STRINGSTRING
HBEGF HBEGF LOC103069874 LOC103069874 PTPRC PTPRC CSF1R CSF1R LOC103070587 LOC103070587 SYK SYK TNFSF18 TNFSF18 SRC SRC SEMA4D SEMA4D PTPN1 PTPN1 LRRK1 LRRK1 ERCC6 ERCC6 RIPK2 RIPK2 CD44 CD44 CD40 CD40 PIBF1 PIBF1 TNFRSF18 TNFRSF18 CD80 CD80 CD74 CD74 AGT AGT HCLS1 HCLS1 GATA1 GATA1 PARP9 PARP9 FYN FYN CLCF1 CLCF1 ABL1 ABL1 GHRL GHRL UNC119 UNC119 ENPP2 ENPP2 PLCG2 PLCG2 IGF1 IGF1 LOC103090474 LOC103090474 RIPK1 RIPK1 VTN VTN EFNA5 EFNA5 TGFA TGFA CTF1 CTF1 MLST8 MLST8 FGF7 FGF7 IL12A IL12A LRP4 LRP4 LOC103084127 LOC103084127 LOC103088461 LOC103088461 PDGFB PDGFB WNT3A WNT3A CNTF CNTF ARHGEF2 ARHGEF2 IL6R IL6R HAX1 HAX1 ITGB3 ITGB3 PECAM1 PECAM1 TREM2 TREM2 KIT KIT HES1 HES1 DOK7 DOK7 EFNA1 EFNA1 SH2D1B SH2D1B DVL2 DVL2 LOC103071311 LOC103071311 VEGFA VEGFA CRLF1 CRLF1 HPX HPX NOD2 NOD2 FGF10 FGF10 GRM5 GRM5 LIF LIF OSM OSM GREM1 GREM1 LTK LTK IL34 IL34 AREG AREG EREG EREG IL3 IL3 IFNG IFNG CSF2 CSF2 IL5 IL5 EGFR EGFR NOX4 NOX4 PRNP PRNP IL15 IL15 FAM150A FAM150A CASS4 CASS4 MTOR MTOR BTC BTC EPGN EPGN PPAP2B PPAP2B BANK1 BANK1 TAL1 TAL1 SRCIN1 SRCIN1 LYN LYN EGF EGF CSF3 CSF3 NEDD9 NEDD9 PAK2 PAK2 GAS6 GAS6 BMP6 BMP6 PTK2B PTK2B HTR2A HTR2A ANGPT4 ANGPT4 IL12B IL12B NRG1 NRG1 RICTOR RICTOR EPHA4 EPHA4 FGFR3 FGFR3 DGKQ DGKQ IGF2 IGF2 CD81 CD81 ADRA1A ADRA1A FBXW7 FBXW7 HGF HGF ERBB3 ERBB3 ITGA5 ITGA5 RELN RELN FAM150B FAM150B EPO EPO IL11 IL11 TNFRSF1A TNFRSF1A GFRA1 GFRA1 IL23A IL23A CSPG4 CSPG4 ERBB4 ERBB4 FBXW9 FBXW9 NEURL1 NEURL1 ARL2BP ARL2BP NCF1 NCF1 ADRA2A ADRA2A PTPN11 PTPN11 IL6ST IL6ST LRP8 LRP8 ABI1 ABI1 AFAP1L2 AFAP1L2 ALK ALK FGF8 FGF8 ISL1 ISL1 NRP1 NRP1 IL19 IL19 THBS4 THBS4 IL31RA IL31RA STAP1 STAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HBEGFProheparin-binding EGF-like growth factor. (208 aa)
LOC103069874Abl interactor 1-like. (235 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1121 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (456 aa)
LOC103070587Tyrosine-protein kinase ABL1-like. (126 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
TNFSF18Tumor necrosis factor ligand superfamily member 18. (178 aa)
SRCTyrosine-protein kinase. (548 aa)
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
LRRK1Leucine-rich repeat serine/threonine-protein kinase 1. (2015 aa)
ERCC6DNA excision repair protein ERCC-6. (1485 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (538 aa)
CD44CD44 antigen isoform X1. (745 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
PIBF1Progesterone-induced-blocking factor 1. (749 aa)
TNFRSF18Tumor necrosis factor receptor superfamily member 18 isoform X1. (233 aa)
CD80T-lymphocyte activation antigen CD80 isoform X1. (234 aa)
CD74HLA class II histocompatibility antigen gamma chain. (278 aa)
AGTAngiotensinogen; Belongs to the serpin family. (477 aa)
HCLS1Hematopoietic lineage cell-specific protein isoform X1. (479 aa)
GATA1Erythroid transcription factor. (413 aa)
PARP9Poly [ADP-ribose] polymerase 9. (814 aa)
FYNTyrosine-protein kinase. (537 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
ABL1Tyrosine-protein kinase. (1006 aa)
GHRLAppetite-regulating hormone isoform X1. (141 aa)
UNC119Protein unc-119 homolog A. (241 aa)
ENPP2Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 isoform X1. (936 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1266 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
LOC103090474LOW QUALITY PROTEIN: cardiotrophin-2-like. (253 aa)
RIPK1Receptor-interacting serine/threonine-protein kinase 1. (523 aa)
VTNVitronectin isoform X1. (565 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (228 aa)
TGFAProtransforming growth factor alpha. (145 aa)
CTF1Cardiotrophin-1. (185 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
FGF7Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (257 aa)
LRP4Low-density lipoprotein receptor-related protein 4. (1881 aa)
LOC103084127Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
LOC103088461Actin filament-associated protein 1-like 2-like. (190 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
CNTFCiliary neurotrophic factor. (200 aa)
ARHGEF2Rho guanine nucleotide exchange factor 2 isoform X1. (987 aa)
IL6RInterleukin-6 receptor subunit alpha. (499 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (285 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
PECAM1Platelet endothelial cell adhesion molecule. (779 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
