STRINGSTRING
VWA5B2 VWA5B2 TNNI1 TNNI1 PPP1R13L PPP1R13L WNT5A WNT5A SRF SRF BMPR1A BMPR1A FHL2 FHL2 MYBPC3 MYBPC3 LMNA LMNA GJC1 GJC1 PRKAR1A PRKAR1A DSG2 DSG2 PTCD2 PTCD2 WNT3A WNT3A TNNT2 TNNT2 PDGFRA PDGFRA CBY1 CBY1 TENM4 TENM4 TSC1 TSC1 HAND1 HAND1 FHOD3 FHOD3 MYOCD MYOCD PLN PLN ACTN2 ACTN2 PKP2 PKP2 MAPK11 MAPK11 ZMPSTE24 ZMPSTE24 SIK1 SIK1 NPRL3 NPRL3 RYR2 RYR2 WNT2 WNT2 SGCD SGCD MYLK3 MYLK3 ZIC3 ZIC3 LRP2 LRP2 ALPK2 ALPK2 TNNC1 TNNC1 S1PR1 S1PR1 SGCZ SGCZ PROX1 PROX1 LOC103085851 LOC103085851 GATA6 GATA6 LOC103072909 LOC103072909 ACADM ACADM LOC103083261 LOC103083261 BMP7 BMP7 LOC103080337 LOC103080337 SAV1 SAV1 ADPRH ADPRH ZFPM2 ZFPM2 HEY2 HEY2 TBX20 TBX20 MYL7 MYL7 ALPK3 ALPK3 ASB2 ASB2 MYLK2 MYLK2 BMP4 BMP4 MEF2A MEF2A TGFB1 TGFB1 ALDH1A2 ALDH1A2 NKX2-6 NKX2-6 SLC9A1 SLC9A1 NOTCH1 NOTCH1 VWA5B1 VWA5B1 TGFBR1 TGFBR1 GATA5 GATA5 DLL4 DLL4 MYO18B MYO18B GREM1 GREM1 JARID2 JARID2 LOC103073422 LOC103073422 LRRC10B LRRC10B PRMT1 PRMT1 HNRNPU HNRNPU NOX4 NOX4 ARID2 ARID2 BMP10 BMP10 MTOR MTOR PLEC PLEC LRRC10 LRRC10 TBX2 TBX2 NOG NOG LOC103079709 LOC103079709 MED1 MED1 LOC103084351 LOC103084351 LOC103073985 LOC103073985 RARB RARB FGF9 FGF9 SMAD4 SMAD4 CAV3 CAV3 BVES BVES ATG5 ATG5 TCAP TCAP RARA RARA NEB NEB ADPRHL1 ADPRHL1 XIRP2 XIRP2 FOXH1 FOXH1 DSP DSP NKX2-5 NKX2-5 SMAD7 SMAD7 POU4F1 POU4F1 EGLN1 EGLN1 MEF2C MEF2C MAML1 MAML1 MYL2 MYL2 ADRA1A ADRA1A MYL10 MYL10 SMAD1 SMAD1 TBX18 TBX18 LOC103080655 LOC103080655 ZFPM1 ZFPM1 TBX5 TBX5 BMP2 BMP2 MESP1 MESP1 NRAP NRAP ISL1 ISL1 EDNRA EDNRA IFT20 IFT20 MYL3 MYL3 TGFB2 TGFB2 CHD7 CHD7 SGCG SGCG LOC103072657 LOC103072657 TREX1 TREX1 ENG ENG ITGB1 ITGB1 NDUFV2 NDUFV2 LOC103088826 LOC103088826 NEBL NEBL IRX3 IRX3 CSRP3 CSRP3 LOC103068714 LOC103068714
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VWA5B2Von Willebrand factor A domain-containing protein 5B2. (1255 aa)
TNNI1LOW QUALITY PROTEIN: troponin I, slow skeletal muscle. (224 aa)
PPP1R13LrelA-associated inhibitor isoform X1. (828 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SRFSerum response factor. (510 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
FHL2Four and a half LIM domains protein 2 isoform X1. (307 aa)
MYBPC3Myosin-binding protein C, cardiac-type. (1272 aa)
LMNAprelamin-A/C isoform X1; Belongs to the intermediate filament family. (664 aa)
GJC1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (380 aa)
DSG2Desmoglein-2. (1191 aa)
PTCD2Pentatricopeptide repeat-containing protein 2, mitochondrial isoform X1. (387 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
TNNT2Troponin T, cardiac muscle. (280 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
CBY1Protein chibby homolog 1. (127 aa)
TENM4Teneurin-4-like. (2768 aa)
TSC1Hamartin isoform X1. (1170 aa)
HAND1Heart- and neural crest derivatives-expressed protein 1. (218 aa)
FHOD3LOW QUALITY PROTEIN: FH1/FH2 domain-containing protein 3. (1436 aa)
MYOCDMyocardin isoform X1. (984 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
ACTN2Alpha-actinin-2 isoform X1. (907 aa)
PKP2Plakophilin-2. (826 aa)
MAPK11Mitogen-activated protein kinase. (350 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
SIK1Serine/threonine-protein kinase SIK1. (784 aa)
NPRL3Nitrogen permease regulator 3-like protein isoform X2. (582 aa)
RYR2Ryanodine receptor 2-like. (4986 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SGCDDelta-sarcoglycan-like. (289 aa)
MYLK3Myosin light chain kinase 3. (800 aa)
ZIC3LOW QUALITY PROTEIN: zinc finger protein ZIC 3. (468 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4672 aa)
ALPK2LOW QUALITY PROTEIN: alpha-protein kinase 2. (2171 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles. (161 aa)
S1PR1Sphingosine 1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (382 aa)
SGCZZeta-sarcoglycan. (312 aa)
PROX1Prospero homeobox protein 1. (737 aa)
LOC103085851Transcription factor GATA-6-like. (426 aa)
GATA6Transcription factor GATA-6-like. (592 aa)
LOC103072909Protein HEG homolog 1-like. (136 aa)
ACADMMedium-chain specific acyl-CoA dehydrogenase, mitochondrial. (421 aa)
LOC103083261Protein HEG homolog 1-like. (1196 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
LOC103080337Deleted in autism protein 1. (430 aa)
SAV1Protein salvador homolog 1. (384 aa)
ADPRH[Protein ADP-ribosylarginine] hydrolase. (362 aa)
ZFPM2Zinc finger protein ZFPM2 isoform X1. (1151 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (352 aa)
