STRINGSTRING
IHH IHH SRC SRC AR AR KRAS KRAS PAX8 PAX8 BMP4 BMP4 KDR KDR DLG5 DLG5 PPP3R1 PPP3R1 GPC3 GPC3 HHIP HHIP GBX2 GBX2 ENG ENG SIX1 SIX1 BTRC BTRC EDNRA EDNRA FGF8 FGF8 PAX2 PAX2 SPRY1 SPRY1 BMP2 BMP2 FGF2 FGF2 LOC103077051 LOC103077051 PHB2 PHB2 FOXF1 FOXF1 GLI3 GLI3 TIMELESS TIMELESS FGF1 FGF1 TIE1 TIE1 HOXA11 HOXA11 HOXA5 HOXA5 DLG1 DLG1 CITED1 CITED1 WNT9B WNT9B SFRP2 SFRP2 FOXA1 FOXA1 STK4 STK4 SPRY2 SPRY2 SLIT2 SLIT2 CTNNB1 CTNNB1 VDR VDR SMAD4 SMAD4 LOC103084351 LOC103084351 MED1 MED1 EGF EGF TBX2 TBX2 LHX1 LHX1 BCL2 BCL2 HS3ST3A1 HS3ST3A1 LOC103077930 LOC103077930 LAMA5 LAMA5 WNT1 WNT1 RDH10 RDH10 ADAMTS16 ADAMTS16 EXT1 EXT1 SOX9 SOX9 LEF1 LEF1 TCF21 TCF21 CTNNBIP1 CTNNBIP1 COL4A1 COL4A1 GDF2 GDF2 PKD1 PKD1 CSMD2 CSMD2 CELSR1 CELSR1 PPP3R2 PPP3R2 GNA13 GNA13 GDNF GDNF DLG2 DLG2 SHH SHH GZF1 GZF1 EDN1 EDN1 SEMA3E SEMA3E CCL11 CCL11 SRF SRF WNT5A WNT5A KDM5B KDM5B NKX3-1 NKX3-1 ESR1 ESR1 GREB1 GREB1 CLIC4 CLIC4 LOC103079308 LOC103079308 CTSH CTSH NRARP NRARP EYA1 EYA1 WT1 WT1 TGFB1 TGFB1 ILK ILK LOC103080038 LOC103080038 NOTCH1 NOTCH1 EPHA2 EPHA2 FGF10 FGF10 DCHS1 DCHS1 DLL4 DLL4 PLXND1 PLXND1 PAK1 PAK1 ESRP2 ESRP2 AREG AREG RASIP1 RASIP1 TMEM59L TMEM59L GDF7 GDF7 HS3ST3B1 HS3ST3B1 TBX20 TBX20 MKS1 MKS1 PML PML BMP7 BMP7 YAP1 YAP1 GREB1L GREB1L LOC103087231 LOC103087231 CSF1 CSF1 MMP14 MMP14 LRP5 LRP5 PTCH1 PTCH1 MET MET CTSZ CTSZ DDR1 DDR1 RBM15 RBM15 PKHD1 PKHD1 PPP1CA PPP1CA PKD2 PKD2 NFATC4 NFATC4 WNT6 WNT6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
SRCTyrosine-protein kinase. (548 aa)
ARAndrogen receptor. (888 aa)
KRASGTPase KRas. (188 aa)
PAX8Paired box protein Pax-8. (288 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
KDRVascular endothelial growth factor receptor 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1356 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1921 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
GPC3Glypican-3 isoform X1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (580 aa)
HHIPHedgehog-interacting protein-like isoform X1. (700 aa)
GBX2Homeobox protein GBX-2. (348 aa)
ENGEndoglin. (661 aa)
SIX1Homeobox protein SIX1. (284 aa)
BTRCF-box/WD repeat-containing protein 1A. (579 aa)
EDNRAEndothelin-1 receptor isoform X2. (318 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
PAX2Paired box protein Pax-2 isoform X5. (432 aa)
SPRY1Protein sprouty homolog 1 isoform X1. (319 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
LOC103077051CUB and sushi domain-containing protein 1-like. (431 aa)
PHB2Prohibitin. (299 aa)
FOXF1Forkhead box protein F1. (377 aa)
GLI3Transcriptional activator GLI3. (1590 aa)
TIMELESSProtein timeless homolog. (1202 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
TIE1Tyrosine-protein kinase receptor Tie-1 isoform X1. (1139 aa)
HOXA11Homeobox protein Hox-A11. (317 aa)
HOXA5Homeobox protein Hox-A5. (270 aa)
DLG1Disks large homolog 1 isoform X1; Belongs to the MAGUK family. (927 aa)
CITED1Cbp/p300-interacting transactivator 1 isoform X1. (221 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
SFRP2Secreted frizzled-related protein 2. (294 aa)
FOXA1Hepatocyte nuclear factor 3-alpha. (466 aa)
STK4Serine/threonine-protein kinase 4. (487 aa)
SPRY2Protein sprouty homolog 2 isoform X1. (315 aa)
SLIT2LOW QUALITY PROTEIN: slit homolog 2 protein. (1521 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
VDRVitamin D3 receptor isoform X1. (427 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
LOC103084351LOW QUALITY PROTEIN: T-box transcription factor TBX3-like. (737 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1579 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
TBX2T-box transcription factor TBX2. (875 aa)
LHX1LIM/homeobox protein Lhx1. (406 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
HS3ST3A1Sulfotransferase; Belongs to the sulfotransferase 1 family. (406 aa)
