inositol phosphokinase (IPK) family. (425 aa)
LOC103083351LOW QUALITY PROTEIN: semaphorin-6D-like; Belongs to the semaphorin family. (1131 aa)
ADRB2Beta-2 adrenergic receptor. (419 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
WWC1Protein KIBRA. (1110 aa)
OSGIN2Oxidative stress-induced growth inhibitor 2. (551 aa)
CGRRF1Cell growth regulator with RING finger domain protein 1. (332 aa)
SEMA7Asemaphorin-7A isoform X1; Belongs to the semaphorin family. (663 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
DNAJB2dnaJ homolog subfamily B member 2 isoform X1. (325 aa)
SERTAD2SERTA domain-containing protein 2. (311 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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