STRINGSTRING
REST REST FFAR3 FFAR3 HFE HFE CRHBP CRHBP INHBB INHBB REN REN RBP4 RBP4 NKX6-1 NKX6-1 LOC103087151 LOC103087151 CREB1 CREB1 VAMP8 VAMP8 LOC103083735 LOC103083735 FFAR1 FFAR1 PTPN11 PTPN11 ADRA2A ADRA2A UCN UCN CAPN10 CAPN10 NMB NMB TNFSF11 TNFSF11 LEP LEP KLF7 KLF7 PASK PASK LOC103075895 LOC103075895 SLC8B1 SLC8B1 LOC103080655 LOC103080655 TCF7L2 TCF7L2 SLC25A18 SLC25A18 IL11 IL11 TFR2 TFR2 INHBA INHBA IRS1 IRS1 GHRHR GHRHR C1QTNF3 C1QTNF3 NPVF NPVF SCT SCT SLC25A22 SLC25A22 ANO1 ANO1 GIP GIP GPER1 GPER1 GCG GCG VSNL1 VSNL1 SMAD4 SMAD4 NR1H4 NR1H4 NR1D1 NR1D1 LOC103090855 LOC103090855 CRY1 CRY1 HNF4A HNF4A LOC103088397 LOC103088397 SCG5 SCG5 SLC9B2 SLC9B2 BAD BAD LOC103090072 LOC103090072 IFNG IFNG LOC103071669 LOC103071669 BIRC5 BIRC5 C1QTNF1 C1QTNF1 OSM OSM LIF LIF SYT9 SYT9 CELA2A CELA2A PRKCE PRKCE KCNJ11 KCNJ11 LOC103070650 LOC103070650 MIDN MIDN CDV3 CDV3 PARK2 PARK2 MPC2 MPC2 ADCYAP1 ADCYAP1 HMGN3 HMGN3 C2CD2L C2CD2L NKX3-1 NKX3-1 LOC103090669 LOC103090669 KDM5B KDM5B LOC103085888 LOC103085888 CRY2 CRY2 SFRP1 SFRP1 POMC POMC FKBP1B FKBP1B ANXA1 ANXA1 GPLD1 GPLD1 RPH3AL RPH3AL DOC2B DOC2B PPP3CB PPP3CB ARHGEF7 ARHGEF7 SOX4 SOX4 EFNA5 EFNA5 MCU MCU NDUFAF2 NDUFAF2 RFX6 RFX6 CHGA CHGA DRD2 DRD2 PASD1 PASD1 C1QTNF6 C1QTNF6 PLA2G6 PLA2G6 GHRL GHRL PICK1 PICK1 RAB11FIP3 RAB11FIP3 SSTR5 SSTR5 BAIAP3 BAIAP3 PLA2G3 PLA2G3 CDK16 CDK16 PFKL PFKL STXBP5L STXBP5L NOS2 NOS2 ILDR1 ILDR1 LOC103068503 LOC103068503 CLOCK CLOCK TFAP2B TFAP2B GALR1 GALR1 FGB FGB GRP GRP IRS2 IRS2 ADCY5 ADCY5 CFTR CFTR RAB11FIP1 RAB11FIP1 SPP1 SPP1 PAX8 PAX8 IL1B IL1B ACVR1C ACVR1C NNAT NNAT HTR1A HTR1A EDN1 EDN1 CRH CRH SNX4 SNX4 GPR27 GPR27 AACS AACS SRI SRI TM7SF3 TM7SF3 KCNB1 KCNB1 CCL5 CCL5 ALOX5 ALOX5 SIDT2 SIDT2 RASL10B RASL10B GCK GCK CCKAR CCKAR FAM132A FAM132A IL6 IL6 TMF1 TMF1 GHRH GHRH ICA1 ICA1 LRP5 LRP5 TCIRG1 TCIRG1 ADCY8 ADCY8 STXBP4 STXBP4 SIRT4 SIRT4 HNF1A HNF1A GPR68 GPR68 PDX1 PDX1 LRRC8A LRRC8A GJA1 GJA1 HIF1A HIF1A FOXO1 FOXO1 BLK BLK CHD7 CHD7 FFAR4 FFAR4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RESTRE1-silencing transcription factor-like isoform X1. (1002 aa)
FFAR3LOW QUALITY PROTEIN: free fatty acid receptor 3. (302 aa)
HFEHereditary hemochromatosis protein homolog isoform X1; Belongs to the MHC class I family. (356 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (322 aa)
INHBBInhibin beta B chain. (511 aa)
RENRenin isoform X1; Belongs to the peptidase A1 family. (407 aa)
RBP4Retinol-binding protein; Retinol-binding protein that mediates retinol transport in blood plasma. (200 aa)
NKX6-1Homeobox protein Nkx-6.1-like. (365 aa)
LOC103087151Uncharacterized protein LOC103087151. (457 aa)
CREB1Cyclic AMP-responsive element-binding protein 1. (293 aa)
VAMP8Vesicle-associated membrane protein 8. (99 aa)
LOC103083735E3 ubiquitin-protein ligase parkin-like. (141 aa)
FFAR1Free fatty acid receptor 1. (300 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
ADRA2Aalpha-2A adrenergic receptor. (462 aa)
UCNUrocortin. (126 aa)
CAPN10Calpain-10; Belongs to the peptidase C2 family. (645 aa)
NMBneuromedin-B. (137 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (167 aa)
KLF7Krueppel-like factor 7. (302 aa)
PASKPAS domain-containing serine/threonine-protein kinase. (1324 aa)
LOC103075895Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
SLC8B1Sodium/potassium/calcium exchanger 6, mitochondrial isoform X1; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (600 aa)
LOC103080655chromodomain-helicase-DNA-binding protein 7-like. (414 aa)
TCF7L2Transcription factor 7-like 2. (584 aa)
SLC25A18Mitochondrial glutamate carrier 2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (269 aa)
IL11Interleukin-11 isoform X1. (199 aa)
TFR2Transferrin receptor protein 2. (805 aa)