HES1Transcription factor HES-1. (280 aa)
DOK7Protein Dok-7 isoform X1. (494 aa)
EFNA1ephrin-A1; Belongs to the ephrin family. (242 aa)
SH2D1BLOW QUALITY PROTEIN: SH2 domain-containing protein 1B. (133 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
LOC103071311ADP-ribosylation factor-like protein 2-binding protein-like. (125 aa)
VEGFAVascular endothelial growth factor A isoform X1; Belongs to the PDGF/VEGF growth factor family. (214 aa)
CRLF1Cytokine receptor-like factor 1. (616 aa)
HPXHemopexin; Binds heme and transports it to the liver for breakdown and iron recovery, after which the free hemopexin returns to the circulation. (455 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
GRM5Metabotropic glutamate receptor 5 isoform X1. (1204 aa)
LIFLeukemia inhibitory factor. (202 aa)
OSMoncostatin-M. (246 aa)
GREM1Gremlin. (184 aa)
LTKLOW QUALITY PROTEIN: leukocyte tyrosine kinase receptor. (858 aa)
IL34LOW QUALITY PROTEIN: interleukin-34. (268 aa)
AREGAmphiregulin isoform X1. (254 aa)
EREGProepiregulin. (163 aa)
IL3Interleukin-3. (144 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
CSF2Granulocyte-macrophage colony-stimulating factor. (144 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
PRNPMajor prion protein; Belongs to the prion family. (257 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
FAM150AProtein FAM150A. (131 aa)
CASS4Cas scaffolding protein family member 4. (801 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
BTCProbetacellulin. (178 aa)
EPGNEpigen isoform X1. (153 aa)
PPAP2BLipid phosphate phosphohydrolase 3. (312 aa)
BANK1B-cell scaffold protein with ankyrin repeats. (751 aa)
TAL1T-cell acute lymphocytic leukemia protein 1. (318 aa)
SRCIN1SRC kinase signaling inhibitor 1. (1165 aa)
LYNTyrosine-protein kinase. (516 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
CSF3Granulocyte colony-stimulating factor. (195 aa)
NEDD9Enhancer of filamentation 1-like. (819 aa)
PAK2Non-specific serine/threonine protein kinase. (523 aa)
GAS6Growth arrest-specific protein 6. (540 aa)
BMP6Bone morphogenetic protein 6. (495 aa)
PTK2BProtein-tyrosine kinase 2-beta isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1009 aa)
HTR2A5-hydroxytryptamine receptor 2A. (469 aa)
ANGPT4Angiopoietin-4. (498 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
NRG1Pro-neuregulin-3, membrane-bound isoform-like isoform X1. (641 aa)
RICTORRapamycin-insensitive companion of mTOR-like isoform X1. (1580 aa)
EPHA4Ephrin type-A receptor 4-like isoform X1. (986 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
DGKQDiacylglycerol kinase. (937 aa)
IGF2Insulin-like growth factor II isoform X1. (237 aa)
CD81Tetraspanin. (201 aa)
ADRA1Aalpha-1A adrenergic receptor. (467 aa)
FBXW7F-box/WD repeat-containing protein 7 isoform X1. (707 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (729 aa)
ERBB3Receptor tyrosine-protein kinase erbB-3. (1338 aa)
ITGA5Integrin alpha-5; Belongs to the integrin alpha chain family. (1053 aa)
RELNReelin isoform X1. (3460 aa)
FAM150BProtein FAM150B. (152 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
IL11Interleukin-11 isoform X1. (199 aa)
TNFRSF1ATumor necrosis factor receptor superfamily member 1A. (445 aa)
GFRA1GDNF family receptor alpha; Belongs to the GDNFR family. (468 aa)
IL23AInterleukin-23 subunit alpha. (187 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2315 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
FBXW9F-box/WD repeat-containing protein 9. (458 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1. (574 aa)
ARL2BPADP-ribosylation factor-like protein 2-binding protein. (163 aa)
NCF1Neutrophil cytosol factor 1. (393 aa)
ADRA2Aalpha-2A adrenergic receptor. (462 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
LRP8LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 8. (958 aa)
ABI1Abl interactor 1-like isoform X1. (379 aa)
AFAP1L2Actin filament-associated protein 1-like 2. (655 aa)
ALKTyrosine-protein kinase receptor. (1619 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
ISL1Insulin gene enhancer protein ISL-1. (349 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (924 aa)
IL19Interleukin-19. (177 aa)
THBS4Thrombospondin-4. (961 aa)
IL31RALOW QUALITY PROTEIN: interleukin 31 receptor A. (268 aa)
STAP1LOW QUALITY PROTEIN: signal transducing adaptor family member 1. (231 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
Server load: low (40%) [HD]