LOC103077930Thyroid transcription factor 1-like isoform X2. (402 aa)
LAMA5Laminin subunit alpha-5. (3689 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ADAMTS16A disintegrin and metalloproteinase with thrombospondin motifs 16. (1240 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (750 aa)
SOX9Transcription factor SOX-9 isoform X1. (509 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
TCF21LOW QUALITY PROTEIN: transcription factor 21. (179 aa)
CTNNBIP1Beta-catenin-interacting protein 1 isoform X1. (81 aa)
COL4A1Collagen alpha-1(IV) chain. (1668 aa)
GDF2Growth/differentiation factor 2. (431 aa)
PKD1Polycystin-1. (4305 aa)
CSMD2CUB and sushi domain-containing protein 2. (3546 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (3319 aa)
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
GNA13Guanine nucleotide-binding protein subunit alpha-13 isoform X1. (377 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
DLG2Disks large homolog 2-like isoform X1. (905 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
GZF1LOW QUALITY PROTEIN: GDNF-inducible zinc finger protein 1. (720 aa)
EDN1Endothelin-1. (202 aa)
SEMA3Esemaphorin-3E-like; Belongs to the semaphorin family. (715 aa)
CCL11C-C motif chemokine. (99 aa)
SRFSerum response factor. (510 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KDM5BLysine-specific demethylase 5B. (1352 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (245 aa)
ESR1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (595 aa)
GREB1Protein GREB1. (1944 aa)
CLIC4Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (253 aa)
LOC103079308Uncharacterized protein LOC103079308. (289 aa)
CTSHPro-cathepsin H isoform X1; Belongs to the peptidase C1 family. (335 aa)
NRARPNotch-regulated ankyrin repeat-containing protein. (114 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (594 aa)
WT1Wilms tumor protein isoform X1. (450 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ILKIntegrin-linked protein kinase isoform X1. (452 aa)
LOC103080038Sulfotransferase; Belongs to the sulfotransferase 1 family. (201 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
EPHA2Ephrin type-A receptor 2. (975 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
DCHS1Protocadherin-16. (3294 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
PLXND1plexin-D1. (1747 aa)
PAK1Non-specific serine/threonine protein kinase. (563 aa)
ESRP2Epithelial splicing regulatory protein 2. (717 aa)
AREGAmphiregulin isoform X1. (254 aa)
RASIP1Ras-interacting protein 1. (962 aa)
TMEM59LTransmembrane protein 59-like isoform X1. (351 aa)
GDF7Growth/differentiation factor 7. (457 aa)
HS3ST3B1Sulfotransferase; Belongs to the sulfotransferase 1 family. (390 aa)
TBX20T-box transcription factor TBX20. (449 aa)
MKS1LOW QUALITY PROTEIN: Meckel syndrome type 1 protein. (562 aa)
PMLProtein PML. (848 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
YAP1Yorkie homolog. (430 aa)
GREB1LGREB1-like protein. (1856 aa)
LOC103087231Yorkie homolog isoform X1. (489 aa)
CSF1Macrophage colony-stimulating factor 1; Cytokine that plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. Required for normal male and female [...] (553 aa)
MMP14Matrix metalloproteinase-14 isoform X2. (582 aa)
LRP5Low-density lipoprotein receptor-related protein 5. (1451 aa)
PTCH1Protein patched homolog 1 isoform X1. (1448 aa)
METHepatocyte growth factor receptor isoform X1. (1412 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (303 aa)
DDR1Tyrosine-protein kinase receptor. (923 aa)
RBM15Putative RNA-binding protein 15 isoform X1. (1005 aa)
PKHD1Fibrocystin. (4074 aa)
PPP1CASerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (330 aa)
PKD2LOW QUALITY PROTEIN: polycystin-2. (963 aa)
NFATC4Nuclear factor of activated T-cells, cytoplasmic 4 isoform X1. (901 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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