44 items (Lipotes vexillifer) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3058 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	AIRE	Autoimmune regulator. (562 aa)
	MAPK3	Mitogen-activated protein kinase. (325 aa)
	PAX1	Paired box protein Pax-1. (450 aa)
	HAND2	Heart- and neural crest derivatives-expressed protein 2. (165 aa)
	SHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
	CTC1	CST complex subunit CTC1. (1210 aa)
	BCL11B	B-cell lymphoma/leukemia 11B isoform X1. (902 aa)
	RIPK3	LOW QUALITY PROTEIN: receptor-interacting serine-threonine kinase 3. (396 aa)
	LOC103082395	Homeobox protein SIX4-like. (300 aa)
	SIX1	Homeobox protein SIX1. (284 aa)
	BCL2L11	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (196 aa)
	SIX4	Homeobox protein SIX4-like. (786 aa)
	EPHB3	Ephrin type-B receptor 3. (1005 aa)
	MAD1L1	Mitotic spindle assembly checkpoint protein MAD1. (582 aa)
	BRAF	Serine/threonine-protein kinase B-raf. (763 aa)
	HOXA3	Homeobox protein Hox-A3. (385 aa)
	GATA3	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1. (444 aa)
	CITED2	Cbp/p300-interacting transactivator 2 isoform X1. (272 aa)
	LOC103072712	Mitotic spindle assembly checkpoint protein MAD1-like. (330 aa)
	MAFB	Transcription factor MafB. (277 aa)
	CTNNB1	Catenin beta-1 isoform X1. (781 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (211 aa)
	BCL2	Apoptosis regulator Bcl-2. (232 aa)
	CACNB4	Voltage-dependent L-type calcium channel subunit beta-4 isoform X1. (519 aa)
	RAF1	RAF proto-oncogene serine/threonine-protein kinase isoform X1. (648 aa)
	JARID2	LOW QUALITY PROTEIN: protein Jumonji. (1237 aa)
	ZBTB1	Zinc finger and BTB domain-containing protein 1. (713 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
	FOXE1	Forkhead box protein E1. (373 aa)
	PSEN1	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
	ABL1	Tyrosine-protein kinase. (1006 aa)
	SRF	Serum response factor. (510 aa)
	HES1	Transcription factor HES-1. (280 aa)
	LOC103079308	Uncharacterized protein LOC103079308. (289 aa)
	FOXN1	Forkhead box protein N1. (645 aa)
	CRKL	Crk-like protein. (303 aa)
	SLC46A2	Thymic stromal cotransporter homolog. (475 aa)
	MAPK1	Mitogen-activated protein kinase 1 isoform X1. (263 aa)
	MAP2K1	Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
	ASXL1	Putative Polycomb group protein ASXL1. (1544 aa)
	LOC103070587	Tyrosine-protein kinase ABL1-like. (126 aa)

Your Current Organism:

Lipotes vexillifer

NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	ATM	A0A340WVZ5	A0A340WCK4	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.839
ABL1	CRKL	A0A340WVZ5	A0A340WQH1	Tyrosine-protein kinase.	Crk-like protein.	0.956
ABL1	CTNNB1	A0A340WVZ5	A0A340XZA8	Tyrosine-protein kinase.	Catenin beta-1 isoform X1.	0.480
ABL1	EPHB3	A0A340WVZ5	A0A340YC64	Tyrosine-protein kinase.	Ephrin type-B receptor 3.	0.926
AIRE	FOXN1	A0A340WY41	A0A340WU40	Autoimmune regulator.	Forkhead box protein N1.	0.775
ATM	ABL1	A0A340WCK4	A0A340WVZ5	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.839
ATM	BCL2	A0A340WCK4	A0A340XUD3	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Apoptosis regulator Bcl-2.	0.535
ATM	BRAF	A0A340WCK4	A0A340Y5C2	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase B-raf.	0.553
ATM	CTNNB1	A0A340WCK4	A0A340XZA8	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Catenin beta-1 isoform X1.	0.474
ATM	LOC103070587	A0A340WCK4	A0A340WDD9	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase ABL1-like.	0.839
BCL11B	GATA3	A0A340X9L8	A0A340Y2J9	B-cell lymphoma/leukemia 11B isoform X1.	Trans-acting T-cell-specific transcription factor GATA-3 isoform X1.	0.486
BCL2	ATM	A0A340XUD3	A0A340WCK4	Apoptosis regulator Bcl-2.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.535
BCL2	BCL2L11	A0A340XUD3	A0A340YE57	Apoptosis regulator Bcl-2.	Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family.	0.995
BCL2	BRAF	A0A340XUD3	A0A340Y5C2	Apoptosis regulator Bcl-2.	Serine/threonine-protein kinase B-raf.	0.572
BCL2	CTNNB1	A0A340XUD3	A0A340XZA8	Apoptosis regulator Bcl-2.	Catenin beta-1 isoform X1.	0.654
BCL2	FADD	A0A340XUD3	A0A340XXK1	Apoptosis regulator Bcl-2.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.622
BCL2	MAPK1	A0A340XUD3	A0A340WNH5	Apoptosis regulator Bcl-2.	Mitogen-activated protein kinase 1 isoform X1.	0.945
BCL2	MAPK3	A0A340XUD3	A0A340WYU9	Apoptosis regulator Bcl-2.	Mitogen-activated protein kinase.	0.945
BCL2	PSEN1	A0A340XUD3	A0A340XI58	Apoptosis regulator Bcl-2.	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.	0.506
BCL2	RAF1	A0A340XUD3	A0A340XQI5	Apoptosis regulator Bcl-2.	RAF proto-oncogene serine/threonine-protein kinase isoform X1.	0.521