STRINGSTRING
SEMA4D SEMA4D NIN NIN SEMA7A SEMA7A LOC103086580 LOC103086580 CAMK2B CAMK2B IL1B IL1B KRAS KRAS OLIG2 OLIG2 NPTN NPTN ISLR2 ISLR2 OBSL1 OBSL1 PLXNB1 PLXNB1 AMIGO3 AMIGO3 ISLR ISLR EGR2 EGR2 NR2E1 NR2E1 TGM2 TGM2 TRIM32 TRIM32 MAP2K1 MAP2K1 RNF112 RNF112 VEGFC VEGFC AMIGO1 AMIGO1 LOC103071987 LOC103071987 LRP2 LRP2 ACY3 ACY3 CLCF1 CLCF1 TIAM2 TIAM2 WNT2 WNT2 ZNF335 ZNF335 BHLHB9 BHLHB9 MAP3K13 MAP3K13 PLXNA2 PLXNA2 PAFAH1B1 PAFAH1B1 ASCL1 ASCL1 SOX10 SOX10 CAPRIN2 CAPRIN2 DRD2 DRD2 LOC103070818 LOC103070818 NKX2-2 NKX2-2 EFNA5 EFNA5 SOX8 SOX8 METRN METRN LOC103088094 LOC103088094 TENM4 TENM4 SERPINF1 SERPINF1 PLXNB2 PLXNB2 DCT DCT ASPA ASPA ZFYVE27 ZFYVE27 SHANK3 SHANK3 WNT3A WNT3A PLXNB3 PLXNB3 ROBO1 ROBO1 NGF NGF SHH SHH MAP6 MAP6 PLXNA4 PLXNA4 CRABP2 CRABP2 FBXW8 FBXW8 CUL7 CUL7 METRNL METRNL KHDC3L KHDC3L SRF SRF GSX2 GSX2 OPRM1 OPRM1 NEFL NEFL FN1 FN1 HES1 HES1 MECP2 MECP2 LOC103079308 LOC103079308 LPAR3 LPAR3 PLXNA3 PLXNA3 NUMB NUMB SNW1 SNW1 MEGF8 MEGF8 NTN1 NTN1 NUMBL NUMBL PAX6 PAX6 DMRTA2 DMRTA2 TGFB1 TGFB1 BIN1 BIN1 EPHB2 EPHB2 CDKL3 CDKL3 NOTCH1 NOTCH1 SERPINE2 SERPINE2 KDM1A KDM1A SPEN SPEN LIF LIF STK11 STK11 PLXND1 PLXND1 IST1 IST1 IL34 IL34 LOC103073422 LOC103073422 CDH4 CDH4 IFNG IFNG JADE2 JADE2 GOLGA4 GOLGA4 LOC103086949 LOC103086949 PLAG1 PLAG1 DBN1 DBN1 MTOR MTOR SS18L1 SS18L1 MAN2A1 MAN2A1 LAYN LAYN LIG4 LIG4 CUX2 CUX2 TRPV2 TRPV2 XRCC5 XRCC5 HAP1 HAP1 TNFRSF1B TNFRSF1B LOC103073063 LOC103073063 DBNL DBNL FZD3 FZD3 FAIM FAIM PKHD1L1 PKHD1L1 CTNNB1 CTNNB1 PRKCI PRKCI PTN PTN CHODL CHODL GPER1 GPER1 UFL1 UFL1 PLXNA1 PLXNA1 WNT3 WNT3 CDKL5 CDKL5 ELL3 ELL3 CX3CR1 CX3CR1 LIMK1 LIMK1 BRAF BRAF SRRT SRRT DISC1 DISC1 HDAC1 HDAC1 BMPR2 BMPR2 LOC103087254 LOC103087254 RELN RELN GLI3 GLI3 PLXNC1 PLXNC1 CAPRIN1 CAPRIN1 NEURL1 NEURL1 FGF2 FGF2 BMP2 BMP2 XRCC2 XRCC2 IL6ST IL6ST DSCAM DSCAM LRP8 LRP8 STK25 STK25 NKX6-1 NKX6-1 LOC103082929 LOC103082929 SMARCD3 SMARCD3 KIAA1598 KIAA1598 SMO SMO RASSF10 RASSF10 ANKRD27 ANKRD27 POU4F2 POU4F2 HIF1A HIF1A LOC103078457 LOC103078457 ITGB1 ITGB1 DHX36 DHX36 LOC103082663 LOC103082663 PRKCH PRKCH LOC103086063 LOC103086063 ZNF488 ZNF488
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA4Dsemaphorin-4D; Belongs to the semaphorin family. (863 aa)
NINNinein isoform X1. (2137 aa)
SEMA7Asemaphorin-7A isoform X1; Belongs to the semaphorin family. (663 aa)
LOC103086580Protein ZNF365-like. (408 aa)
CAMK2BCalcium/calmodulin-dependent protein kinase type II subunit beta isoform X1. (542 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
KRASGTPase KRas. (188 aa)
OLIG2Oligodendrocyte transcription factor 2. (270 aa)
NPTNNeuroplastin isoform X1. (398 aa)
ISLR2Immunoglobulin superfamily containing leucine-rich repeat protein 2. (746 aa)
OBSL1Obscurin-like protein 1 isoform X1. (1901 aa)
PLXNB1plexin-B1 isoform X1. (2135 aa)
AMIGO3Amphoterin-induced protein 3. (510 aa)
ISLRImmunoglobulin superfamily containing leucine-rich repeat protein. (429 aa)
EGR2E3 SUMO-protein ligase EGR2 isoform X1. (485 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
TGM2Protein-glutamine gamma-glutamyltransferase 2 isoform X1. (687 aa)
TRIM32E3 ubiquitin-protein ligase TRIM32 isoform X1. (653 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
RNF112RING finger protein 112. (629 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (420 aa)
AMIGO1Amphoterin-induced protein 1 isoform X1. (493 aa)
LOC103071987Oncomodulin-like; Belongs to the parvalbumin family. (109 aa)
LRP2Low-density lipoprotein receptor-related protein 2. (4672 aa)
ACY3LOW QUALITY PROTEIN: N-acyl-aromatic-L-amino acid amidohydrolase (Carboxylate-forming). (200 aa)
