STRINGSTRING
NOTCH2 NOTCH2 ACTA2 ACTA2 EDNRA EDNRA AQP1 AQP1 OSR1 OSR1 EGR1 EGR1 NOTCH1 NOTCH1 HES1 HES1 PECAM1 PECAM1 PDGFRA PDGFRA TCF21 TCF21 BMP4 BMP4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NOTCH2Neurogenic locus notch homolog protein 2-like. (2471 aa)
ACTA2Actin, aortic smooth muscle isoform X1. (377 aa)
EDNRAEndothelin-1 receptor isoform X2. (318 aa)
AQP1Aquaporin-1; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
OSR1Protein odd-skipped-related 1. (267 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (531 aa)
NOTCH1Neurogenic locus notch homolog protein 1. (2536 aa)
HES1Transcription factor HES-1. (280 aa)
PECAM1Platelet endothelial cell adhesion molecule. (779 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
TCF21LOW QUALITY PROTEIN: transcription factor 21. (179 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
Your Current Organism:
Lipotes vexillifer
NCBI taxonomy Id: 118797
Other names: L. vexillifer, Yangtze River dolphin, baiji
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