TBX20T-box transcription factor TBX20. (449 aa)
MYL7Myosin regulatory light chain 2, atrial isoform. (148 aa)
ALPK3LOW QUALITY PROTEIN: alpha-protein kinase 3. (1858 aa)
ASB2Ankyrin repeat and SOCS box protein 2. (633 aa)
MYLK2Myosin light chain kinase 2, skeletal/cardiac muscle. (597 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X1. (503 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (518 aa)
NKX2-6Homeobox protein Nkx-2.6. (300 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
VWA5B1LOW QUALITY PROTEIN: von Willebrand factor A domain-containing protein 5B1. (1226 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
GATA5Transcription factor GATA-5. (407 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
MYO18BUnconventional myosin-XVIIIb; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2526 aa)
GREM1Gremlin. (184 aa)
JARID2LOW QUALITY PROTEIN: protein Jumonji. (1237 aa)
LOC103073422LOW QUALITY PROTEIN: short stature homeobox protein 2-like. (359 aa)
LRRC10BLeucine-rich repeat-containing protein 10B. (292 aa)
PRMT1Protein arginine N-methyltransferase 1 isoform X1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (371 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U isoform X1. (824 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
ARID2AT-rich interactive domain-containing protein 2. (1835 aa)
BMP10Bone morphogenetic protein 10. (421 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
PLECPlectin. (4678 aa)
LRRC10Leucine-rich repeat-containing protein 10. (285 aa)
TBX2T-box transcription factor TBX2. (875 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LOC103079709NADP-dependent glyceraldehyde-3-phosphate dehydrogenase-like. (539 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
LOC103084351LOW QUALITY PROTEIN: T-box transcription factor TBX3-like. (737 aa)
LOC103073985Ankyrin repeat domain-containing protein 1-like. (319 aa)
RARBRetinoic acid receptor beta isoform X1. (458 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
BVESBlood vessel epicardial substance isoform X1. (428 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
TCAPTelethonin. (167 aa)
RARARetinoic acid receptor alpha isoform X1. (462 aa)
NEBNebulin-like. (2432 aa)
ADPRHL1[Protein ADP-ribosylarginine] hydrolase-like protein 1. (354 aa)
XIRP2Xin actin-binding repeat-containing protein 2-like isoform X1. (3545 aa)
FOXH1Forkhead box protein H1. (360 aa)
DSPDesmoplakin isoform X1. (2877 aa)
NKX2-5Homeobox protein Nkx-2.5. (324 aa)
SMAD7Mothers against decapentaplegic homolog. (427 aa)
POU4F1POU domain protein. (388 aa)
EGLN1Egl nine homolog 1. (400 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
MAML1LOW QUALITY PROTEIN: mastermind-like protein 1. (1018 aa)
MYL2Myosin regulatory light chain 2, ventricular/cardiac muscle isoform. (166 aa)
ADRA1Aalpha-1A adrenergic receptor. (467 aa)
MYL10Myosin regulatory light chain 10. (147 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TBX18T-box transcription factor TBX18. (612 aa)
LOC103080655chromodomain-helicase-DNA-binding protein 7-like. (414 aa)
ZFPM1Zinc finger protein ZFPM1. (988 aa)
TBX5T-box transcription factor TBX5 isoform X1. (519 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
MESP1Mesoderm posterior protein 1. (267 aa)
NRAPLOW QUALITY PROTEIN: nebulin-related-anchoring protein. (1737 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
EDNRAEndothelin-1 receptor isoform X2. (318 aa)
IFT20LOW QUALITY PROTEIN: intraflagellar transport 20 homolog (Chlamydomonas). (159 aa)
MYL3Myosin light chain 3. (197 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CHD7chromodomain-helicase-DNA-binding protein 7. (2305 aa)
SGCGGamma-sarcoglycan. (291 aa)
LOC103072657Coxsackievirus and adenovirus receptor homolog. (440 aa)
TREX1LOW QUALITY PROTEIN: three prime repair exonuclease 1. (368 aa)
ENGEndoglin. (661 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
NDUFV2NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial. (249 aa)
LOC103088826Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (143 aa)
NEBLLIM zinc-binding domain-containing Nebulette isoform X1. (1013 aa)
IRX3Iroquois-class homeodomain protein IRX-3. (503 aa)
CSRP3Cysteine and glycine-rich protein 3. (194 aa)
LOC103068714Uncharacterized protein. (168 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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