STRINGSTRING
MAP2K2 MAP2K2 LOC103080512 LOC103080512 MAP4K2 MAP4K2 SPDYC SPDYC SLC27A1 SLC27A1 HTR2B HTR2B PAK1 PAK1 IL34 IL34 PIH1D1 PIH1D1 IFNG IFNG FZD5 FZD5 PPP2CA PPP2CA EGFR EGFR NOX4 NOX4 MAP3K11 MAP3K11 PDGFC PDGFC INCENP INCENP EPGN EPGN BMPR1B BMPR1B RPTOR RPTOR CCNYL1 CCNYL1 CAB39 CAB39 ERBB2 ERBB2 EGF EGF PSMD10 PSMD10 ETAA1 ETAA1 MST1R MST1R SPRY2 SPRY2 DRD4 DRD4 LOC103088508 LOC103088508 PDGFA PDGFA FGF18 FGF18 RICTOR RICTOR EPHA4 EPHA4 ARHGEF5 ARHGEF5 CCND1 CCND1 HRAS HRAS IGF2 IGF2 DAB2IP DAB2IP CAB39L CAB39L FGF1 FGF1 ADIPOQ ADIPOQ RHOA RHOA PDCD10 PDCD10 IL1B IL1B LRRK2 LRRK2 PTPRC PTPRC HMGA2 HMGA2 CSF1R CSF1R CKS2 CKS2 SYK SYK SRC SRC FERMT2 FERMT2 TPD52L1 TPD52L1 TCL1B TCL1B PTPN1 PTPN1 CDK5R2 CDK5R2 EDN1 EDN1 ADRB2 ADRB2 NTRK3 NTRK3 FZD4 FZD4 ATP2B4 ATP2B4 CD40 CD40 RAPGEF2 RAPGEF2 TCL1A TCL1A LOC103080337 LOC103080337 DBF4 DBF4 AJUBA AJUBA P2RX7 P2RX7 LOC103081641 LOC103081641 MAP2K1 MAP2K1 PARP16 PARP16 ERN2 ERN2 PROX1 PROX1 CAMK1 CAMK1 CDK5R1 CDK5R1 PDGFD PDGFD PKD2 PKD2 LOC103088795 LOC103088795 SASH1 SASH1 ADAM8 ADAM8 MAP3K13 MAP3K13 TELO2 TELO2 IGF1 IGF1 TAB1 TAB1 MAP3K7 MAP3K7 CD40LG CD40LG DAZAP2 DAZAP2 CCNT1 CCNT1 TGFA TGFA SYAP1 SYAP1 MLST8 MLST8 FAM20A FAM20A PIK3CG PIK3CG CCNK CCNK AXIN1 AXIN1 LOC103085242 LOC103085242 PKD1 PKD1 TAOK3 TAOK3 PDGFB PDGFB NEK10 NEK10 ROBO1 ROBO1 RPS3 RPS3 PIK3R6 PIK3R6 LOC103091479 LOC103091479 STRADA STRADA ERN1 ERN1 BMPR1A BMPR1A WNT5A WNT5A SLC8A2 SLC8A2 KIT KIT DDX3X DDX3X SIRT1 SIRT1 IRAK1 IRAK1 MAP3K4 MAP3K4 AGER AGER TNFRSF11A TNFRSF11A DVL2 DVL2 LOC103088826 LOC103088826 PIK3R5 PIK3R5 RASGRP1 RASGRP1 CKS1B CKS1B INSR INSR CCND3 CCND3 MAP3K10 MAP3K10 TGFB1 TGFB1 PSEN1 PSEN1 TRAF2 TRAF2 THBS1 THBS1 NOD2 NOD2 BMPR2 BMPR2 LOC103069433 LOC103069433 FGD2 FGD2 MTCP1 MTCP1 STRADB STRADB EZH2 EZH2 CCND2 CCND2 LOC103069061 LOC103069061 RALB RALB LTF LTF ADAM9 ADAM9 TNFSF11 TNFSF11 ALS2 ALS2 FGF2 FGF2 DVL3 DVL3 ADRA2A ADRA2A LOC103077888 LOC103077888 BMP2 BMP2 FGFR1 FGFR1 IQGAP1 IQGAP1 SPDYA SPDYA FZD10 FZD10 MAPRE3 MAPRE3 LOC103072107 LOC103072107 CEMIP CEMIP CIB1 CIB1 CCL19 CCL19 MNAT1 MNAT1 CCNT2 CCNT2 DBF4B DBF4B CCNY CCNY FLT1 FLT1 LOC103070824 LOC103070824 PSRC1 PSRC1 ACSL1 ACSL1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAP2K2Dual specificity mitogen-activated protein kinase kinase 2; Belongs to the protein kinase superfamily. (400 aa)
LOC103080512FYVE, RhoGEF and PH domain-containing protein 2-like. (213 aa)
MAP4K2Non-specific serine/threonine protein kinase; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (842 aa)
SPDYCSpeedy protein C. (299 aa)
SLC27A1Long-chain fatty acid transport protein 1. (646 aa)
HTR2B5-hydroxytryptamine receptor 2B. (537 aa)
PAK1Non-specific serine/threonine protein kinase. (563 aa)
IL34LOW QUALITY PROTEIN: interleukin-34. (268 aa)
PIH1D1PIH1 domain-containing protein 1 isoform X1. (315 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
FZD5Frizzled-5; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
EGFRReceptor protein-tyrosine kinase. (1209 aa)
NOX4NADPH oxidase 4 isoform X1. (578 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (858 aa)