CLCF1Cardiotrophin-like cytokine factor 1. (215 aa)
TIAM2T-lymphoma invasion and metastasis-inducing protein 2 isoform X1. (1680 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
ZNF335Zinc finger protein 335. (1354 aa)
BHLHB9Protein BHLHb9. (566 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (968 aa)
PLXNA2plexin-A2. (1894 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
ASCL1Achaete-scute homolog 1. (227 aa)
SOX10Transcription factor SOX-10 isoform X1. (468 aa)
CAPRIN2Caprin-2 isoform X1. (1070 aa)
DRD2D(2) dopamine receptor isoform X2; Belongs to the G-protein coupled receptor 1 family. (443 aa)
LOC103070818Homeobox protein Nkx-6.1-like. (448 aa)
NKX2-2Homeobox protein Nkx-2.2. (273 aa)
EFNA5ephrin-A5; Belongs to the ephrin family. (228 aa)
SOX8Transcription factor SOX-8. (463 aa)
METRNMeteorin. (291 aa)
LOC103088094Down syndrome cell adhesion molecule-like. (991 aa)
TENM4Teneurin-4-like. (2768 aa)
SERPINF1Pigment epithelium-derived factor isoform X1; Belongs to the serpin family. (437 aa)
PLXNB2plexin-B2. (1847 aa)
DCTL-dopachrome tautomerase isoform X1. (519 aa)
ASPAAspartoacylase. (313 aa)
ZFYVE27Protrudin isoform X1. (418 aa)
SHANK3SH3 and multiple ankyrin repeat domains protein 3. (1586 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
PLXNB3plexin-B3. (1906 aa)
ROBO1Roundabout homolog 1-like isoform X1. (1652 aa)
NGFBeta-nerve growth factor; Belongs to the NGF-beta family. (241 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (454 aa)
MAP6Microtubule-associated protein 6. (767 aa)
PLXNA4plexin-A4 isoform X3. (1903 aa)
CRABP2Cellular retinoic acid-binding protein 2; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (138 aa)
FBXW8F-box/WD repeat-containing protein 8 isoform X1. (599 aa)
CUL7Cullin-7 isoform X1; Belongs to the cullin family. (1726 aa)
METRNLMeteorin-like protein. (309 aa)
KHDC3LKHDC3-like protein. (237 aa)
SRFSerum response factor. (510 aa)
GSX2GS homeobox 2. (413 aa)
OPRM1Mu-type opioid receptor isoform X1; Belongs to the G-protein coupled receptor 1 family. (479 aa)
NEFLNeurofilament light polypeptide; Belongs to the intermediate filament family. (552 aa)
FN1LOW QUALITY PROTEIN: fibronectin. (2483 aa)
HES1Transcription factor HES-1. (280 aa)
MECP2methyl-CpG-binding protein 2. (537 aa)
LOC103079308Uncharacterized protein LOC103079308. (289 aa)
LPAR3Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (355 aa)
PLXNA3plexin-A3. (1873 aa)
NUMBProtein numb homolog isoform X1. (653 aa)
SNW1SNW domain-containing protein 1 isoform X1. (536 aa)
MEGF8Multiple epidermal growth factor-like domains protein 8. (2778 aa)
NTN1Netrin-1 isoform X1. (604 aa)
NUMBLNumb-like protein. (590 aa)
PAX6Paired box protein Pax-6 isoform X1. (436 aa)
DMRTA2Doublesex- and mab-3-related transcription factor A2. (534 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
BIN1Myc box-dependent-interacting protein 1 isoform X1. (594 aa)
EPHB2Ephrin type-B receptor 2 isoform X1. (964 aa)
CDKL3LOW QUALITY PROTEIN: cyclin-dependent kinase-like 3. (584 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
SERPINE2Glia-derived nexin isoform X2; Belongs to the serpin family. (398 aa)
KDM1ALysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (877 aa)
SPENMsx2-interacting protein. (3635 aa)
LIFLeukemia inhibitory factor. (202 aa)
STK11Serine/threonine-protein kinase STK11; Belongs to the protein kinase superfamily. (438 aa)
PLXND1plexin-D1. (1747 aa)
IST1IST1 homolog isoform X1. (364 aa)
IL34LOW QUALITY PROTEIN: interleukin-34. (268 aa)
LOC103073422LOW QUALITY PROTEIN: short stature homeobox protein 2-like. (359 aa)
