STRINGSTRING
PPP3R2 PPP3R2 KLHL12 KLHL12 HEYL HEYL FRZB FRZB CDH2 CDH2 SOX8 SOX8 TCF21 TCF21 LEF1 LEF1 MAPK3 MAPK3 SOX9 SOX9 SEMA3G SEMA3G SOX10 SOX10 FAM208A FAM208A EXT1 EXT1 RDH10 RDH10 WNT2 WNT2 AKNA AKNA JAG1 JAG1 SEMA6A SEMA6A RET RET LOC103082455 LOC103082455 MAPK1 MAPK1 OTUD5 OTUD5 GSK3B GSK3B ANXA6 ANXA6 AMER1 AMER1 TCOF1 TCOF1 LOC103085466 LOC103085466 FAM83D FAM83D SEMA5B SEMA5B BMP7 BMP7 SIX2 SIX2 CORO1C CORO1C ACVR1 ACVR1 HEY2 HEY2 LOC103083351 LOC103083351 TBX20 TBX20 EDN1 EDN1 SNAI1 SNAI1 KBTBD8 KBTBD8 SEMA4D SEMA4D HMGA2 HMGA2 GSC GSC RADIL RADIL WNT10A WNT10A SEMA7A SEMA7A BMP4 BMP4 HAS2 HAS2 ENG ENG LOC103088826 LOC103088826 SEMA6C SEMA6C ADAM15 ADAM15 NRTN NRTN WNT16 WNT16 SEMA6B SEMA6B SEMA4F SEMA4F TGFB1 TGFB1 ALDH1A2 ALDH1A2 NOTCH1 NOTCH1 NOTCH4 NOTCH4 TGFBR1 TGFBR1 WNT11 WNT11 FGF10 FGF10 HTR2B HTR2B TMEM100 TMEM100 LOC103081344 LOC103081344 PHACTR4 PHACTR4 TGFBR3L TGFBR3L SEMA5A SEMA5A SEMA3D SEMA3D GBX2 GBX2 SNAI2 SNAI2 PPP3R1 PPP3R1 RANBP3L RANBP3L LOXL2 LOXL2 WNT5A WNT5A BMPR1A BMPR1A CUL7 CUL7 SFRP1 SFRP1 SEMA3E SEMA3E LOC103086357 LOC103086357 TRIM28 TRIM28 SHH SHH GDNF GDNF TWIST1 TWIST1 FAM101B FAM101B HAND2 HAND2 DDX17 DDX17 SEMA4C SEMA4C SEMA4G SEMA4G TGFB2 TGFB2 SIX1 SIX1 HIF1A HIF1A LOC103076534 LOC103076534 DLG5 DLG5 LAMA5 LAMA5 BCL2 BCL2 SEMA3A SEMA3A NOG NOG LOC103079709 LOC103079709 LOC103084351 LOC103084351 SMAD4 SMAD4 OSR1 OSR1 MSX1 MSX1 SEMA3C SEMA3C MEF2C MEF2C SEMA3B SEMA3B CITED2 CITED2 RTN4 RTN4 EDNRB EDNRB SEMA3F SEMA3F EPB41L5 EPB41L5 FAM172A FAM172A ERBB4 ERBB4 TGFBR3 TGFBR3 PEF1 PEF1 BMP2 BMP2 FGFR1 FGFR1 LRP6 LRP6 NRP2 NRP2 FGF8 FGF8 NOLC1 NOLC1 PDCD6 PDCD6 SMO SMO ISL1 ISL1 EDNRA EDNRA WWTR1 WWTR1 NRP1 NRP1 SEMA4B SEMA4B LOC103075821 LOC103075821 EFNB1 EFNB1 FLNA FLNA LOC103079308 LOC103079308 EFNA1 EFNA1 SEMA4A SEMA4A DDX5 DDX5 ALX1 ALX1 HES1 HES1 FN1 FN1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP3R2LOW QUALITY PROTEIN: calcineurin subunit B type 2. (170 aa)
KLHL12Kelch-like protein 12. (606 aa)
HEYLHairy/enhancer-of-split related with YRPW motif-like protein isoform X1. (323 aa)
FRZBSecreted frizzled-related protein 3. (325 aa)
CDH2Cadherin-2 isoform X1; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
SOX8Transcription factor SOX-8. (463 aa)
TCF21LOW QUALITY PROTEIN: transcription factor 21. (179 aa)
LEF1Lymphoid enhancer-binding factor 1 isoform X1. (399 aa)
MAPK3Mitogen-activated protein kinase. (325 aa)
SOX9Transcription factor SOX-9 isoform X1. (509 aa)
SEMA3Gsemaphorin-3G; Belongs to the semaphorin family. (772 aa)
SOX10Transcription factor SOX-10 isoform X1. (468 aa)
FAM208AProtein FAM208A isoform X1. (1667 aa)
EXT1Exostosin-1; Belongs to the glycosyltransferase 47 family. (750 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
AKNAAT-hook-containing transcription factor. (1427 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SEMA6Asemaphorin-6A isoform X1; Belongs to the semaphorin family. (1044 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1026 aa)
LOC103082455Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
MAPK1Mitogen-activated protein kinase 1 isoform X1. (263 aa)