PDGFCPlatelet-derived growth factor C. (345 aa)
INCENPInner centromere protein. (945 aa)
EPGNEpigen isoform X1. (153 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (543 aa)
RPTORRegulatory-associated protein of mTOR isoform X1. (1335 aa)
CCNYL1cyclin-Y-like protein 1 isoform X1; Belongs to the cyclin family. (363 aa)
CAB39Calcium-binding protein 39. (373 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
EGFPro-epidermal growth factor; EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. (1205 aa)
PSMD1026S proteasome non-ATPase regulatory subunit 10 isoform X1. (226 aa)
ETAA1Ewing's tumor-associated antigen 1 homolog. (905 aa)
MST1RMacrophage-stimulating protein receptor. (1382 aa)
SPRY2Protein sprouty homolog 2 isoform X1. (315 aa)
DRD4LOW QUALITY PROTEIN: D(4) dopamine receptor; Belongs to the G-protein coupled receptor 1 family. (390 aa)
LOC103088508TNF receptor-associated factor 6-like. (251 aa)
PDGFAPlatelet-derived growth factor subunit A; Belongs to the PDGF/VEGF growth factor family. (211 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
RICTORRapamycin-insensitive companion of mTOR-like isoform X1. (1580 aa)
EPHA4Ephrin type-A receptor 4-like isoform X1. (986 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1576 aa)
CCND1G1/S-specific cyclin-D1; Belongs to the cyclin family. (295 aa)
HRASGTPase HRas isoform X1. (189 aa)
IGF2Insulin-like growth factor II isoform X1. (237 aa)
DAB2IPLOW QUALITY PROTEIN: disabled homolog 2-interacting protein. (1173 aa)
CAB39LCalcium-binding protein 39-like isoform X1. (337 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (189 aa)
ADIPOQC1Q and collagen domain containing adiponectin. (242 aa)
RHOATransforming protein RhoA isoform X1. (221 aa)
PDCD10Programmed cell death protein 10 isoform X1. (212 aa)
IL1BMultifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa)
LRRK2Leucine-rich repeat serine/threonine-protein kinase 2-like. (920 aa)
PTPRCReceptor-type tyrosine-protein phosphatase C. (1121 aa)
HMGA2High mobility group protein HMGI-C. (109 aa)
CSF1RMacrophage colony-stimulating factor 1 receptor-like; Belongs to the protein kinase superfamily. Tyr protein kinase family. (456 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
SYKTyrosine-protein kinase SYK isoform X1. (636 aa)
SRCTyrosine-protein kinase. (548 aa)
FERMT2Fermitin family homolog 2 isoform X1. (687 aa)
TPD52L1LOW QUALITY PROTEIN: tumor protein D53. (269 aa)
TCL1BT-cell leukemia/lymphoma protein 1B. (128 aa)
PTPN1Tyrosine-protein phosphatase non-receptor type. (440 aa)
CDK5R2Cyclin-dependent kinase 5 activator. (369 aa)
EDN1Endothelin-1. (202 aa)
ADRB2Beta-2 adrenergic receptor. (419 aa)
NTRK3Tyrosine-protein kinase receptor. (839 aa)
FZD4Frizzled-4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1207 aa)
CD40Tumor necrosis factor receptor superfamily member 5. (280 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1483 aa)
TCL1AT-cell leukemia/lymphoma protein 1A. (115 aa)
LOC103080337Deleted in autism protein 1. (430 aa)
DBF4Protein DBF4 homolog A isoform X1. (680 aa)
AJUBALIM domain-containing protein ajuba. (557 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (594 aa)