INHBALOW QUALITY PROTEIN: inhibin beta A chain. (430 aa)
IRS1Insulin receptor substrate 1. (1252 aa)
GHRHRGrowth hormone-releasing hormone receptor isoform X1; Belongs to the G-protein coupled receptor 2 family. (452 aa)
C1QTNF3Complement C1q tumor necrosis factor-related protein 3 isoform X1. (319 aa)
NPVFpro-FMRFamide-related neuropeptide VF. (198 aa)
SCTSecretin. (134 aa)
SLC25A22Mitochondrial glutamate carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (322 aa)
ANO1Anoctamin. (979 aa)
GIPGastric inhibitory polypeptide. (144 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
GCGGlucagon isoform X1. (180 aa)
VSNL1Visinin-like protein 1 isoform X1. (208 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
NR1H4Bile acid receptor isoform X1. (486 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (613 aa)
LOC103090855Deoxyribodipyrimidine photo-lyase-like. (434 aa)
CRY1Cryptochrome-1. (587 aa)
HNF4AHepatocyte nuclear factor 4-alpha isoform X1. (474 aa)
LOC103088397Vesicle-associated membrane protein 7-like isoform X1; Belongs to the synaptobrevin family. (220 aa)
SCG5Neuroendocrine protein 7B2 isoform X1. (212 aa)
SLC9B2Mitochondrial sodium/hydrogen exchanger 9B2. (536 aa)
BADBcl2 antagonist of cell death. (168 aa)
LOC103090072Cyclic AMP-responsive element-binding protein 1-like. (47 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
LOC103071669LOW QUALITY PROTEIN: pro-thyrotropin-releasing hormone-like. (341 aa)
BIRC5Baculoviral IAP repeat-containing protein 5. (142 aa)
C1QTNF1Complement C1q tumor necrosis factor-related protein 1. (279 aa)
OSMoncostatin-M. (246 aa)
LIFLeukemia inhibitory factor. (202 aa)
SYT9Synaptotagmin-9. (589 aa)
CELA2AChymotrypsin-like elastase family member 2A. (179 aa)
PRKCEProtein kinase C; Belongs to the protein kinase superfamily. (493 aa)
KCNJ11ATP-sensitive inward rectifier potassium channel 11 isoform X1. (388 aa)
LOC103070650Ubiquinol-cytochrome-c reductase complex assembly factor 2-like. (136 aa)
MIDNMidnolin. (453 aa)
CDV3Protein CDV3 homolog. (258 aa)
PARK2RBR-type E3 ubiquitin transferase. (274 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (127 aa)
ADCYAP1Pituitary adenylate cyclase-activating polypeptide isoform X1. (176 aa)
HMGN3High mobility group nucleosome-binding domain-containing protein 3 isoform X1. (129 aa)
C2CD2LC2 domain-containing protein 2-like isoform X1. (707 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (245 aa)
LOC103090669RE1-silencing transcription factor-like isoform X1. (986 aa)
KDM5BLysine-specific demethylase 5B. (1352 aa)
LOC103085888Corticotropin-releasing factor receptor 1-like. (129 aa)
CRY2Cryptochrome-2. (593 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
POMCPro-opiomelanocortin. (261 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ANXA1Annexin. (346 aa)
GPLD1Phosphatidylinositol-glycan-specific phospholipase D isoform X1. (839 aa)
RPH3ALRab effector Noc2. (289 aa)
DOC2BDouble C2-like domain-containing protein. (412 aa)
PPP3CBSerine/threonine-protein phosphatase. (480 aa)
ARHGEF7Rho guanine nucleotide exchange factor 7 isoform X2. (803 aa)
SOX4Transcription factor SOX. (306 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (228 aa)
MCUCalcium uniporter protein, mitochondrial. (348 aa)
NDUFAF2Mimitin, mitochondrial. (169 aa)
RFX6DNA-binding protein RFX6. (923 aa)
CHGAchromogranin-A isoform X2. (446 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
PASD1PAS domain-containing protein 1. (354 aa)
C1QTNF6Complement C1q tumor necrosis factor-related protein 6. (266 aa)
PLA2G685/88 kDa calcium-independent phospholipase A2. (805 aa)
GHRLAppetite-regulating hormone isoform X1. (141 aa)
PICK1PRKCA-binding protein isoform X1. (417 aa)
RAB11FIP3Rab11 family-interacting protein 3. (686 aa)