OTUD5OTU domain-containing protein 5 isoform X2. (570 aa)
GSK3BGlycogen synthase kinase-3 beta isoform X1; Belongs to the protein kinase superfamily. (433 aa)
ANXA6Annexin. (672 aa)
AMER1APC membrane recruitment protein 1. (1119 aa)
TCOF1Treacle protein isoform X1. (1418 aa)
LOC103085466Band 4.1-like protein 5-like. (256 aa)
FAM83DProtein FAM83D. (560 aa)
SEMA5Bsemaphorin-5B isoform X1. (1093 aa)
BMP7Bone morphogenetic protein 7 isoform X1. (431 aa)
SIX2Homeobox protein SIX2. (296 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HEY2Hairy/enhancer-of-split related with YRPW motif protein 2. (352 aa)
LOC103083351LOW QUALITY PROTEIN: semaphorin-6D-like; Belongs to the semaphorin family. (1131 aa)
TBX20T-box transcription factor TBX20. (449 aa)
EDN1Endothelin-1. (202 aa)
SNAI1Zinc finger protein SNAI1. (264 aa)
KBTBD8Kelch repeat and BTB domain-containing protein 8. (601 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
GSCHomeobox protein goosecoid. (256 aa)
RADILLOW QUALITY PROTEIN: ras-associating and dilute domain-containing protein. (1081 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SEMA7Asemaphorin-7A isoform X1; Belongs to the semaphorin family. (663 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
HAS2Hyaluronan synthase 2-like. (552 aa)
ENGEndoglin. (661 aa)
LOC103088826Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (143 aa)
SEMA6Csemaphorin-6C isoform X1; Belongs to the semaphorin family. (966 aa)
ADAM15Disintegrin and metalloproteinase domain-containing protein 15 isoform X1. (866 aa)
NRTNNeurturin. (197 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (363 aa)
SEMA6Bsemaphorin-6B; Belongs to the semaphorin family. (812 aa)
SEMA4Fsemaphorin-4F; Belongs to the semaphorin family. (777 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
ALDH1A2Retinal dehydrogenase 2 isoform X1; Belongs to the aldehyde dehydrogenase family. (518 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
NOTCH4Neurogenic locus notch homolog protein 4. (1993 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (499 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
TMEM100Transmembrane protein 100. (134 aa)
LOC103081344Folate receptor alpha-like. (251 aa)
PHACTR4Phosphatase and actin regulator. (816 aa)
TGFBR3LTransforming growth factor-beta receptor type 3-like protein. (389 aa)
SEMA5Asemaphorin-5A. (1073 aa)
SEMA3Dsemaphorin-3D; Belongs to the semaphorin family. (777 aa)
GBX2Homeobox protein GBX-2. (348 aa)
SNAI2Zinc finger protein SNAI2. (268 aa)
PPP3R1Calcineurin subunit B type 1. (160 aa)
RANBP3LRan-binding protein 3-like isoform X1. (493 aa)
LOXL2Lysyl oxidase homolog 2 isoform X1. (774 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
CUL7Cullin-7 isoform X1; Belongs to the cullin family. (1726 aa)
SFRP1Secreted frizzled-related protein 1. (308 aa)
SEMA3Esemaphorin-3E-like; Belongs to the semaphorin family. (715 aa)
LOC103086357Protein scribble homolog. (347 aa)
TRIM28Transcription intermediary factor 1-beta. (830 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
GDNFGlial cell line-derived neurotrophic factor isoform X1. (211 aa)
TWIST1Twist-related protein 1 isoform X1. (204 aa)