LOC103081641LOW QUALITY PROTEIN: dual specificity mitogen-activated protein kinase kinase 6-like; Belongs to the protein kinase superfamily. (394 aa)
MAP2K1Dual specificity mitogen-activated protein kinase kinase 1 isoform X1; Belongs to the protein kinase superfamily. (393 aa)
PARP16Poly [ADP-ribose] polymerase. (322 aa)
ERN2Serine/threonine-protein kinase/endoribonuclease IRE2. (924 aa)
PROX1Prospero homeobox protein 1. (737 aa)
CAMK1Calcium/calmodulin-dependent protein kinase type 1; Belongs to the protein kinase superfamily. (370 aa)
CDK5R1Cyclin-dependent kinase 5 activator. (307 aa)
PDGFDPlatelet-derived growth factor D-like isoform X1. (370 aa)
PKD2LOW QUALITY PROTEIN: polycystin-2. (963 aa)
LOC103088795TNF receptor-associated factor 6-like. (315 aa)
SASH1SAM and SH3 domain-containing protein 1. (1235 aa)
ADAM8Disintegrin and metalloproteinase domain-containing protein 8. (1009 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (968 aa)
TELO2Telomere length regulation protein TEL2 homolog. (825 aa)
IGF1Insulin-like growth factor I isoform X1. (174 aa)
TAB1TGF-beta-activated kinase 1 and MAP3K7-binding protein 1. (504 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (606 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
DAZAP2DAZ-associated protein 2 isoform X1. (207 aa)
CCNT1cyclin-T1; Belongs to the cyclin family. (727 aa)
TGFAProtransforming growth factor alpha. (145 aa)
SYAP1Synapse-associated protein 1 isoform X1. (358 aa)
MLST8Target of rapamycin complex subunit LST8 isoform X1. (326 aa)
FAM20AProtein FAM20A. (521 aa)
PIK3CGLOW QUALITY PROTEIN: phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform; Belongs to the PI3/PI4-kinase family. (1126 aa)
CCNKcyclin-K; Belongs to the cyclin family. (524 aa)
AXIN1Axin-1. (866 aa)
LOC103085242Glycine N-acyltransferase-like. (295 aa)
PKD1Polycystin-1. (4305 aa)
TAOK3Serine/threonine-protein kinase TAO3 isoform X1. (898 aa)
PDGFBPlatelet-derived growth factor subunit B isoform X1; Belongs to the PDGF/VEGF growth factor family. (241 aa)
NEK10Serine/threonine-protein kinase Nek10. (1173 aa)
ROBO1Roundabout homolog 1-like isoform X1. (1652 aa)
RPS340S ribosomal protein S3 isoform X3; Belongs to the universal ribosomal protein uS3 family. (254 aa)
PIK3R6Phosphoinositide 3-kinase regulatory subunit 6. (756 aa)
LOC103091479Uncharacterized protein C8orf4 homolog. (106 aa)
STRADASTE20-related kinase adapter protein alpha isoform X1. (431 aa)
ERN1LOW QUALITY PROTEIN: serine/threonine-protein kinase/endoribonuclease IRE1. (1251 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
SLC8A2Sodium/calcium exchanger 2; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (922 aa)
KITMast/stem cell growth factor receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (977 aa)
DDX3XATP-dependent RNA helicase DDX3X-like isoform X1; Belongs to the DEAD box helicase family. (662 aa)
SIRT1LOW QUALITY PROTEIN: NAD-dependent protein deacetylase sirtuin-1. (695 aa)
IRAK1Interleukin-1 receptor-associated kinase 1. (732 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1644 aa)