SSTR5Somatostatin receptor type 5; Belongs to the G-protein coupled receptor 1 family. (365 aa)
BAIAP3BAI1-associated protein 3 isoform X1. (1152 aa)
PLA2G3Group 3 secretory phospholipase A2. (516 aa)
CDK16Cyclin-dependent kinase 16 isoform X1; Belongs to the protein kinase superfamily. (496 aa)
PFKLATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (781 aa)
STXBP5LSyntaxin-binding protein 5-like. (1115 aa)
NOS2Nitric oxide synthase; Produces nitric oxide (NO). (1157 aa)
ILDR1Immunoglobulin-like domain-containing receptor 1 isoform X1. (550 aa)
LOC103068503LOW QUALITY PROTEIN: fibrinogen gamma-B chain-like. (445 aa)
CLOCKCircadian locomoter output cycles protein kaput isoform X1. (853 aa)
TFAP2BTranscription factor AP-2-beta isoform X1. (469 aa)
GALR1Galanin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (349 aa)
FGBFibrinogen beta chain isoform X1. (488 aa)
GRPGastrin-releasing peptide isoform X1. (139 aa)
IRS2Insulin receptor substrate 2. (1362 aa)
ADCY5Adenylate cyclase type 5 isoform X1. (1263 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane. Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelial fluid layer. (1482 aa)
RAB11FIP1Rab11 family-interacting protein 1 isoform X1. (1243 aa)
SPP1Osteopontin isoform X1. (296 aa)
PAX8Paired box protein Pax-8. (288 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (493 aa)
NNATNeuronatin isoform X1. (81 aa)
HTR1A5-hydroxytryptamine receptor 1A. (422 aa)
EDN1Endothelin-1. (202 aa)
CRHCorticoliberin. (193 aa)
SNX4Sorting nexin-4. (450 aa)
GPR27Probable G-protein coupled receptor 27. (351 aa)
AACSLOW QUALITY PROTEIN: acetoacetyl-CoA synthetase. (672 aa)
SRISorcin. (198 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
KCNB1Potassium voltage-gated channel subfamily B member 1; Belongs to the potassium channel family. (858 aa)
CCL5C-C motif chemokine. (91 aa)
ALOX5Arachidonate 5-lipoxygenase isoform X1. (674 aa)
SIDT2SID1 transmembrane family member 2. (835 aa)
RASL10BRas-like protein family member 10B. (203 aa)
GCKPhosphotransferase. (466 aa)
CCKARCholecystokinin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
FAM132AProtein FAM132A. (299 aa)
IL6LOW QUALITY PROTEIN: interleukin-6. (243 aa)
TMF1TATA element modulatory factor. (1093 aa)
GHRHSomatoliberin isoform X1. (106 aa)
ICA1Islet cell autoantigen 1 isoform X1. (517 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (829 aa)
ADCY8Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1250 aa)
STXBP4Syntaxin-binding protein 4. (558 aa)
SIRT4NAD-dependent protein lipoamidase sirtuin-4, mitochondrial; Acts as NAD-dependent protein lipoamidase, ADP-ribosyl transferase and deacetylase. Catalyzes more efficiently removal of lipoyl- and biotinyl- than acetyl-lysine modifications. Inhibits the pyruvate dehydrogenase complex (PDH) activity via the enzymatic hydrolysis of the lipoamide cofactor from the E2 component, DLAT, in a phosphorylation-independent manner. Catalyzes the transfer of ADP- ribosyl groups onto target proteins, including mitochondrial GLUD1, inhibiting GLUD1 enzyme activity. Acts as a negative regulator of mitoc [...] (314 aa)
HNF1AHepatocyte nuclear factor 1-alpha. (632 aa)
GPR68Ovarian cancer G-protein coupled receptor 1; Belongs to the G-protein coupled receptor 1 family. (371 aa)
PDX1Pancreas/duodenum homeobox protein 1. (286 aa)
LRRC8ALeucine-rich repeat-containing protein 8A. (810 aa)
GJA1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (383 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (822 aa)
FOXO1Forkhead box protein O1. (655 aa)
BLKTyrosine-protein kinase. (501 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2305 aa)
FFAR4Free fatty acid receptor 4 isoform X1. (360 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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