FAM101BProtein FAM101B. (218 aa)
HAND2Heart- and neural crest derivatives-expressed protein 2. (165 aa)
DDX17Probable ATP-dependent RNA helicase DDX17 isoform X1; Belongs to the DEAD box helicase family. (652 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
SEMA4Gsemaphorin-4G; Belongs to the semaphorin family. (843 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
SIX1Homeobox protein SIX1. (284 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (822 aa)
LOC103076534Cytochrome P450 26C1-like; Belongs to the cytochrome P450 family. (523 aa)
DLG5Disks large homolog 5; Belongs to the MAGUK family. (1921 aa)
LAMA5Laminin subunit alpha-5. (3689 aa)
BCL2Apoptosis regulator Bcl-2. (232 aa)
SEMA3Asemaphorin-3A; Belongs to the semaphorin family. (772 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LOC103079709NADP-dependent glyceraldehyde-3-phosphate dehydrogenase-like. (539 aa)
LOC103084351LOW QUALITY PROTEIN: T-box transcription factor TBX3-like. (737 aa)
SMAD4Mothers against decapentaplegic homolog. (553 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
MSX1Homeobox protein MSX-1. (303 aa)
SEMA3Csemaphorin-3C; Belongs to the semaphorin family. (751 aa)
MEF2CMyocyte-specific enhancer factor 2C isoform X1. (483 aa)
SEMA3Bsemaphorin-3B isoform X3; Belongs to the semaphorin family. (753 aa)
CITED2Cbp/p300-interacting transactivator 2 isoform X1. (272 aa)
RTN4Reticulon. (1187 aa)
EDNRBEndothelin B receptor; Belongs to the G-protein coupled receptor 1 family. (443 aa)
SEMA3Fsemaphorin-3F isoform X1; Belongs to the semaphorin family. (785 aa)
EPB41L5LOW QUALITY PROTEIN: band 4.1-like protein 5. (505 aa)
FAM172AProtein FAM172A isoform X1. (416 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
TGFBR3Transforming growth factor beta receptor type 3. (851 aa)
PEF1Peflin. (289 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
LRP6Low-density lipoprotein receptor-related protein 6 isoform X1. (1463 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (931 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1 isoform X1. (712 aa)
PDCD6Programmed cell death protein 6 isoform X1. (189 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
EDNRAEndothelin-1 receptor isoform X2. (318 aa)
WWTR1WW domain-containing transcription regulator protein 1. (400 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
SEMA4Bsemaphorin-4B; Belongs to the semaphorin family. (822 aa)
LOC103075821DEAD-box ATP-dependent RNA helicase 9-like; Belongs to the DEAD box helicase family. (319 aa)
EFNB1ephrin-B1; Belongs to the ephrin family. (346 aa)
FLNAfilamin-A isoform X1. (2647 aa)
LOC103079308Uncharacterized protein LOC103079308. (289 aa)
EFNA1ephrin-A1; Belongs to the ephrin family. (242 aa)
SEMA4Asemaphorin-4A; Belongs to the semaphorin family. (762 aa)
DDX5Probable ATP-dependent RNA helicase DDX5 isoform X1; Belongs to the DEAD box helicase family. (614 aa)
ALX1ALX homeobox protein 1. (326 aa)
HES1Transcription factor HES-1. (280 aa)
FN1LOW QUALITY PROTEIN: fibronectin. (2483 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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