AGERAdvanced glycosylation end product-specific receptor isoform X1. (421 aa)
TNFRSF11ATumor necrosis factor receptor superfamily member 11A. (850 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2. (734 aa)
LOC103088826Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (143 aa)
PIK3R5Phosphoinositide 3-kinase regulatory subunit 5. (873 aa)
RASGRP1RAS guanyl-releasing protein 1 isoform X1. (797 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
CCND3G1/S-specific cyclin-D3 isoform X1; Belongs to the cyclin family. (358 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (948 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
PSEN1Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (468 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
THBS1Thrombospondin-1. (1170 aa)
NOD2Nucleotide-binding oligomerization domain-containing protein 2. (1013 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1038 aa)
LOC103069433Alsin-like. (1113 aa)
FGD2FYVE, RhoGEF and PH domain-containing protein 2. (551 aa)
MTCP1Protein p13 MTCP-1. (107 aa)
STRADBSTE20-related kinase adapter protein beta isoform X1. (418 aa)
EZH2Histone-lysine N-methyltransferase EZH2 isoform X1. (751 aa)
CCND2G1/S-specific cyclin-D2; Belongs to the cyclin family. (289 aa)
LOC103069061Mitogen-activated protein kinase kinase kinase 5-like. (127 aa)
RALBRas-related protein Ral-B. (206 aa)
LTFLactotransferrin isoform X2; Belongs to the transferrin family. (730 aa)
ADAM9Disintegrin and metalloproteinase domain-containing protein 9. (819 aa)
TNFSF11Tumor necrosis factor ligand superfamily member 11; Belongs to the tumor necrosis factor family. (322 aa)
ALS2Alsin-like. (527 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (373 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
ADRA2Aalpha-2A adrenergic receptor. (462 aa)
LOC103077888Uncharacterized protein LOC103077888. (412 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
FGFR1Fibroblast growth factor receptor. (837 aa)
IQGAP1Ras GTPase-activating-like protein IQGAP1. (1627 aa)
SPDYASpeedy protein A. (312 aa)
FZD10LOW QUALITY PROTEIN: frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
MAPRE3Microtubule-associated protein RP/EB family member 3 isoform X1. (301 aa)
LOC10307210740S ribosomal protein S3-like; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CEMIPProtein KIAA1199 homolog. (1312 aa)
CIB1Calcium and integrin-binding protein 1. (191 aa)
CCL19C-C motif chemokine. (100 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
CCNT2LOW QUALITY PROTEIN: cyclin T2; Belongs to the cyclin family. (669 aa)
DBF4BLOW QUALITY PROTEIN: DBF4 zinc finger B. (780 aa)
CCNYcyclin-Y-like isoform X1; Belongs to the cyclin family. (311 aa)
FLT1Vascular endothelial growth factor receptor 1 isoform X1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1339 aa)
LOC103070824Leucine-rich repeat serine/threonine-protein kinase 2-like. (1609 aa)
PSRC1LOW QUALITY PROTEIN: proline/serine-rich coiled-coil 1. (310 aa)
ACSL1LOW QUALITY PROTEIN: acyl-CoA synthetase long-chain family member 1. (711 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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