CDH4Cadherin-4; Cadherins are calcium-dependent cell adhesion proteins. (901 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
JADE2Protein Jade-2 isoform X1. (849 aa)
GOLGA4Golgin subfamily A member 4 isoform X1. (2244 aa)
LOC103086949Chondrolectin-like isoform X3. (232 aa)
PLAG1Zinc finger protein PLAG1 isoform X1. (499 aa)
DBN1Drebrin. (648 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2544 aa)
SS18L1Calcium-responsive transactivator. (402 aa)
MAN2A1Alpha-mannosidase. (1145 aa)
LAYNLayilin. (373 aa)
LIG4DNA ligase. (911 aa)
CUX2Homeobox protein cut-like. (1507 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (761 aa)
XRCC5X-ray repair cross-complementing protein 5. (733 aa)
HAP1LOW QUALITY PROTEIN: huntingtin-associated protein 1. (550 aa)
TNFRSF1BTumor necrosis factor receptor superfamily member 1B isoform X1. (453 aa)
LOC103073063Forkhead box protein G1-like isoform X1. (483 aa)
DBNLDrebrin-like protein isoform X1. (438 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
FAIMFas apoptotic inhibitory molecule 1. (247 aa)
PKHD1L1fibrocystin-L. (4224 aa)
CTNNB1Catenin beta-1 isoform X1. (781 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (597 aa)
PTNPleiotrophin isoform X1. (181 aa)
CHODLChondrolectin-like isoform X2. (273 aa)
GPER1G-protein coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
UFL1E3 UFM1-protein ligase 1. (796 aa)
PLXNA1plexin-A1. (1890 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
CDKL5Cyclin-dependent kinase-like 5. (960 aa)
ELL3RNA polymerase II elongation factor ELL3 isoform X2. (401 aa)
CX3CR1CX3C chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
LIMK1LIM domain kinase 1. (647 aa)
BRAFSerine/threonine-protein kinase B-raf. (763 aa)
SRRTSerrate RNA effector molecule homolog isoform X2. (876 aa)
DISC1Disrupted in schizophrenia 1 protein. (856 aa)
HDAC1Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (538 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LOC103087254SLIT and NTRK-like protein 1-like. (696 aa)
RELNReelin isoform X1. (3460 aa)
GLI3Transcriptional activator GLI3. (1590 aa)
PLXNC1LOW QUALITY PROTEIN: plexin-C1. (1572 aa)
CAPRIN1Caprin-1. (707 aa)
NEURL1E3 ubiquitin-protein ligase NEURL1. (574 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
XRCC2DNA repair protein XRCC2-like. (280 aa)
IL6STInterleukin-6 receptor subunit beta isoform X1. (918 aa)
DSCAMDown syndrome cell adhesion molecule-like. (1226 aa)
LRP8LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 8. (958 aa)
STK25Serine/threonine-protein kinase 25 isoform X1. (426 aa)
NKX6-1Homeobox protein Nkx-6.1-like. (365 aa)
LOC103082929Protein kinase C eta type-like. (165 aa)
SMARCD3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3. (483 aa)
KIAA1598Shootin-1 isoform X1. (571 aa)
SMOSmoothened homolog; Belongs to the G-protein coupled receptor Fz/Smo family. (782 aa)
RASSF10Ras association domain-containing protein 10. (501 aa)
ANKRD27Ankyrin repeat domain-containing protein 27. (1071 aa)
POU4F2POU domain protein. (408 aa)
HIF1AHypoxia-inducible factor 1-alpha isoform X2. (822 aa)
LOC103078457Homeobox protein orthopedia-like. (331 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (805 aa)
DHX36Probable ATP-dependent RNA helicase DHX36 isoform X1. (1014 aa)
LOC103082663Protein kinase C epsilon type-like. (248 aa)
PRKCHProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (522 aa)
LOC103086063Homeobox protein orthopedia-like. (267 aa)
ZNF488LOW QUALITY PROTEIN: zinc finger protein 488. (324 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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